{"id":4001,"date":"2025-09-25T14:36:00","date_gmt":"2025-09-25T07:36:00","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=4001"},"modified":"2025-10-03T09:06:43","modified_gmt":"2025-10-03T02:06:43","slug":"calcium-glycerophosphate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/calcium-glycerophosphate\/","title":{"rendered":"Calcium Glycerophosphate"},"content":{"rendered":"

(Ph. Eur. monograph 0980)<\/p>\n

C3<\/sub>H7<\/sub>CaO6<\/sub>P,xH2<\/sub>O\u00a0 \u00a0 \u00a0210.1 (anhydrous substance)<\/p>\n

Anhydrous calcium glycerophosphate 27214-00-2<\/p>\n

Action and use<\/strong><\/p>\n

Excipient.<\/p>\n

DEFINITION<\/h2>\n

Mixture in variable proportions of the calcium salt of (2RS)-2,3-dihydroxypropyl phosphate and of 1,3-dihydroxypropan-2-yl phosphate. It may be anhydrous or contain a variable quantity of water.<\/p>\n

Content<\/h3>\n

18.6 per cent to 19.4 per cent of Ca (dried substance).<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

White or almost white powder, hygroscopic.<\/p>\n

Solubility<\/h3>\n

Sparingly soluble in water, practically insoluble in ethanol (96 per cent).<\/p>\n

IDENTIFICATION<\/h3>\n

A. Mix 1 g with 1 g of potassium hydrogen sulfate R in a test tube fitted with a glass tube. Heat strongly and direct the white vapour towards a piece of filter paper impregnated with a freshly prepared 10 g\/L solution of sodium nitroprusside R. The filter paper develops a blue colour in contact with piperidine R.<\/p>\n

B. Ignite 0.1 g in a crucible. Take up the residue with 5 mL of nitric acid R and heat on a water-bath for 1 min. Filter. The filtrate gives reaction (b) of phosphates (2.3.1).<\/p>\n

C. It gives reaction (b) of calcium (2.3.1).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\n

Dissolve 1.5 g at room temperature in carbon dioxide-free water R prepared from distilled water R and dilute to 150 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\n

Solution S is not more opalescent than reference suspension III (2.2.1).<\/p>\n

Acidity or alkalinity<\/h3>\n

To 100 mL of solution S add 0.1 mL of phenolphthalein solution R. Not more than 1.5 mL of 0.1 M hydrochloric acid or 0.5 mL of 0.1 M sodium hydroxide is required to change the colour of the indicator.<\/p>\n

Citric acid<\/h4>\n

Shake 5.0 g with 20 mL of carbon dioxide-free water R and filter. To the filtrate add 0.15 mL of sulfuric acid R and filter again. To the filtrate add 5 mL of mercuric sulfate solution R and heat to boiling. Add 0.5 mL of a 3.2 g\/L solution of potassium permanganate R and again heat to boiling. No precipitate is formed.<\/p>\n

Glycerol and ethanol (96 per cent)-soluble substances<\/h3>\n

Maximum 0.5 per cent.<\/p>\n

Shake 1.000 g with 25 mL of ethanol (96 per cent) R for 1 min. Filter. Evaporate the filtrate on a water-bath and dry the residue at 70 \u00b0C for 1 h. The residue weighs a maximum of 5 mg.<\/p>\n

Chlorides (2.4.4)<\/h3>\n

Maximum 500 ppm.<\/p>\n

Dissolve 0.1 g in a mixture of 2 mL of acetic acid R and 8 mL of water R and dilute to 15 mL with water R.<\/p>\n

Phosphates (2.4.11)<\/h3>\n

Maximum 400 ppm.<\/p>\n

Dilute 2.5 mL of solution S to 100 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\n

Maximum 0.1 per cent, determined on solution S.<\/p>\n

Iron (2.4.9)<\/h3>\n

Maximum 50 ppm, determined on 0.20 g.<\/p>\n

Loss on drying (2.2.32)<\/h4>\n

Maximum 12.0 per cent, determined on 1.000 g by drying in an oven at 150 \u00b0C for 4 h.<\/p>\n

ASSAY<\/h2>\n

Dissolve 0.200 g in water R. Carry out the complexometric titration of calcium (2.5.11).<\/p>\n

1 mL of 0.1 M sodium edetate is equivalent to 4.008 mg of Ca.<\/p>\n","protected":false},"excerpt":{"rendered":"

(Ph. Eur. monograph 0980) C3H7CaO6P,xH2O\u00a0 \u00a0 \u00a0210.1 (anhydrous substance) Anhydrous calcium glycerophosphate 27214-00-2 Action and use Excipient. DEFINITION Mixture in variable proportions of the calcium salt of (2RS)-2,3-dihydroxypropyl phosphate and of 1,3-dihydroxypropan-2-yl phosphate. It may be anhydrous or contain a variable quantity of water. Content 18.6 per cent to 19.4 per cent of Ca (dried…<\/p>\n","protected":false},"author":3,"featured_media":4012,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-4001","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/4001","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=4001"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/4001\/revisions"}],"predecessor-version":[{"id":5603,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/4001\/revisions\/5603"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/4012"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=4001"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=4001"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=4001"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}