Silver Nitrate Cutaneous Solution
NOTE: This monograph has been developed to cover unlicensed formulations.
DEFINITION
Silver Nitrate Solution is a cutaneous solution. It contains Silver Nitrate in Purified Water.
The solution complies with the requirements stated under Liquids for Cutaneous Application and with the following requirements. Where appropriate, the solution also complies with the requirements stated under Unlicensed Medicines.
Content of silver nitrate, AgNO3
95.0 to 105.0% of the stated amount.
IDENTIFICATION
Yields the reactions characteristic of silver salts and of nitrates, Appendix VI.
TESTS
Acidity
pH, 4.5 to 6.0, Appendix V L.
Clarity and colour of solution
The solution is clear, Appendix IV A, and colourless, Appendix IV B, Method II.
ASSAY
Dilute a volume containing 50 mg of Silver Nitrate with 20 mL of water and add 2 mL of dilute nitric acid and 2 mL of ammonium iron(III) sulfate solution R2. Titrate with 0.02M ammonium thiocyanate VS until a reddish-yellow colour is obtained. Each mL of 0.02M ammonium thiocyanate VS is equivalent to 3.397 mg of AgNO3.
STORAGE
Silver Nitrate Solution should be protected from light.
