NOTE: This monograph has been developed to cover unlicensed formulations.
DEFINITION
Silver Nitrate Eye Drops are a sterile solution of Silver Nitrate in Purified Water.
The eye drops comply with the requirements stated under Eye Preparations and with the following requirements. Where appropriate, the eye drops also comply with the requirements stated under Unlicensed Medicines.
Content of silver nitrate, AgNO3,
95.0 to 105.0% of the stated amount.
IDENTIFICATION
Yields the reactions characteristic of silver salts and of nitrates, Appendix VI.
TESTS
Acidity
pH, 4.5 to 6.0, Appendix V L.
Clarity and colour of solution
The solution is clear, Appendix IV A, and colourless, Appendix IV B, Method II.
ASSAY
Dilute a volume containing 50 mg of Silver Nitrate with 20 mL of water and add 2 mL of dilute nitric acid and 2 mL of ammonium iron(III) sulfate solution R2. Titrate with 0.02M ammonium thiocyanate VS until a reddish-yellow colour is obtained. Each mL of 0.02M ammonium thiocyanate VS is equivalent to 3.397 mg of AgNO3
STORAGE
Silver Nitrate Eye Drops should be protected from light.
