{"id":9099,"date":"2025-10-04T15:46:37","date_gmt":"2025-10-04T08:46:37","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=9099"},"modified":"2025-10-04T15:46:37","modified_gmt":"2025-10-04T08:46:37","slug":"dexamethasone","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/dexamethasone\/","title":{"rendered":"Dexamethasone"},"content":{"rendered":"<p>(Ph. Eur. monograph 0388)<\/p>\n<p>C<sub>22<\/sub>H<sub>29<\/sub>FO<sub>5<\/sub>\u00a0 \u00a0 \u00a0392.5\u00a0 \u00a0 \u00a050-02-2<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Glucocorticoid.<\/p>\n<p><strong>Preparations<\/strong><\/p>\n<p>Dexamethasone Eye Drops, Suspension<\/p>\n<p>Dexamethasone and Neomycin Ear Spray<\/p>\n<p>Dexamethasone Tablets<\/p>\n<p>Tobramycin and Dexamethasone Eye Drops, Suspension<\/p>\n<h2>DEFINITION<\/h2>\n<p>9-Fluoro-11\u03b2,17,21-trihydroxy-16\u03b1-methylpregna-1,4-diene-3,20-dione.<\/p>\n<h3>Content<\/h3>\n<p>97.0 per cent to 103.0 per cent (dried substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>White or almost white, crystalline powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Practically insoluble in water, sparingly soluble in anhydrous ethanol, slightly soluble in methylene chloride.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>First identification: A, B.<\/p>\n<p>Second identification: B, C.<\/p>\n<p>A. Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison dexamethasone CRS.<\/p>\n<p>B. Thin-layer chromatography (2.2.27).<\/p>\n<p>Test solution: Dissolve 10 mg of the substance to be examined in the mobile phase and dilute to 10.0 mL with the mobile phase.<\/p>\n<p>Reference solution: Dissolve 10 mg of dexamethasone CRS in the mobile phase and dilute to 10.0 mL with the mobile phase.<\/p>\n<p>Plate TLC silica gel F254 plate R.<\/p>\n<p>Mobile phase methanol R, methylene chloride R (10:90 V\/V).<\/p>\n<p>Application 5 \u03bcL.<\/p>\n<p>Development: Over 3\/4 of the plate.<\/p>\n<p>Drying In air.<\/p>\n<p>Detection: Spray with a solution prepared as follows: dissolve 0.25 g of 2,4-dihydroxybenzaldehyde R in glacial acetic acid R, dilute to 50 mL with the same solvent and add a mixture of 12.5 mL of sulfuric acid R and 37.5 mL of glacial acetic acid R; heat at 90 \u00b0C for 35 min or until the spots appear, allow to cool and examine in daylight and in ultraviolet light at 365 nm.<\/p>\n<p>Results The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution.<\/p>\n<p>C. Add about 2 mg to 2 mL of sulfuric acid R and shake to dissolve. Within 5 min, a faint reddish-brown colour develops. Add this solution to 10 mL of water R and mix; the colour is discharged.<\/p>\n<h2>TESTS<\/h2>\n<h3>Specific optical rotation (2.2.7)<\/h3>\n<p>+ 86 to + 92 (dried substance).<\/p>\n<p>Dissolve 0.250 g in anhydrous ethanol R and dilute to 25.0 mL with the same solvent.<\/p>\n<h3>Related substances<\/h3>\n<p>Liquid chromatography (2.2.29). Carry out the test protected from light.<\/p>\n<p>Test solution: Dissolve 25.0 mg of the substance to be examined in 1.5 mL of acetonitrile R and add 5 mL of mobile<br \/>\nphase A. Sonicate until dissolution is complete and dilute to 10.0 mL with mobile phase A.<\/p>\n<p>Reference solution (a): Dissolve 5 mg of dexamethasone for system suitability CRS (containing impurities B, F and G) in 0.5 mL of acetonitrile R and add 1 mL of mobile phase A. Sonicate until dissolution is complete and dilute to 2 mL with mobile phase A.<\/p>\n<p>Reference solution (b): Dilute 1.0 mL of the test solution to 100.0 mL with mobile phase A. Dilute 1.0 mL of this solution to 10.0 mL with mobile phase A.<\/p>\n<p>Reference solution (c): Dissolve 5 mg of dexamethasone for peak identification CRS (containing impurities J and K) in 0.5 mL of acetonitrile R and add 1 mL of mobile phase A. Sonicate until dissolution is complete and dilute to 2 mL with mobile phase A.<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.15 m, \u00d8 = 4.6 mm;<\/p>\n<p>\u2014 stationary phase: end-capped octadecylsilyl silica gel for chromatography R (5 \u03bcm);<\/p>\n<p>\u2014 temperature: 45 \u00b0C.<\/p>\n<p>Mobile phase:<\/p>\n<p>\u2014 mobile phase A: mix 250 mL of acetonitrile R and 700 mL of water for chromatography R and allow to equilibrate; dilute to 1000 mL with water for chromatography R and mix;<\/p>\n<p>\u2014 mobile phase B: acetonitrile R;<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">Time<br \/>\n(min)<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">Mobile phase A<br \/>\n(per cent V\/V)<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">Mobile phase B<br \/>\n(per cent V\/V)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">0 &#8211; 15<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">100<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">0<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">15 &#8211; 40<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">100 \u2192 0<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">0 \u2192 100<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Flow rate 1.2 mL\/min.<\/p>\n<p>Detection: Spectrophotometer at 254 nm.<\/p>\n<p>Injection 20 \u03bcL; inject mobile phase A as a blank.<\/p>\n<p>Identification of impurities: Use the chromatogram supplied with dexamethasone for system suitability CRS and the<br \/>\nchromatogram obtained with reference solution (a) to identify the peaks due to impurities B, F and G; use the<br \/>\nchromatogram supplied with dexamethasone for peak identification CRS and the chromatogram obtained with reference solution (c) to identify the peaks due to impurities J and K.<\/p>\n<p>Relative retention: With reference to dexamethasone (retention time = about 15 min): impurity J = about 0.90;<br \/>\nimpurity B = about 0.94; impurity K = about 1.3; impurity F = about 1.5; impurity G = about 1.7.<\/p>\n<p>System suitability Reference solution (a):<\/p>\n<p>\u2014 peak-to-valley ratio: minimum 2.0, where Hp = height above the baseline of the peak due to impurity B and<br \/>\nHv = height above the baseline of the lowest point of the curve separating this peak from the peak due to<br \/>\ndexamethasone.<\/p>\n<p>Limits:<\/p>\n<p>\u2014 impurity G: not more than 3 times the area of the principal peak in the chromatogram obtained with reference<br \/>\nsolution (b) (0.3 per cent);<\/p>\n<p>\u2014 impurities B, F, J, K: for each impurity, not more than 1.5 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.15 per cent);<\/p>\n<p>\u2014 unspecified impurities: for each impurity, not more than the area of the principal peak in the chromatogram obtained with reference solution (b) (0.10 per cent);<\/p>\n<p>\u2014 total: not more than 5 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.5 per cent);<\/p>\n<p>\u2014 disregard limit: 0.5 times the area of the principal peak in the chromatogram obtained with reference solution (b)<br \/>\n(0.05 per cent).<\/p>\n<h4>Loss on drying (2.2.32)<\/h4>\n<p>Maximum 0.5 per cent, determined on 0.500 g by drying in an oven at 105 \u00b0C.<\/p>\n<h2>ASSAY<\/h2>\n<p>Dissolve 0.100 g in ethanol (96 per cent) R and dilute to 100.0 mL with the same solvent. Dilute 2.0 mL of the solution to 100.0 mL with ethanol (96 per cent) R. Measure the absorbance (2.2.25) at the absorption maximum at 238.5 nm.<\/p>\n<p>Calculate the content of C<sub>22<\/sub>H<sub>29<\/sub>FO<sub>5<\/sub> taking the specific absorbance to be 394.<\/p>\n<p>STORAGE<\/p>\n<p>Protected from light.<\/p>\n<p>IMPURITIES<\/p>\n<p>Specified impurities B, F, G, J, K.<\/p>\n<p>Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for other\/unspecified impurities and\/or by the general monograph Substances for pharmaceutical use (2034). It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10. Control of impurities in substances for pharmaceutical use) A, C, D, E, H, I.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9104\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/1-13-300x163.jpg\" alt=\"Dexamethasone-1\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/1-13-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/1-13-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/1-13-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/1-13.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>A. 14-fluoro-11\u03b2,17,21-trihydroxy-16\u03b1-methylpregna-1,4-diene-3,20-dione,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9105\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-13-300x163.jpg\" alt=\"Dexamethasone-2\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-13-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-13-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-13-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/2-13.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>B. 9-fluoro-11\u03b2,17,21-trihydroxy-16\u03b2-methylpregna-1,4-diene-3,20-dione (betamethasone),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9106\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-9-300x163.jpg\" alt=\"Dexamethasone-3\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-9-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-9-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-9-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/3-9.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>C. 9-fluoro-11\u03b2,17,21-trihydroxy-16\u03b1-methylpregn-4-ene-3,20-dione,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9107\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-9-300x163.jpg\" alt=\"Dexamethasone-4\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-9-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-9-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-9-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/4-9.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>D. 9,11\u03b2-epoxy-17,21-dihydroxy-16\u03b1-methyl-9\u03b2-pregna-1,4-diene-3,20-dione,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9108\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-6-300x163.jpg\" alt=\"Dexamethasone-5\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-6-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-6-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-6-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/5-6.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>E. 17,21-dihydroxy-16\u03b1-methylpregna-1,4,9(11)-triene-3,20-dione,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9109\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-4-300x163.jpg\" alt=\"Dexamethasone-6\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-4-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-4-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-4-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/6-4.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>F. 9-fluoro-11\u03b2,21-dihydroxy-16\u03b1-methylpregna-1,4-diene-3,20-dione,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9110\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-3-300x163.jpg\" alt=\"Dexamethasone-7\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-3-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-3-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-3-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/7-3.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>G. 9-fluoro-11\u03b2,17-dihydroxy-16\u03b1-methyl-3,20-dioxopregna-1,4-dien-21-yl acetate (dexamethasone acetate),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9111\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-3-300x163.jpg\" alt=\"Dexamethasone-8\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-3-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-3-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-3-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/8-3.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>H. 17-hydroxy-16\u03b1-methyl-3,20-dioxopregna-1,4,9(11)-trien-21-yl acetate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9112\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-1-300x163.jpg\" alt=\"Dexamethasone-9\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-1-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-1-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-1-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/9-1.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>I. 9,11\u03b1-epoxy-17,21-dihydroxy-16\u03b1-methylpregna-1,4-diene-3,20-dione,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9113\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-300x163.jpg\" alt=\"Dexamethasone-10\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/10.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>J. 17,21-dihydroxy-16\u03b1-methylpregna-1,4-diene-3,11,20-trione,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-9114\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-300x163.jpg\" alt=\"Dexamethasone-11\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/10\/11.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>K. 17,21-dihydroxy-16\u03b1-methylpregna-1,4,7,9(11)-tetraene-3,20-dione.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 0388) C22H29FO5\u00a0 \u00a0 \u00a0392.5\u00a0 \u00a0 \u00a050-02-2 Action and use Glucocorticoid. Preparations Dexamethasone Eye Drops, Suspension Dexamethasone and Neomycin Ear Spray Dexamethasone Tablets Tobramycin and Dexamethasone Eye Drops, Suspension DEFINITION 9-Fluoro-11\u03b2,17,21-trihydroxy-16\u03b1-methylpregna-1,4-diene-3,20-dione. Content 97.0 per cent to 103.0 per cent (dried substance). CHARACTERS Appearance White or almost white, crystalline powder. Solubility Practically insoluble in&#8230;<\/p>\n","protected":false},"author":3,"featured_media":9115,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-9099","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/9099","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=9099"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/9099\/revisions"}],"predecessor-version":[{"id":9120,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/9099\/revisions\/9120"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/9115"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=9099"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=9099"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=9099"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}