{"id":32052,"date":"2025-11-15T08:42:34","date_gmt":"2025-11-15T01:42:34","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=32052"},"modified":"2025-11-15T08:46:37","modified_gmt":"2025-11-15T01:46:37","slug":"tributyl-phosphate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/tributyl-phosphate\/","title":{"rendered":"Tributyl Phosphate"},"content":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n

(Tri-n-butyl Phosphate, Ph. Eur. monograph 1682)<\/p>\n

\"Tributyl<\/p>\n

C12<\/sub>H27<\/sub>O4<\/sub>P\u00a0 \u00a0 \u00a0 266.3\u00a0 \u00a0 \u00a0126-73-8<\/p>\n

Action and use<\/strong><\/p>\n

Excipient.<\/p>\n

Ph Eur<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

Clear, colourless or pale yellow liquid.<\/p>\n

Solubility<\/h3>\n

Slightly soluble in water, miscible with ethanol (96 per cent).<\/p>\n

bp<\/h3>\n

About 289 \u00b0C, with decomposition.<\/p>\n

IDENTIFICATION<\/h2>\n

Infrared absorption spectrophotometry (2.2.24).<\/p>\n

Comparison tri-n-butyl phosphate CRS.<\/p>\n

TESTS<\/h2>\n

Appearance<\/h3>\n

The substance to be examined is clear (2.2.1) and not more intensely coloured than reference solution Y6 (2.2.2, Method II).<\/p>\n

Acidity<\/h3>\n

Dissolve 50 mL in 50 mL of ethanol (96 per cent) R previously adjusted with 0.02 M potassium hydroxide or 0.02 M hydrochloric acid to a bluish-green colour, using 0.5 mL of bromothymol blue solution R1 as indicator. Titrate with 0.02 M potassium hydroxide to the initial bluish-green coloration. Not more than 0.8 mL of 0.02 M potassium hydroxide is required.<\/p>\n

Related substances<\/h3>\n

Gas chromatography (2.2.28): use the normalisation procedure.<\/p>\n

Test solution\u00a0 \u00a0The substance to be examined.<\/p>\n

Reference solution\u00a0 \u00a0Dissolve 10 mg of the substance to be examined and 10 mg of methyl myristate R in methylene chloride R and dilute to 10 mL with the same solvent.<\/p>\n

Column:<\/p>\n

\u2014 material: fused silica;<\/p>\n

\u2014 size: l = 30 m, \u00d8 = 0.32 mm;<\/p>\n

\u2014 stationary phase: methylpolysiloxane R (5 \u03bcm).<\/p>\n

Carrier gas\u00a0 \u00a0helium for chromatography R.<\/p>\n

Linear velocity\u00a0 \u00a032 cm\/s.<\/p>\n

Split ratio\u00a0 \u00a065:1.<\/p>\n

Temperature:<\/p>\n

\u2014 column: 250 \u00b0C;<\/p>\n

\u2014 injection port and detector: 250 \u00b0C.<\/p>\n

Detection\u00a0 \u00a0Flame ionisation.<\/p>\n

Injection\u00a0 \u00a01 \u03bcL.<\/p>\n

Run time\u00a0 \u00a0Twice the retention time of tri-n-butyl phosphate.<\/p>\n

System suitability\u00a0 \u00a0Reference solution:<\/p>\n

\u2014 resolution: minimum 10 between the peaks due to tri-n-butyl phosphate and methyl myristate.<\/p>\n

Limits:<\/p>\n

\u2014 any impurity: for each impurity, maximum 0.3 per cent;<\/p>\n

\u2014 total: maximum 0.5 per cent;<\/p>\n

\u2014 disregard limit: 0.01 per cent.<\/p>\n

Chlorides (2.4.4)<\/h3>\n

Maximum 200 ppm.<\/p>\n

Dissolve 0.25 g in 15 mL of ethanol (70 per cent V\/V) R. The solution complies with the test. Prepare the reference solution using 10 mL of chloride standard solution (5 ppm Cl) R and 5 mL of anhydrous ethanol R.<\/p>\n

Water (2.5.32)<\/h3>\n

Maximum 0.1 per cent, determined on 1.0 g.<\/p>\n

STORAGE<\/h2>\n

Protected from light.<\/p>\n

IMPURITIES<\/h2>\n

\"Tributyl<\/p>\n

A. dibutyl hydrogen phosphate,<\/p>\n

\"Tributyl<\/p>\n

B. butyl dihydrogen phosphate,<\/p>\n

C. H3<\/sub>C-[CH2<\/sub>]3<\/sub>-OH: butan-1-ol,<\/p>\n

\"Tributyl<\/p>\n

D. dibutyl methyl phosphate,<\/p>\n

\"Tributyl<\/p>\n

E. dibutyl ethyl phosphate,<\/p>\n

\"Tributyl<\/p>\n

F. dibutyl propyl phosphate,<\/p>\n

\"Tributyl<\/p>\n

G. dibutyl 2-methylpropyl phosphate,<\/p>\n

\"Tributyl<\/p>\n

H. dibutyl pentyl phosphate,<\/p>\n

\"Tributyl<\/p>\n

Ph Eur<\/p>\n","protected":false},"excerpt":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update) (Tri-n-butyl Phosphate, Ph. Eur. monograph 1682) C12H27O4P\u00a0 \u00a0 \u00a0 266.3\u00a0 \u00a0 \u00a0126-73-8 Action and use Excipient. Ph Eur CHARACTERS Appearance Clear, colourless or pale yellow liquid. Solubility Slightly soluble in water, miscible with ethanol (96 per cent). bp About 289 \u00b0C, with decomposition. IDENTIFICATION Infrared absorption spectrophotometry (2.2.24)….<\/p>\n","protected":false},"author":5,"featured_media":32053,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-32052","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/32052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=32052"}],"version-history":[{"count":4,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/32052\/revisions"}],"predecessor-version":[{"id":32073,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/32052\/revisions\/32073"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/32053"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=32052"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=32052"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=32052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}