{"id":31886,"date":"2025-11-14T16:38:51","date_gmt":"2025-11-14T09:38:51","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=31886"},"modified":"2025-11-14T16:38:51","modified_gmt":"2025-11-14T09:38:51","slug":"zinc-gluconate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/zinc-gluconate\/","title":{"rendered":"Zinc Gluconate"},"content":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n

DEFINITION<\/h2>\n

Zinc D-gluconate.<\/p>\n

Content<\/strong><\/p>\n

98.0 per cent to 102.0 per cent (anhydrous substance).<\/p>\n

It may be anhydrous or contain a variable quantity of water.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

White or almost white, hygroscopic, crystalline powder.<\/p>\n

Solubility<\/h3>\n

Soluble in water, practically insoluble in anhydrous ethanol and in methylene chloride.<\/p>\n

IDENTIFICATION<\/h2>\n

A. Thin-layer chromatography (2.2.27).<\/p>\n

Test solution\u00a0 Dissolve 20 mg of the substance to be examined in 1 mL of water R.<\/p>\n

Reference solution Dissolve 20 mg of calcium gluconate CRS in 1 mL of water R, heating if necessary in a water-bath at 60 \u00b0C.<\/p>\n

Plate\u00a0 TLC silica gel plate R (5-40 \u00b5m) [or TLC silica gel plate R (2-10 \u00b5m)].<\/p>\n

Mobile phase concentrated ammonia R, ethyl acetate R, water R, ethanol (96 per cent) R (10:10:30:50 V\/V\/V\/V). Application 1 \u00b5L.<\/p>\n

Development\u00a0 Over 3\/4 of the plate.<\/p>\n

Drying\u00a0 At 100-105 \u00b0C for 20 min, then allow to cool to room temperature.<\/p>\n

Detection Spray with a solution containing 25 g\/L of ammonium molybdate R and 10 g\/L of cerium sulfate R in dilute sulfuric acid R, and heat at 100-105 \u00b0C for about 10 min.<\/p>\n

Results The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution.<\/p>\n

B. Dissolve 0.1 g in 5 mL of water R. Add 0.5 mL of potassium ferrocyanide solution R. A white precipitate is formed that does not dissolve upon the addition of 5 mL of hydrochloric acid R.<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\n

Dissolve 0.50 g in water R and dilute to 25 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\n

Solution S is not more opalescent than reference suspension II (2.2.1) and not more intensely coloured than reference solution Y6 (2.2.2, Method II).<\/p>\n

Sucrose and reducing sugars<\/h3>\n

Dissolve 0.5 g in a mixture of 2 mL of hydrochloric acid R1 and 10 mL of water R. Boil for 5 min, allow to cool, add 10 mL of sodium carbonate solution R and allow to stand for 10 min. Dilute to 25 mL with water R and filter. To 5 mL of the filtrate add 2 mL of cupri-tartaric solution R and boil for 1 min. Allow to stand for 2 min. No red precipitate is formed.<\/p>\n

Chlorides (2.4.4)<\/strong><\/p>\n

Maximum 500 ppm.<\/p>\n

Dilute 5 mL of solution S to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/strong><\/p>\n

Maximum 500 ppm.<\/p>\n

Dissolve 2.0 g in a mixture of 10 mL of acetic acid R and 90 mL of distilled water R.<\/p>\n

Elemental impurities<\/h3>\n

Any method that fulfils the requirements of general chapter 2.4.20. Determination of elemental impurities may be used.<\/p>\n\n\n\n\n
Element<\/strong><\/td>\nMaximum content (ppm)<\/strong><\/td>\n<\/tr>\n
Cadmium<\/p>\n

Lead<\/p>\n

Thallium<\/td>\n

1<\/p>\n

2<\/p>\n

2<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Water (2.5.32)<\/strong><\/p>\n

Maximum 12.0 per cent, determined on 80.0 mg.<\/p>\n

ASSAY<\/h2>\n

Dissolve 0.400 g in 5 mL of dilute acetic acid R. Carry out the complexometric titration of zinc (2.5.11). 1 mL of 0.1 M sodium edetate is equivalent to 45.57 mg of C12<\/sub>H22<\/sub>ZnO14<\/sub>.<\/p>\n

STORAGE<\/h2>\n

In a non-metallic, airtight container.<\/p>\n","protected":false},"excerpt":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update) DEFINITION Zinc D-gluconate. Content 98.0 per cent to 102.0 per cent (anhydrous substance). It may be anhydrous or contain a variable quantity of water. CHARACTERS Appearance White or almost white, hygroscopic, crystalline powder. Solubility Soluble in water, practically insoluble in anhydrous ethanol and in methylene chloride. IDENTIFICATION A….<\/p>\n","protected":false},"author":5,"featured_media":31887,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-31886","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/31886","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=31886"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/31886\/revisions"}],"predecessor-version":[{"id":31893,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/31886\/revisions\/31893"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/31887"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=31886"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=31886"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=31886"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}