{"id":6033,"date":"2025-09-30T09:24:14","date_gmt":"2025-09-30T02:24:14","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=6033"},"modified":"2025-10-03T10:05:46","modified_gmt":"2025-10-03T03:05:46","slug":"calcium-lactate-trihydrate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/calcium-lactate-trihydrate\/","title":{"rendered":"Calcium Lactate Trihydrate"},"content":{"rendered":"<p><em>(Ph. Eur. monograph 0469)<\/em><\/p>\n<p>C<sub>6<\/sub>H<sub>10<\/sub>CaO<sub>6<\/sub>, 3H<sub>2<\/sub>O\u00a0 \u00a0 272.3Action and use<\/p>\n<p>Used in treatment of calcium deficiency.<\/p>\n<p><strong>Preparation<\/strong><\/p>\n<p>Calcium Lactate Tablets<\/p>\n<h2>DEFINITION<\/h2>\n<p>Calcium bis[(2\u039e)-2-hydroxypropanoate] or mixture of calcium (2R)-, (2S)- and (2RS)-2-hydroxypropanoates trihydrates.<\/p>\n<h3>Content<\/h3>\n<p>98.0 per cent to 102.0 per cent (dried substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>White or almost white, crystalline or granular powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Soluble in water, freely soluble in boiling water, very slightly soluble in ethanol (96 per cent).<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. Loss on drying (see Tests).<\/p>\n<p>B. It gives the reaction of lactates (2.3.1).<\/p>\n<p>C. It gives reaction (b) of calcium (2.3.1).<\/p>\n<h2>TESTS<\/h2>\n<h3>Solution S<\/h3>\n<p>Dissolve 6.2 g (equivalent to 5.0 g of the dried substance) with heating in carbon dioxide-free water R prepared from distilled water R, allow to cool and dilute to 100 mL with the same solvent.<\/p>\n<h3>Appearance of solution<\/h3>\n<p>Solution S is not more opalescent than reference suspension II (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).<\/p>\n<h3>Acidity or alkalinity<\/h3>\n<p>To 10 mL of solution S add 0.1 mL of phenolphthalein solution R and 0.5 mL of 0.01 M hydrochloric acid. The solution is colourless. Not more than 2.0 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to pink.<\/p>\n<h3>Chlorides (2.4.4)<\/h3>\n<p>Maximum 200 ppm.<\/p>\n<p>Dilute 5 mL of solution S to 15 mL with water R.<\/p>\n<h3>Sulfates (2.4.13)<\/h3>\n<p>Maximum 400 ppm.<\/p>\n<p>Dilute 7.5 mL of solution S to 15 mL with distilled water R.<\/p>\n<h3>Iron (2.4.9)<\/h3>\n<p>Maximum 50 ppm.<\/p>\n<p>Dilute 4 mL of solution S to 10 mL with water R.<\/p>\n<h3>Magnesium and alkali salts<\/h3>\n<p>Maximum 1 per cent.<\/p>\n<p>To 20 mL of solution S add 20 mL of water R, 2 g of ammonium chloride R and 2 mL of dilute ammonia R1. Heat to boiling and rapidly add 40 mL of hot ammonium oxalate solution R. Allow to stand for 4 h, dilute to 100.0 mL with water R and filter. To 50.0 mL of the filtrate add 0.5 mL of sulfuric acid R. Evaporate to dryness and ignite the residue to constant mass<br \/>\nat 600 \u00b1 50 \u00b0C. The residue weighs a maximum of 5 mg.<\/p>\n<h3>Loss on drying (2.2.32)<\/h3>\n<p>15.0 per cent to 20.0 per cent, determined on 0.500 g by drying in an oven at 125 \u00b0C.<\/p>\n<h2>ASSAY<\/h2>\n<p>Dissolve a quantity equivalent to 0.200 g of the dried substance in water R and dilute to 300 mL with the same solvent.<\/p>\n<p>Carry out the complexometric titration of calcium (2.5.11).<\/p>\n<p>1 mL of 0.1 M sodium edetate is equivalent to 21.82 mg of C<sub>6<\/sub>H<sub>10<\/sub>CaO<sub>6<\/sub><\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 0469) C6H10CaO6, 3H2O\u00a0 \u00a0 272.3Action and use Used in treatment of calcium deficiency. Preparation Calcium Lactate Tablets DEFINITION Calcium bis[(2\u039e)-2-hydroxypropanoate] or mixture of calcium (2R)-, (2S)- and (2RS)-2-hydroxypropanoates trihydrates. Content 98.0 per cent to 102.0 per cent (dried substance). CHARACTERS Appearance White or almost white, crystalline or granular powder. Solubility Soluble in&#8230;<\/p>\n","protected":false},"author":4,"featured_media":6039,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-6033","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/6033","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=6033"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/6033\/revisions"}],"predecessor-version":[{"id":6705,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/6033\/revisions\/6705"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/6039"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=6033"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=6033"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=6033"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}