Edition: BP 2025 (Ph. Eur. 11.6 update)
Aluminium Chloride Solution
General Notices
Aluminium Chloride Cutaneous Solution
DEFINITION
Aluminium Chloride Solution is a cutaneous solution. It contains Aluminium Chloride Hexahydrate in a suitable ethanolic vehicle.
PRODUCTION
In making Aluminium Chloride Solution, Industrial Methylated Spirits may be used provided that the law and the statutory regulations governing the use of Industrial Methylated Spirits are observed.
The solution complies with the requirements stated under Liquids for Cutaneous Application and with the following requirements.
Content of aluminium chloride hexahydrate, AlCl3,6H2O
95.0 to 105.0% of the stated amount.
IDENTIFICATION
Dilute the solution with water to produce a solution containing 2% w/v of Aluminium Chloride Hexahydrate. The solution yields reaction A characteristic of aluminium salts and reaction A characteristic of chlorides, Appendix VI.
TESTS
Iron
Dilute the solution being examined with water to produce a solution containing 10.0% w/v of Aluminium Chloride Hexahydrate. 10 mL of this solution complies with the limit test for iron, Appendix VII (10 ppm, determined with respect to the content of aluminium chloride hexahydrate).
Ethanol
Not less than 70.0% v/v, Appendix VIII F.
ASSAY
To a weighed quantity containing about 0.4 g of Aluminium Chloride Hexahydrate add 25 mL of water and carry out the complexometric titration of aluminium, Appendix VIII D. Each mL of 0.1M disodium edetate VS is equivalent to 24.14 mg of AlCl3,6H2O.
If the declared content is in terms of weight in volume, determine the weight per mL of the solution, Appendix V G, and hence calculate the content of AlCl3,6H2O, weight in volume.
STORAGE
Aluminium Chloride Solution should be stored upright.
LABELLING
The label states that the solution is flammable.
