{"id":6774,"date":"2025-09-30T22:03:04","date_gmt":"2025-09-30T15:03:04","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=6774"},"modified":"2025-09-30T22:03:04","modified_gmt":"2025-09-30T15:03:04","slug":"betamethasone-valerate-ointment","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/betamethasone-valerate-ointment\/","title":{"rendered":"Betamethasone Valerate Ointment"},"content":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Glucocorticoid.<\/p>\n<h2>DEFINITION<\/h2>\n<p>Betamethasone Valerate Ointment contains Betamethasone Valerate in a suitable basis.<\/p>\n<p>The ointment complies with the requirements stated under Topical Semi-solid Preparations and with the following requirements.<\/p>\n<p>Content of betamethasone, C<sub>22<\/sub>H<sub>29<\/sub>FO<sub>5<\/sub><\/p>\n<p>90.0 to 110.0% of the stated amount.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. Complies with test A for Identification described under Betamethasone Valerate Lotion preparing solution (1) in the following manner. Disperse a quantity of the ointment containing the equivalent of 1 mg of betamethasone in 10 mL of methanol by heating on a water bath until the methanol begins to boil, shake vigorously, cool in ice for 30 minutes and filter. Evaporate the filtrate to dryness in a current of nitrogen with gentle heating and dissolve the residue in 0.5 mL of chloroform. Solution (2) contains 0.24% w\/v of betamethasone valerate BPCRS in chloroform.<br \/>\nB. In the Assay, the chromatogram obtained with solution (2) shows a peak with the same retention time as the peak due to betamethasone valerate in the chromatogram obtained with solution (1).<\/p>\n<h2>ASSAY<\/h2>\n<p>Carry out the method for liquid chromatography, Appendix III D, using the following solutions. For solution (1) mix 10 mL of a solution containing 0.024% w\/v of betamethasone valerate BPCRS and 0.0012% w\/v of betamethasone 21-valerate BPCRS in ethanol (65%) with 5 mL of a 0.072% w\/v solution of beclometasone dipropionate BPCRS (internal standard) in ethanol (65%) and dilute to 50 mL with ethanol (65%). For solution (2) disperse a quantity of the ointment containing the equivalent of 2 mg of betamethasone in 100 mL of hot hexane, cool, extract with 20 mL of ethanol (65%) and filter the lower, ethanolic layer through absorbent cotton previously washed with ethanol (65%); repeat the extraction of the hexane mixture with two 10-mL quantities of ethanol (65%), filtering each extract in turn through the absorbent cotton and dilute the combined filtrates to 50 mL with ethanol (65%). Prepare solution (3) in the same manner as solution (2) but add 5 mL of the 0.072% w\/v solution of the internal standard in ethanol (65%) before diluting to 50 mL.<\/p>\n<p>The chromatographic procedure may be carried out using (a) a stainless steel column (10 cm \u00d7 5 mm) packed with octadecylsilyl silica gel for chromatography (5 \u03bcm) (Spherisorb ODS 1 is suitable) and maintained at 60\u00b0, (b) as the mobile phase with a flow rate of 2 mL per minute a mixture of absolute ethanol and water adjusted so that the resolution factor between the peaks due to betamethasone valerate (retention time about 5 minutes) and betamethasone 21 valerate (retention time about 7 minutes) is more than 1.0 (a mixture of 42 volumes of absolute ethanol and 58 volumes of water is usually suitable) and (c) a detection wavelength of 238 nm.<\/p>\n<p>Calculate the content of C<sub>22<\/sub>H<sub>29<\/sub>FO<sub>5<\/sub> in the ointment using the declared content of C<sub>22<\/sub>H<sub>29<\/sub>FO<sub>5<\/sub> in betamethasone valerate BPCRS.<\/p>\n<h2>STORAGE<\/h2>\n<p>Betamethasone Valerate Ointment should be protected from light.<\/p>\n<h2>LABELLING<\/h2>\n<p>The quantity of active ingredient is stated in terms of the equivalent amount of betamethasone.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update) Action and use Glucocorticoid. DEFINITION Betamethasone Valerate Ointment contains Betamethasone Valerate in a suitable basis. The ointment complies with the requirements stated under Topical Semi-solid Preparations and with the following requirements. Content of betamethasone, C22H29FO5 90.0 to 110.0% of the stated amount. IDENTIFICATION A. Complies with test A&#8230;<\/p>\n","protected":false},"author":5,"featured_media":6775,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[175],"tags":[],"class_list":["post-6774","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-formulated-preparations-specific-monographs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/6774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=6774"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/6774\/revisions"}],"predecessor-version":[{"id":6778,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/6774\/revisions\/6778"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/6775"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=6774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=6774"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=6774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}