Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n
General Notices<\/p>\n
Calcium Gluconate Injection is a sterile solution of Calcium Gluconate for Injection in Water for Injections. Not more than 5.0% of the Calcium Gluconate may be replaced with calcium M-saccharate, or other suitable calcium salt, as a stabilising agent.<\/p>\n
The injection complies with the requirements stated under Parenteral Preparations and with the following requirements.<\/p>\n
Content of calcium, Ca<\/b><\/p>\n
8.5 to 9.4% of the content of Calcium Gluconate stated on the label.<\/p>\n
A. To 1 mL add 0.05 mL of iron(iii) chloride solution R1. An intense yellow colour is produced.<\/p>\n
B. Warm a volume containing the equivalent of 0.5 g of Calcium Gluconate, add 0.65 mL of glacial acetic acid and 1 mL of phenylhydrazine. Heat on a water bath for 30 minutes, allow to cool and induce crystallisation. Filter, dissolve the residue in 10 mL of hot water, add a few mg of activated charcoal, shake, filter, allow the filtrate to cool and induce crystallisation. A white, crystalline precipitate is produced. The melting point of the crystals, after drying, is about 200\u00b0, with decomposition, Appendix V A.<\/p>\n
C. Yields the reactions characteristic of calcium salts, Appendix VI.<\/p>\n
Carry out the test for bacterial endotoxins, Appendix XIV C. Dilute the injection in water BET if necessary to give a solution containing 100 mg of Calcium Gluconate per millilitre (solution A). The endotoxin limit concentration of solution A is 16.7 IU per mL.<\/p>\n
To a volume containing the equivalent of 0.5 g of Calcium Gluconate add 300 mL of water and carry out the complexometric titration of calcium, Appendix VIII D, beginning at the words \u2018add 6 mL of …’.<\/p>\n
The label states (1) the percentage w\/v of Calcium Gluconate equivalent to the total amount of calcium present; (2) that solutions containing visible solid particles must not be used; (3) the name and the percentage of any added stabilising agent.<\/p>\n","protected":false},"excerpt":{"rendered":"
Edition: BP 2025 (Ph. Eur. 11.6 update) General Notices DEFINITION Calcium Gluconate Injection is a sterile solution of Calcium Gluconate for Injection in Water for Injections. Not more than 5.0% of the Calcium Gluconate may be replaced with calcium M-saccharate, or other suitable calcium salt, as a stabilising agent. The injection complies with the requirements…<\/p>\n","protected":false},"author":5,"featured_media":7320,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[175],"tags":[],"class_list":["post-7313","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-formulated-preparations-specific-monographs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/7313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=7313"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/7313\/revisions"}],"predecessor-version":[{"id":7324,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/7313\/revisions\/7324"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/7320"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=7313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=7313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=7313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}