DEFINITION
Ammonium Bicarbonate 470 g
Glacial Acetic Acid 453 g
Strong Ammonia Solution A sufficient quantity
Purified Water, freshly boiled and cooled Sufficient to produce 1000 mL
Extemporaneous preparation
The following directions apply.
Dissolve the Ammonium Bicarbonate by adding gradually to the Glacial Acetic Acid diluted with 350 mL of Purified Water. Add Strong Ammonia Solution until 0.05 mL of the resulting solution diluted with 0.5 mL of water gives a full blue colour with 0.05 mL of bromothymol blue solution R3 and a full yellow colour with 0.05 mL of thymol blue solution; about 100 mL of Strong Ammonia Solution is required. Add sufficient Purified Water to produce 1000 mL.
Content of ammonium acetate, C2H7NO2
55.0 to 60.0% w/v.
TESTS
Acidity or alkalinity
pH of a 10% v/v solution, 7.0 to 8.0, Appendix V L.
Weight per mL
1.085 to 1.095 g, Appendix V G.
ASSAY
To 5 mL add 50 mL of water and 12 mL of formaldehyde solution previously neutralised to phenolphthalein solution R1 and titrate with 1M sodium hydroxide VS using phenolphthalein solution R1 as indicator. Each mL of 1M sodium hydroxide VS is equivalent to 77.08 mg of C2H7NO2.
STORAGE
Strong Ammonium Acetate Solution should be kept in lead-free glass containers.
LABELLING
When ammonium acetate solution or dilute ammonium acetate solution is prescribed or demanded, Strong Ammonium Acetate Solution diluted to eight times its volume with freshly boiled and cooled Purified Water, shall be dispensed or supplied.
