{"id":975,"date":"2025-09-17T10:09:23","date_gmt":"2025-09-17T03:09:23","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=975"},"modified":"2025-10-02T09:22:01","modified_gmt":"2025-10-02T02:22:01","slug":"calcium-gluconate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/calcium-gluconate\/","title":{"rendered":"Calcium Gluconate"},"content":{"rendered":"

(Ph. Eur. monograph 0172)<\/p>\n

C12<\/sub>H22<\/sub>CaO14<\/sub>,H2<\/sub>O\u00a0 \u00a0 \u00a0 448.4\u00a0 \u00a0 \u00a0 18016-24-5<\/p>\n

Action and use<\/strong><\/p>\n

Used in treatment of calcium deficiency.<\/p>\n

Preparations<\/strong><\/p>\n

Calcium Gluconate Tablets<\/p>\n

Calcium Gluconate Chewable Tablets<\/p>\n

Calcium Gluconate Effervescent Tablets<\/p>\n

DEFINITION<\/h2>\n

Calcium bis[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate] monohydrate (calcium di(D-gluconate) monohydrate).<\/p>\n

Content<\/h3>\n

98.5 per cent to 102.0 per cent of C12<\/sub>H22<\/sub>CaO14<\/sub>,H2<\/sub>O.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

White or almost white, crystalline or granular powder.<\/p>\n

Solubility<\/h3>\n

Sparingly soluble in water, freely soluble in boiling water.<\/p>\n

Calcium Gluconate<\/p>\n

IDENTIFICATION<\/h2>\n

A. Thin-layer chromatography (2.2.27).<\/p>\n

Test solution: Dissolve 20 mg of the substance to be examined in 1 mL of water R, heating if necessary in a water-bath at 60 \u00b0C.<\/p>\n

Reference solution: Dissolve 20 mg of calcium gluconate CRS in 1 mL of water R, heating if necessary in a water-bath at 60 \u00b0C.<\/p>\n

Plate: TLC silica gel plate R (5-40 \u03bcm) [or TLC silica gel plate R (2-10 \u03bcm)].<\/p>\n

Mobile phase: concentrated ammonia R, ethyl acetate R, water R, ethanol (96 per cent) R (10:10:30:50 V\/V\/V\/V).<\/p>\n

Application: 1 \u03bcL.<\/p>\n

Development: Over 2\/3 of the plate.<\/p>\n

Drying: At 100 \u00b0C for 20 min; allow to cool.<\/p>\n

Detection: Spray with a solution containing 10 g\/L of cerium sulfate R and 25 g\/L of ammonium molybdate R in dilute sulfuric acid R and heat at 105 \u00b0C for about 10 min.<\/p>\n

Results: After 5 min, the principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution.<\/p>\n

B. Solution S (see Tests) gives reaction (b) of calcium (2.3.1).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\n

Dissolve 1.0 g in water R heated to 60 \u00b0C and dilute to 50 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\n

At 60 \u00b0C, solution S is not more intensely coloured than reference solution Y6 (2.2.2, Method II). After cooling, it is not more opalescent than reference suspension II (2.2.1).<\/p>\n

Organic impurities and boric acid<\/h3>\n

Introduce 0.5 g into a porcelain dish previously rinsed with sulfuric acid R and placed in a bath of iced water. Add 2 mL of cooled sulfuric acid R and mix. No yellow or brown colour develops. Add 1 mL of chromotrope II B solution R. A violet colour develops and does not become dark blue. The solution is not more intensely coloured than that of a mixture of 1 mL of chromotrope II B solution R and 2 mL of cooled sulfuric acid R.<\/p>\n

Sucrose and reducing sugars<\/h3>\n

Dissolve 0.5 g in a mixture of 2 mL of hydrochloric acid R1 and 10 mL of water R. Boil for 5 min, allow to cool, add 10 mL of sodium carbonate solution R and allow to stand. Dilute to 25 mL with water R and filter. To 5 mL of the filtrate add 2 mL of cupri-tartaric solution R and boil for 1 min. Allow to stand for 2 min. No red precipitate is formed.<\/p>\n

Chlorides (2.4.4)<\/h3>\n

Maximum 200 ppm.<\/p>\n

Dilute 12.5 mL of solution S to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\n

Maximum 100 ppm.<\/p>\n

Dissolve 10.0 g with heating in a mixture of 10 mL of acetic acid R and 90 mL of distilled water R.<\/p>\n

Magnesium and alkali metals<\/h3>\n

Maximum 0.4 per cent.<\/p>\n

Dissolve 1.00 g in 100 mL of boiling water R, add 10 mL of ammonium chloride solution R, 1 mL of ammonia R and, dropwise, 50 mL of hot ammonium oxalate solution R. Allow to stand for 4 h, dilute to 200 mL with water R and filter. Evaporate 100 mL of the filtrate to dryness and ignite. The residue weighs a maximum of 2 mg.<\/p>\n

Microbial contamination<\/h3>\n

TAMC: acceptance criterion 10 CFU\/g (2.6.12).<\/p>\n

TYMC: acceptance criterion 10 CFU\/g (2.6.12).<\/p>\n

ASSAY<\/h2>\n

Dissolve 0.8000 g in 20 mL of hot water R, allow to cool and dilute to 300 mL with water R. Carry out the complexometric titration of calcium (2.5.11).<\/p>\n

1 mL of 0.1 M sodium edetate is equivalent to 44.84 mg of C12<\/sub>H22<\/sub>CaO14<\/sub>,H2<\/sub>O.<\/p>\n","protected":false},"excerpt":{"rendered":"

(Ph. Eur. monograph 0172) C12H22CaO14,H2O\u00a0 \u00a0 \u00a0 448.4\u00a0 \u00a0 \u00a0 18016-24-5 Action and use Used in treatment of calcium deficiency. Preparations Calcium Gluconate Tablets Calcium Gluconate Chewable Tablets Calcium Gluconate Effervescent Tablets DEFINITION Calcium bis[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate] monohydrate (calcium di(D-gluconate) monohydrate). Content 98.5 per cent to 102.0 per cent of C12H22CaO14,H2O. CHARACTERS Appearance White or almost white,…<\/p>\n","protected":false},"author":1,"featured_media":978,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-975","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/975","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=975"}],"version-history":[{"count":3,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/975\/revisions"}],"predecessor-version":[{"id":5145,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/975\/revisions\/5145"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/978"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=975"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=975"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=975"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}