Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n
Action and use<\/strong><\/p>\n Astringent.<\/p>\n Preparation<\/strong><\/p>\n Erythromycin and Zinc Acetate Lotion Ph Eur<\/p>\n Content<\/strong><\/p>\n 99.0 per cent to 101.0 per cent of C4<\/sub>H6<\/sub>O4<\/sub>Zn,2H2<\/sub>O.<\/p>\n White or almost white crystalline powder or flakes.<\/p>\n Freely soluble in water, soluble in ethanol (96 per cent).<\/p>\n A. It gives reaction (b) of acetates (2.3.1).<\/p>\n B. It gives the reaction of zinc (2.3.1).<\/p>\n Dissolve 10.0 g in carbon dioxide-free water R prepared from distilled water R and dilute to 100 mL with the same solvent.<\/p>\n Solution S is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n pH (2.2.3)<\/strong><\/p>\n 5.8 to 7.0.<\/p>\n Dilute 10 mL of solution S to 20 mL with carbon dioxide-free water R.<\/p>\n Boil for 5 min a mixture of 10 mL of solution S, 90 mL of water R, 5 mL of dilute sulfuric acid R and 1.5 mL of a 0.3 g\/L solution of potassium permanganate R. The pink colour of the solution remains.<\/p>\n Chlorides (2.4.4)<\/strong><\/p>\n Maximum 50 ppm.<\/p>\n Dilute 10 mL of solution S to 15 mL with water R.<\/p>\n Sulfates (2.4.13)<\/strong><\/p>\n Maximum 100 ppm, determined on solution S.<\/p>\n Maximum 5 ppm.<\/p>\n Atomic absorption spectrometry (2.2.23, Method I).<\/p>\n Test solution Dissolve 2.50 g in 20 mL of a 200 g\/L solution of cadmium- and lead-free nitric acid R and dilute to 25.0 mL with the same acid solution.<\/p>\n Reference solutions Prepare the reference solutions using aluminium standard solution (200 ppm Al) R, diluting with a 200 g\/L solution of cadmium- and lead-free nitric acid R.<\/p>\n Source\u00a0 Aluminium hollow-cathode lamp.<\/p>\n Wavelength\u00a0 309.3 nm.<\/p>\n Atomisation device\u00a0 Air-acetylene or acetylene-nitrous oxide flame.<\/p>\n Maximum 1 ppm.<\/p>\n Atomic absorption spectrometry (2.2.23, Method I).<\/p>\n Test solution\u00a0 Use the solution described in the test for aluminium.<\/p>\n Reference solutions Prepare the reference solutions using cadmium standard solution (0.1 per cent Cd) R, diluting with a 200 g\/L solution of cadmium- and lead-free nitric acid R.<\/p>\n Source\u00a0 Cadmium hollow-cathode lamp.<\/p>\n Wavelength\u00a0 228.8 nm.<\/p>\n Atomisation device\u00a0 Air-acetylene flame.<\/p>\n Maximum 50 ppm.<\/p>\n Atomic absorption spectrometry (2.2.23, Method I).<\/p>\n Test solution Dissolve 1.25 g in 20 mL of a 200 g\/L solution of cadmium- and lead-free nitric acid R and dilute to 25.0 mL with the same acid solution.<\/p>\n Reference solutions Prepare the reference solutions using iron standard solution (20 ppm Fe) R, diluting with a 200 g\/L solution of cadmium- and lead-free nitric acid R.<\/p>\n Source\u00a0 Iron hollow-cathode lamp.<\/p>\n Wavelength\u00a0 248.3 nm.<\/p>\n Atomisation device\u00a0 Air-acetylene flame.<\/p>\n Maximum 1 ppm.<\/p>\n Atomic absorption spectrometry (2.2.23, Method I).<\/p>\n Test solution Dissolve 5.00 g in 20 mL of a 200 g\/L solution of cadmium- and lead-free nitric acid R and dilute to 25.0 mL with the same acid solution.<\/p>\n Reference solutions Prepare the reference solutions using lead standard solution (0.1 per cent Pb) R, diluting with a 200 g\/L solution of cadmium- and lead-free nitric acid R.<\/p>\n Source\u00a0 Lead hollow-cathode lamp.<\/p>\n Wavelength\u00a0 283.3 nm.<\/p>\n Atomisation device\u00a0 Air-acetylene flame.<\/p>\n Dissolve 0.200 g in 5 mL of dilute acetic acid R. Carry out the complexometric titration of zinc (2.5.11). 1 mL of 0.1 M sodium edetate is equivalent to 21.95 mg of C4<\/sub>H6<\/sub>O4<\/sub>Zn,2H2<\/sub>O.<\/p>\n In a non-metallic container.<\/p>\n","protected":false},"excerpt":{"rendered":" Edition: BP 2025 (Ph. Eur. 11.6 update) Action and use Astringent. Preparation Erythromycin and Zinc Acetate Lotion Ph Eur DEFINITION Content 99.0 per cent to 101.0 per cent of C4H6O4Zn,2H2O. CHARACTERS Appearance White or almost white crystalline powder or flakes. Solubility Freely soluble in water, soluble in ethanol (96 per cent). IDENTIFICATION A. It gives…<\/p>\n","protected":false},"author":5,"featured_media":31872,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-31871","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/31871","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=31871"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/31871\/revisions"}],"predecessor-version":[{"id":31875,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/31871\/revisions\/31875"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/31872"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=31871"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=31871"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=31871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}DEFINITION<\/h2>\n
CHARACTERS<\/h2>\n
Appearance<\/h3>\n
Solubility<\/h3>\n
IDENTIFICATION<\/h2>\n
TESTS<\/h2>\n
Solution S<\/h3>\n
Appearance of solution<\/h3>\n
Reducing substances<\/h3>\n
Aluminium<\/h3>\n
Cadmium<\/h3>\n
Iron<\/h3>\n
Lead<\/h3>\n
ASSAY<\/h2>\n
STORAGE<\/h2>\n