{"id":5999,"date":"2025-09-30T16:59:54","date_gmt":"2025-09-30T09:59:54","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=5999"},"modified":"2025-10-03T10:02:05","modified_gmt":"2025-10-03T03:02:05","slug":"calcium-lactate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/calcium-lactate\/","title":{"rendered":"Calcium Lactate"},"content":{"rendered":"

Anhydrous Calcium Lactate<\/p>\n

(Ph. Eur. monograph 2118)<\/em><\/p>\n

C_{6<\/sub>H_{10<\/sub>CaO_{6<\/sub>\u00a0 \u00a0218.2<\/p>\n}}}

Action and use<\/strong><\/p>\n

Used in treatment of calcium deficiency.<\/p>\n

DEFINITION<\/h2>\n
Calcium bis(2-hydroxypropanoate) or mixture of calcium (2R)-, (2S)- and (2RS)-2-hydroxypropanoates.<\/p>\n
Content<\/h3>\n
98.0 per cent to 102.0 per cent (dried substance).<\/p>\n
CHARACTERS<\/h2>\n
Appearance<\/h3>\n
White or almost white, crystalline or granular powder.<\/p>\n
Solubility<\/h3>\n
Soluble in water, freely soluble in boiling water, very slightly soluble in ethanol (96 per cent).<\/p>\n
IDENTIFICATION<\/h2>\n
A. Loss on drying (see Tests).<\/p>\n
B. It gives the reaction of lactates (2.3.1).<\/p>\n
C. It gives reaction (b) of calcium (2.3.1).<\/p>\n
TESTS<\/h2>\n
Solution S<\/h3>\n
Dissolve 5.0 g with heating in carbon dioxide-free water R prepared from distilled water R, allow to cool and dilute to 100 mL with the same solvent.<\/p>\n
Appearance of solution<\/h3>\n
Solution S is not more opalescent than reference suspension II (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).<\/p>\n
Acidity or alkalinity<\/h3>\n
To 10 mL of solution S add 0.1 mL of phenolphthalein solution R and 0.5 mL of 0.01 M hydrochloric acid. The solution is colourless. Not more than 2.0 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to pink.<\/p>\n
Chlorides (2.4.4)<\/h3>\n
Maximum 200 ppm.<\/p>\n
Dilute 5 mL of solution S to 15 mL with water R.<\/p>\n
Sulfates (2.4.13)<\/h3>\n
Maximum 400 ppm.<\/p>\n
Dilute 7.5 mL of solution S to 15 mL with distilled water R.<\/p>\n
Barium<\/h3>\n
To 10 mL of solution S add 1 mL of calcium sulfate solution R. Allow to stand for 15 min. Any opalescence in the solution is not more intense than that in a mixture of 1 mL of distilled water R and 10 mL of solution S.<\/p>\n
Iron (2.4.9)<\/h3>\n
Maximum 50 ppm.<\/p>\n
Dilute 4 mL of solution S to 10 mL with water R.<\/p>\n
Magnesium and alkali salts<\/h3>\n
Maximum 1 per cent.<\/p>\n
To 20 mL of solution S add 20 mL of water R, 2 g of ammonium chloride R and 2 mL of dilute ammonia R1. Heat to boiling and rapidly add 40 mL of hot ammonium oxalate solution R.<\/p>\n
Allow to stand for 4 h, dilute to 100.0 mL with water R and filter. To 50.0 mL of the filtrate add 0.5 mL of sulfuric acid R. Evaporate to dryness and ignite the residue to constant mass
\nat 600 \u00b1 50 \u00b0C. The residue weighs a maximum of 5 mg.<\/p>\n
Loss on drying (2.2.32)<\/h3>\n
Maximum 3.0 per cent, determined on 0.500 g by drying in an oven at 125 \u00b0C.<\/p>\n
ASSAY<\/h2>\n
Dissolve 0.200 g in water R and dilute to 300 mL with the same solvent. Carry out the complexometric titration of calcium (2.5.11).<\/p>\n
1 mL of 0.1 M sodium edetate is equivalent to 21.82 mg of C_{6<\/sub>H_{10<\/sub>CaO_{6<\/sub><\/p>\n","protected":false},"excerpt":{"rendered":"}}}
Anhydrous Calcium Lactate (Ph. Eur. monograph 2118) C6H10CaO6\u00a0 \u00a0218.2 Action and use Used in treatment of calcium deficiency. DEFINITION Calcium bis(2-hydroxypropanoate) or mixture of calcium (2R)-, (2S)- and (2RS)-2-hydroxypropanoates. Content 98.0 per cent to 102.0 per cent (dried substance). CHARACTERS Appearance White or almost white, crystalline or granular powder. Solubility Soluble in water, freely soluble…<\/p>\n","protected":false},"author":4,"featured_media":8327,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-5999","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/5999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=5999"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/5999\/revisions"}],"predecessor-version":[{"id":6712,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/5999\/revisions\/6712"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/8327"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=5999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=5999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=5999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Content<\/h3>\n98.0 per cent to 102.0 per cent (dried substance).<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\nWhite or almost white, crystalline or granular powder.<\/p>\n

Solubility<\/h3>\nSoluble in water, freely soluble in boiling water, very slightly soluble in ethanol (96 per cent).<\/p>\n

IDENTIFICATION<\/h2>\nA. Loss on drying (see Tests).<\/p>\nB. It gives the reaction of lactates (2.3.1).<\/p>\nC. It gives reaction (b) of calcium (2.3.1).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\nDissolve 5.0 g with heating in carbon dioxide-free water R prepared from distilled water R, allow to cool and dilute to 100 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\nSolution S is not more opalescent than reference suspension II (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).<\/p>\n

Acidity or alkalinity<\/h3>\nTo 10 mL of solution S add 0.1 mL of phenolphthalein solution R and 0.5 mL of 0.01 M hydrochloric acid. The solution is colourless. Not more than 2.0 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to pink.<\/p>\n

Chlorides (2.4.4)<\/h3>\nMaximum 200 ppm.<\/p>\nDilute 5 mL of solution S to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\nMaximum 400 ppm.<\/p>\nDilute 7.5 mL of solution S to 15 mL with distilled water R.<\/p>\n

Barium<\/h3>\nTo 10 mL of solution S add 1 mL of calcium sulfate solution R. Allow to stand for 15 min. Any opalescence in the solution is not more intense than that in a mixture of 1 mL of distilled water R and 10 mL of solution S.<\/p>\n

Iron (2.4.9)<\/h3>\nMaximum 50 ppm.<\/p>\nDilute 4 mL of solution S to 10 mL with water R.<\/p>\n

Loss on drying (2.2.32)<\/h3>\nMaximum 3.0 per cent, determined on 0.500 g by drying in an oven at 125 \u00b0C.<\/p>\n

Content<\/h3>\n
98.0 per cent to 102.0 per cent (dried substance).<\/p>\n

Appearance<\/h3>\n
White or almost white, crystalline or granular powder.<\/p>\n

Solubility<\/h3>\n
Soluble in water, freely soluble in boiling water, very slightly soluble in ethanol (96 per cent).<\/p>\n

IDENTIFICATION<\/h2>\n
A. Loss on drying (see Tests).<\/p>\n
B. It gives the reaction of lactates (2.3.1).<\/p>\n
C. It gives reaction (b) of calcium (2.3.1).<\/p>\n

Solution S<\/h3>\n
Dissolve 5.0 g with heating in carbon dioxide-free water R prepared from distilled water R, allow to cool and dilute to 100 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\n
Solution S is not more opalescent than reference suspension II (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).<\/p>\n

Acidity or alkalinity<\/h3>\n
To 10 mL of solution S add 0.1 mL of phenolphthalein solution R and 0.5 mL of 0.01 M hydrochloric acid. The solution is colourless. Not more than 2.0 mL of 0.01 M sodium hydroxide is required to change the colour of the indicator to pink.<\/p>\n

Chlorides (2.4.4)<\/h3>\n
Maximum 200 ppm.<\/p>\n
Dilute 5 mL of solution S to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\n
Maximum 400 ppm.<\/p>\n
Dilute 7.5 mL of solution S to 15 mL with distilled water R.<\/p>\n

Barium<\/h3>\n
To 10 mL of solution S add 1 mL of calcium sulfate solution R. Allow to stand for 15 min. Any opalescence in the solution is not more intense than that in a mixture of 1 mL of distilled water R and 10 mL of solution S.<\/p>\n

Iron (2.4.9)<\/h3>\n
Maximum 50 ppm.<\/p>\n
Dilute 4 mL of solution S to 10 mL with water R.<\/p>\n

Loss on drying (2.2.32)<\/h3>\n
Maximum 3.0 per cent, determined on 0.500 g by drying in an oven at 125 \u00b0C.<\/p>\n