{"id":9855,"date":"2025-10-07T09:50:27","date_gmt":"2025-10-07T02:50:27","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=9855"},"modified":"2025-10-07T09:50:27","modified_gmt":"2025-10-07T02:50:27","slug":"diphenylpyraline-hydrochloride","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/diphenylpyraline-hydrochloride\/","title":{"rendered":"Diphenylpyraline Hydrochloride"},"content":{"rendered":"<p>C<sub>19<\/sub>H<sub>23<\/sub>NO,HCl\u00a0 \u00a0317.9\u00a0 \u00a0132-18-3<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Histamine H1 receptor antagonist; antihistamine.<\/p>\n<h2>DEFINITION<\/h2>\n<p>Diphenylpyraline Hydrochloride is 4-benzhydryloxy-1-methylpiperidine hydrochloride. It contains not less than 98.0% and not more than 101.0% of C<sub>19<\/sub>H<sub>23<\/sub>NO,HCl, calculated with reference to the dried substance.<\/p>\n<h2>CHARACTERISTICS<\/h2>\n<p>A white or almost white powder; odourless or almost odourless.<\/p>\n<p>Freely soluble in water and in ethanol (96%); practically insoluble in ether.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. The infrared absorption spectrum, Appendix II A, is concordant with the reference spectrum of diphenylpyraline<br \/>\nhydrochloride (RS 106).<\/p>\n<p>B. Yields the reactions characteristic of chlorides, Appendix VI.<\/p>\n<h2>TESTS<\/h2>\n<h3>Related substances<\/h3>\n<p>Carry out the method for gas chromatography, Appendix III B, using the following solutions.<\/p>\n<p>(1) Dissolve 45 mg of bibenzyl (internal standard) in sufficient dichloromethane to produce 100 mL.<\/p>\n<p>(2) Dissolve 0.20 g of the substance being examined in 20 mL of water, make the solution alkaline with 5M ammonia and extract with three 25-mL quantities of dichloromethane. Shake the combined extracts with 10 g of anhydrous sodium sulfate, filter, evaporate the filtrate to dryness at about 30\u00b0 and dissolve the residue in 2 mL of dichloromethane.<\/p>\n<p>(3) Prepare solution (3) in the same manner as solution (2) but dissolve the residue in 2 mL of solution (1).<\/p>\n<h4>CHROMATOGRAPHIC CONDITIONS<\/h4>\n<p>(a) Use a glass column (1.5 m\u00d74 mm) packed with silanised diatomaceous support (80 to 100 mesh) coated with 3% w\/w of phenyl methyl silicone fluid (50% phenyl) (OV-17 is suitable).<\/p>\n<p>(b) Use nitrogen as the carrier gas.<\/p>\n<p>(c) Use an oven temperature of 165\u00b0. Allow the chromatography to proceed for 3 times the retention time of bibenzyl.<\/p>\n<p>(d) Increase the oven temperature to 240\u00b0 to elute the diphenylpyraline from the column.<\/p>\n<h4>LIMITS<\/h4>\n<p>In the chromatogram obtained with solution (3):<\/p>\n<p>the sum of the areas of any secondary peaks is not greater than the area of the peak due to the internal standard.<\/p>\n<h3>Loss on drying<\/h3>\n<p>When dried to constant weight at 105\u00b0, loses not more than 1.0% of its weight. Use 1 g.<\/p>\n<h3>Sulfated ash<\/h3>\n<p>Not more than 0.1%, Appendix IX A.<\/p>\n<h2>ASSAY<\/h2>\n<p>Carry out Method I for non-aqueous titration, Appendix VIII A, using 0.2 g, adding 5 mL of mercury(II) acetate solution and determining the end-point potentiometrically. Each mL of 0.1M perchloric acid VS is equivalent to 31.79 mg of C<sub>19<\/sub>H<sub>23<\/sub>NO,HCl.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>C19H23NO,HCl\u00a0 \u00a0317.9\u00a0 \u00a0132-18-3 Action and use Histamine H1 receptor antagonist; antihistamine. DEFINITION Diphenylpyraline Hydrochloride is 4-benzhydryloxy-1-methylpiperidine hydrochloride. It contains not less than 98.0% and not more than 101.0% of C19H23NO,HCl, calculated with reference to the dried substance. CHARACTERISTICS A white or almost white powder; odourless or almost odourless. Freely soluble in water and in ethanol&#8230;<\/p>\n","protected":false},"author":3,"featured_media":9878,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-9855","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/9855","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=9855"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/9855\/revisions"}],"predecessor-version":[{"id":9880,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/9855\/revisions\/9880"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/9878"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=9855"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=9855"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=9855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}