Edition: BP 2025 (Ph. Eur. 11.6 update)
DEFINITION
Magnesium Hydroxide Mixture is an aqueous oral suspension of Magnesium Hydroxide in a suitable vehicle.
The mixture complies with the requirements stated under Oral Liquids and with the following requirements.
Content of magnesium hydroxide, Mg(OH)2
7.45 to 8.35% w/w.
CHARACTERISTICS
A white, uniform suspension which does not separate readily on standing.
TESTS
Sulfate
Dissolve 2.5 mL in 20 mL of hydrochloric acid and dilute to 500 mL with water. 15 mL of the solution, filtered if necessary, complies with the limit test for sulfates, Appendix VII (0.2%).
ASSAY
Mix 10 g with 50 mL of water, add 50 mL of 0.5M sulfuric acid VS and titrate the excess of acid with 1M sodium hydroxide VS using methyl orange solution as indicator. Each mL of 0.5M sulfuric acid VS is equivalent to 29.16 mg of Mg(OH)2.
STORAGE
Magnesium Hydroxide Mixture should not be refrigerated.
