{"id":4154,"date":"2025-09-27T09:35:39","date_gmt":"2025-09-27T02:35:39","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=4154"},"modified":"2025-11-15T12:56:30","modified_gmt":"2025-11-15T05:56:30","slug":"benzylpenicillin-procaine-monohydrate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/benzylpenicillin-procaine-monohydrate\/","title":{"rendered":"Benzylpenicillin (Procaine) Monohydrate"},"content":{"rendered":"<p><em>(Ph. Eur. monograph 0115)<\/em><\/p>\n<p>C<sub>29<\/sub>H<sub>38<\/sub>N<sub>4<\/sub>O<sub>6<\/sub>S,H<sub>2<\/sub>O 588.7 6130-64-9<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Penicillin antibacterial.<\/p>\n<p><strong>Preparation<\/strong><\/p>\n<p>Procaine Benzylpenicillin Injection<\/p>\n<h2>DEFINITION<\/h2>\n<p>2-(Diethylamino)ethyl 4-aminobenzoate (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monohydrate.<\/p>\n<p>Salt obtained from Benzylpenicillin sodium (0114) or Benzylpenicillin potassium (0113) produced by the growth of certain strains of Penicillium notatum or related micro-organisms.<\/p>\n<h3>Content<\/h3>\n<p>\u2014 procaine benzylpenicillin: 96.0 per cent to 102.0 per cent (anhydrous substance) without correction for dispersing or suspending agents;<\/p>\n<p>\u2014 procaine (C13H20N2O2; Mr 236.3): 39.0 per cent to 42.0 per cent (anhydrous substance).<\/p>\n<p>Dispersing or suspending agents (for example, lecithin and polysorbate 80) may be added.<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>White or almost white, slightly hygroscopic, crystalline powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Slightly soluble in water, sparingly soluble in ethanol (96 per cent).<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>First identification: A.<\/p>\n<p>Second identification: B, C, D.<\/p>\n<p>A. Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison procaine benzylpenicillin CRS.<\/p>\n<p>B. Thin-layer chromatography (2.2.27).<\/p>\n<p>Test solution: Dissolve 25 mg of the substance to be examined in 5 mL of acetone R.<\/p>\n<p>Reference solution: Dissolve 25 mg of procaine benzylpenicillin CRS in 5 mL of acetone R.<\/p>\n<p>Plate: TLC silanised silica gel plate R.<\/p>\n<p>Mobile phase: Mix 30 volumes of acetone R and 70 volumes of a 154 g\/L solution of ammonium acetate R previously adjusted to pH 7.0 with ammonia R.<\/p>\n<p>Application: 1 \u03bcL.<\/p>\n<p>Development: Over 2\/3 of the plate.<\/p>\n<p>Drying: In air.<\/p>\n<p>Detection: Expose to iodine vapour until the spots appear and examine in daylight.<\/p>\n<p>System suitability: Reference solution:<\/p>\n<p>\u2014 the chromatogram shows 2 clearly separated spots.<\/p>\n<p>Results: The 2 principal spots in the chromatogram obtained with the test solution are similar in position, colour and size to the 2 principal spots in the chromatogram obtained with the reference solution.<\/p>\n<p>C. Place about 2 mg in a test-tube about 150 mm long and 15 mm in diameter. Moisten with 0.05 mL of water R and add 2 mL of sulfuric acid-formaldehyde reagent R. Mix the contents of the tube by swirling; the solution is practically colourless. Place the test-tube on a water-bath for 1 min; a reddish-brown colour develops.<\/p>\n<p>D. Dissolve 0.1 g in 2 mL of dilute hydrochloric acid R. The solution, which may be turbid, gives the reaction of primary aromatic amines (2.3.1).<\/p>\n<h2>TESTS<\/h2>\n<h2>pH (2.2.3)<\/h2>\n<p>5.0 to 7.5.<\/p>\n<p>Dissolve 50 mg in carbon dioxide-free water R and dilute to 15 mL with the same solvent. Shake until dissolution is complete.<\/p>\n<h3>Related substances<\/h3>\n<p>Liquid chromatography (2.2.29). Prepare the test solutions immediately before use.<\/p>\n<p>Solvent mixture methanol R, water R (50:50 V\/V).<\/p>\n<p>Test solution (a): Dissolve 50.0 mg of the substance to be examined in 25 mL of methanol R and dilute to 50.0 mL with water R.<\/p>\n<p>Test solution (b): Dissolve 0.100 g of the substance to be examined in 10 mL of methanol R and dilute to 20.0 mL with water R.<\/p>\n<p>Reference solution (a): Dissolve 50.0 mg of procaine benzylpenicillin CRS in 25 mL of methanol R and dilute to 50.0 mL with water R.<\/p>\n<p>Reference solution (b): Dissolve 12.0 mg of 4-aminobenzoic acid R (impurity A) in water R and dilute to 100.0 mL with the same solvent. Dilute 1.0 mL of the solution to 100.0 mL with water R.<\/p>\n<p>Reference solution (c): Dissolve 10 mg of procaine benzylpenicillin for peak identification A CRS (containing impurities B, C, D, E, G, H, I and J) in 1 mL of methanol R and add 1 mL of water R.<\/p>\n<p>Reference solution (d): Dissolve the contents of a vial of procaine benzylpenicillin impurity F CRS in 1 mL of reference solution (c).<\/p>\n<p>Reference solution (e): Dilute 1.0 mL of reference solution (a) to 20.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (f): Dilute 1.0 mL of reference solution (e) to 20.0 mL with the solvent mixture.<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.15 m, \u00d8 = 4.6 mm;<\/p>\n<p>\u2014 stationary phase: end-capped octadecylsilyl silica gel for chromatography R (3 \u03bcm);<\/p>\n<p>\u2014 temperature: 50 \u00b0C.<\/p>\n<p>Mobile phase:<\/p>\n<p>\u2014 mobile phase A: mix 10 volumes of a 68 g\/L solution of potassium dihydrogen phosphate R adjusted to pH 3.4 with a 500 g\/L solution of phosphoric acid R, 30 volumes of methanol R1 and 60 volumes of water for chromatography R;<\/p>\n<p>\u2014 mobile phase B: mix 10 volumes of a 68 g\/L solution of potassium dihydrogen phosphate R adjusted to pH 3.4 with a 500 g\/L solution of phosphoric acid R, 35 volumes of water for chromatography R and 55 volumes of methanol R1;<\/p>\n<table style=\"border-collapse: collapse; width: 100%; height: 170px;\">\n<tbody>\n<tr style=\"height: 86px;\">\n<td style=\"width: 33.3333%; text-align: center; height: 86px;\"><strong>Time<\/strong><\/p>\n<p><strong>(min)<\/strong><\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 86px;\"><strong>Mobile phase A<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 86px;\"><strong>Mobile phase B<\/strong><\/p>\n<p><strong>(per cent V\/V)<\/strong><\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; text-align: center; height: 21px;\">0 &#8211; 7<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 21px;\">70<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 21px;\">30<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; text-align: center; height: 21px;\">7 &#8211; 17<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 21px;\">70 \u2192 0<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 21px;\">30 \u2192 100<\/td>\n<\/tr>\n<tr style=\"height: 21px;\">\n<td style=\"width: 33.3333%; text-align: center; height: 21px;\">17 &#8211; 22<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 21px;\">0<\/td>\n<td style=\"width: 33.3333%; text-align: center; height: 21px;\">100<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Flow rate: 1.5 mL\/min.<\/p>\n<p>Detection: Spectrophotometer at 225 nm.<\/p>\n<p>Injection: 20 \u03bcL of test solution (b) and reference solutions (b), (d), (e) and (f).<\/p>\n<p>Identification of impurities: Use the chromatogram obtained with reference solution (b) to identify the peak due to impurity A; use the chromatogram supplied with procaine benzylpenicillin for peak identification A CRS and the chromatogram obtained with reference solution (d) to identify the peaks due to impurities B, C, D, E, F, G, H, I and J.<\/p>\n<p>Relative retention: With reference to benzylpenicillin (retention time = about 7 min): procaine = about 0.19; impurity A = about 0.22; impurity D = about 0.33; impurity F = about 0.35; impurity B = about 0.48 and 0.55; impurity E = about 0.62; impurity C = about 0.81 and 0.83; impurity I = about 0.93; impurity G = about 1.47; impurity H = about 1.90; impurity J = about 2.37.<\/p>\n<p>System suitability:<\/p>\n<p>\u2014 resolution: minimum 1.0 between the peaks due to the epimers of impurity C and minimum 1.2 between the peaks due to impurities D and F in the chromatogram obtained with reference solution (d);<\/p>\n<p>\u2014 signal-to-noise ratio: minimum 10 for the peak due to benzylpenicillin in the chromatogram obtained with reference solution (f).<\/p>\n<p>Calculation of percentage contents:<\/p>\n<p>\u2014 correction factor: multiply the peak area of impurity D by 0.4;<\/p>\n<p>\u2014 for impurity A, use the concentration of impurity A in reference solution (b);<\/p>\n<p>\u2014 for impurities other than A, use the concentration of procaine benzylpenicillin monohydrate in reference solution (e) taking into account the area of the peak due to benzylpenicillin in the chromatogram obtained with reference solution (e).<\/p>\n<p>Limits:<\/p>\n<p>\u2014 impurities F, G, H, I, J: for each impurity, maximum 0.5 per cent;<\/p>\n<p>\u2014 impurities B (sum of isomers), C (sum of epimers): for each impurity, maximum 0.4 per cent;<\/p>\n<p>\u2014 impurities E, D: for each impurity, maximum 0.2 per cent;<\/p>\n<p>\u2014 impurity A: maximum 0.024 per cent;<\/p>\n<p>\u2014 any other impurity: for each impurity, maximum 0.2 per cent;<\/p>\n<p>\u2014 total: maximum 2.0 per cent;<\/p>\n<p>\u2014 reporting threshold: 0.05 per cent; disregard the peak due to procaine.<\/p>\n<h3>Water (2.5.12)<\/h3>\n<p>2.8 per cent to 4.2 per cent, determined on 0.300 g.<\/p>\n<h2>ASSAY<\/h2>\n<p>Liquid chromatography (2.2.29) as described in the test for related substances with the following modifications.<\/p>\n<p>Mobile phase: Mobile phase B, mobile phase A (30:70 V\/V).<\/p>\n<p>Injection: 10 \u03bcL of test solution (a) and reference solution (a).<\/p>\n<p>Run time: 3 times the retention time of benzylpenicillin.<\/p>\n<p>Calculate the percentage content of procaine (C<sub>13<\/sub>H<sub>20<\/sub>N<sub>2<\/sub>O<sub>2<\/sub>) taking into account the area of the peak due to procaine and the assigned content of procaine (C<sub>13<\/sub>H<sub>20<\/sub>N<sub>2<\/sub>O<sub>2<\/sub>) in procaine benzylpenicillin CRS.<\/p>\n<p>Calculate the percentage content of procaine benzylpenicillin (C<sub>29<\/sub>H<sub>38<\/sub>N<sub>4<\/sub>O<sub>6<\/sub>S) taking into account the area of the peak due to benzylpenicillin and the assigned content of procaine benzylpenicillin (C<sub>29<\/sub>H<sub>38<\/sub>N<sub>4<\/sub>O<sub>6<\/sub>S) in procaine benzylpenicillin CRS.<\/p>\n<h2>STORAGE<\/h2>\n<p>In an airtight container. If the substance is sterile, the container is also sterile and tamper-evident.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>Specified impurities A, B, C, D, E, F, G, H, I, J.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-4542\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/3-112-300x163.jpg\" alt=\"Benzylpenicillin (Procaine) Monohydrate\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/3-112-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/3-112-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/3-112-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/3-112.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>A. 4-aminobenzoic acid,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-4543\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/4-99-300x163.jpg\" alt=\"Benzylpenicillin (Procaine) Monohydrate\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/4-99-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/4-99-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/4-99-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/4-99.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>B. (2\u039e,4S)-2-[(\u039e)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid (penicilloic acids of benzylpenicillin),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-4544\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/5-87-300x163.jpg\" alt=\"Benzylpenicillin (Procaine) Monohydrate\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/5-87-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/5-87-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/5-87-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/5-87.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>C. (2RS,4S)-5,5-dimethyl-2-[(2-phenylacetamido)methyl]-1,3-thiazolidine-4-carboxylic acid (penilloic acids of benzylpenicillin),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-4545\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/6-73-300x163.jpg\" alt=\"Benzylpenicillin (Procaine) Monohydrate\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/6-73-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/6-73-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/6-73-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/6-73.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>D. (3S,7R,7aR)-5-benzyl-2,2-dimethyl-2,3,7,7a-tetrahydroimidazo[5,1-b][1,3]thiazole-3,7-dicarboxylic acid (penillic acid of benzylpenicillin),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-4546\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/7-59-300x163.jpg\" alt=\"Benzylpenicillin (Procaine) Monohydrate\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/7-59-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/7-59-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/7-59-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/7-59.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>E. phenylacetic acid,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-4547\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/8-49-300x163.jpg\" alt=\"Benzylpenicillin (Procaine) Monohydrate\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/8-49-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/8-49-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/8-49-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/8-49.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>F. (2S,5R,6R)-6-[2-(4-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2- carboxylic acid,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-4548\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/9-38-300x163.jpg\" alt=\"Benzylpenicillin (Procaine) Monohydrate\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/9-38-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/9-38-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/9-38-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/9-38.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>G. (2S,5R,6R)-6-[(3Z)-hex-3-enamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (iso-penicillin F),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-4549\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/10-29-300x163.jpg\" alt=\"Benzylpenicillin (Procaine) Monohydrate\" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/10-29-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/10-29-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/10-29-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/09\/10-29.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>H. (2S,5R,6R)-6-hexanamido-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (dihydropenicillin F),<\/p>\n<p>I. unknown structure,<\/p>\n<p>J. unknown structure.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 0115) C29H38N4O6S,H2O 588.7 6130-64-9 Action and use Penicillin antibacterial. Preparation Procaine Benzylpenicillin Injection DEFINITION 2-(Diethylamino)ethyl 4-aminobenzoate (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid monohydrate. Salt obtained from Benzylpenicillin sodium (0114) or Benzylpenicillin potassium (0113) produced by the growth of certain strains of Penicillium notatum or related micro-organisms. Content \u2014 procaine benzylpenicillin: 96.0 per cent to 102.0 per&#8230;<\/p>\n","protected":false},"author":4,"featured_media":4541,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-4154","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/4154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=4154"}],"version-history":[{"count":5,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/4154\/revisions"}],"predecessor-version":[{"id":7982,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/4154\/revisions\/7982"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/4541"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=4154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=4154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=4154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}