{"id":4107,"date":"2025-09-26T08:50:00","date_gmt":"2025-09-26T01:50:00","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=4107"},"modified":"2025-09-29T10:05:28","modified_gmt":"2025-09-29T03:05:28","slug":"benzyl-benzoate-application","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/benzyl-benzoate-application\/","title":{"rendered":"Benzyl Benzoate Application"},"content":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n

Benzyl Benzoate Cutaneous Emulsion<\/p>\n

DEFINITION<\/h2>\n

Benzyl Benzoate Application is a cutaneous emulsion. It contains 25% w\/v of Benzyl Benzoate in a suitable oil-in-water emulsified basis.<\/p>\n

Extemporaneous preparation<\/strong><\/p>\n

The following formula and directions apply.<\/p>\n

Benzyl Benzoate\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 250 g<\/p>\n

Emulsifying Wax\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a020 g<\/p>\n

Purified Water, freshly boiled and cooled\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Sufficient to produce 1000 mL<\/p>\n

Melt the Emulsifying Wax, add the Benzyl Benzoate and mix. Pour the mixture into sufficient warm Purified Water to produce 1000 mL and stir thoroughly until cold.<\/p>\n

The application complies with the requirements stated under Liquids for Cutaneous Application and with the following requirements.<\/p>\n

Content of benzyl benzoate, C14<\/sub>H12<\/sub>O2<\/sub><\/strong><\/p>\n

23.1 to 26.9% w\/v.<\/p>\n

ASSAY<\/h2>\n

Carry out the method for liquid chromatography, Appendix III D, using the following solutions.<\/p>\n

(1) Dissolve 1 g of the application in sufficient of the mobile phase to produce 100 mL and dilute 1 volume of the resulting solution to 50 volumes with the mobile phase.<\/p>\n

(2) 0.0050% w\/v of benzyl benzoate BPCRS in the mobile phase.<\/p>\n

CHROMATOGRAPHIC CONDITIONS<\/h3>\n

(a) Use a stainless steel column (20 cm \u00d7 4.6 mm) packed with end-capped octadecylsilyl silica gel for chromatography (10 \u03bcm) (Nucleosil C18 is suitable).<\/p>\n

(b) Use isocratic elution and the mobile phase described below.<\/p>\n

(c) Use a flow rate of 1.5 mL per minute.<\/p>\n

(d) Use an ambient column temperature.<\/p>\n

(e) Use a detection wavelength of 230 nm.<\/p>\n

(f) Inject 20 \u03bcL of each solution.<\/p>\n

MOBILE PHASE<\/h3>\n

30 volumes of water and 70 volumes of acetonitrile.<\/p>\n

DETERMINATION OF CONTENT<\/h3>\n

Determine the weight per mL of the application, Appendix V G, and calculate the content of C14<\/sub>H12<\/sub>O2<\/sub>, weight in volume, using the declared content of C14<\/sub>H12<\/sub>O2<\/sub> in benzyl benzoate BPCRS.<\/p>\n","protected":false},"excerpt":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update) Benzyl Benzoate Cutaneous Emulsion DEFINITION Benzyl Benzoate Application is a cutaneous emulsion. It contains 25% w\/v of Benzyl Benzoate in a suitable oil-in-water emulsified basis. Extemporaneous preparation The following formula and directions apply. Benzyl Benzoate\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0…<\/p>\n","protected":false},"author":5,"featured_media":4112,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[175],"tags":[],"class_list":["post-4107","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-formulated-preparations-specific-monographs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/4107","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=4107"}],"version-history":[{"count":4,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/4107\/revisions"}],"predecessor-version":[{"id":5124,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/4107\/revisions\/5124"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/4112"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=4107"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=4107"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=4107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}