{"id":3038,"date":"2025-09-23T11:23:01","date_gmt":"2025-09-23T04:23:01","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=3038"},"modified":"2025-10-02T11:15:58","modified_gmt":"2025-10-02T04:15:58","slug":"ascorbyl-palmitate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/ascorbyl-palmitate\/","title":{"rendered":"Ascorbyl Palmitate"},"content":{"rendered":"

(Ph. Eur. monograph 0807)<\/em><\/p>\n

C_{22<\/sub>H_{38<\/sub>O_{7<\/sub>\u00a0 \u00a0 414.5\u00a0 \u00a0 137-66-6<\/p>\n}}}

Action and use<\/strong><\/p>\n

Excipient.<\/p>\n

DEFINITION<\/h2>\n
(2S)-2-[(2R)-3,4-Dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl hexadecanoate.<\/p>\n
Content<\/h3>\n
98.0 per cent to 100.5 per cent (dried substance).<\/p>\n
CHARACTERS<\/h2>\n
Appearance<\/h3>\n
White or yellowish-white powder.<\/p>\n
Solubility<\/h3>\n
Practically insoluble in water, freely soluble in ethanol (96 per cent) and in methanol, practically insoluble in methylene chloride and in fatty oils.<\/p>\n
IDENTIFICATION<\/h2>\n
A. Specific optical rotation (see Tests).<\/p>\n
B. Infrared absorption spectrophotometry (2.2.24).<\/p>\n
Comparison ascorbyl palmitate CRS.<\/p>\n
C. Dissolve about 10 mg in 5 mL of methanol R. The solution decolourises dichlorophenolindophenol standard solution R.<\/p>\n
TESTS<\/h2>\n
Solution S<\/h3>\n
Dissolve 2.50 g in methanol R using sonication and dilute to 25.0 mL with the same solvent.<\/p>\n
Appearance of solution<\/h3>\n
Solution S is clear (2.2.1) and not more intensely coloured than reference solution BY4 (2.2.2, Method I).<\/p>\n
Specific optical rotation (2.2.7)<\/h3>\n
+ 21 to + 24 (dried substance), determined on solution S.<\/p>\n
Related substances<\/h3>\n
The thresholds indicated under Related substances (Table 2034.-1) in the general monograph Substances for pharmaceutical use (2034) do not apply.<\/p>\n
Loss on drying (2.2.32)<\/h3>\n
Maximum 1.0 per cent, determined on 1.000 g by drying in vacuo at 60 \u00b0C for 5 h.<\/p>\n
Sulfated ash (2.4.14)<\/h3>\n
Maximum 0.1 per cent, determined on 1.0 g.<\/p>\n
ASSAY<\/h2>\n
Dissolve 0.200 g in 50 mL of ethanol (96 per cent) R. Add 30 mL of water R and titrate with 0.05 M iodine until a yellow colour is obtained.<\/p>\n
1 mL of 0.05 M iodine is equivalent to 20.73 mg of C22H38O7.<\/p>\n
STORAGE<\/h2>\n
In an airtight container, protected from light.<\/p>\n","protected":false},"excerpt":{"rendered":"
(Ph. Eur. monograph 0807) C22H38O7\u00a0 \u00a0 414.5\u00a0 \u00a0 137-66-6 Action and use Excipient. DEFINITION (2S)-2-[(2R)-3,4-Dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl hexadecanoate. Content 98.0 per cent to 100.5 per cent (dried substance). CHARACTERS Appearance White or yellowish-white powder. Solubility Practically insoluble in water, freely soluble in ethanol (96 per cent) and in methanol, practically insoluble in methylene chloride and in fatty…<\/p>\n","protected":false},"author":4,"featured_media":3047,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-3038","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/3038","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=3038"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/3038\/revisions"}],"predecessor-version":[{"id":5616,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/3038\/revisions\/5616"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/3047"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=3038"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=3038"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=3038"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Content<\/h3>\n98.0 per cent to 100.5 per cent (dried substance).<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\nWhite or yellowish-white powder.<\/p>\n

Solubility<\/h3>\nPractically insoluble in water, freely soluble in ethanol (96 per cent) and in methanol, practically insoluble in methylene chloride and in fatty oils.<\/p>\n

IDENTIFICATION<\/h2>\nA. Specific optical rotation (see Tests).<\/p>\nB. Infrared absorption spectrophotometry (2.2.24).<\/p>\nComparison ascorbyl palmitate CRS.<\/p>\nC. Dissolve about 10 mg in 5 mL of methanol R. The solution decolourises dichlorophenolindophenol standard solution R.<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\nDissolve 2.50 g in methanol R using sonication and dilute to 25.0 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\nSolution S is clear (2.2.1) and not more intensely coloured than reference solution BY4 (2.2.2, Method I).<\/p>\n

Specific optical rotation (2.2.7)<\/h3>\n+ 21 to + 24 (dried substance), determined on solution S.<\/p>\n

Related substances<\/h3>\nThe thresholds indicated under Related substances (Table 2034.-1) in the general monograph Substances for pharmaceutical use (2034) do not apply.<\/p>\n

Loss on drying (2.2.32)<\/h3>\nMaximum 1.0 per cent, determined on 1.000 g by drying in vacuo at 60 \u00b0C for 5 h.<\/p>\n

Sulfated ash (2.4.14)<\/h3>\nMaximum 0.1 per cent, determined on 1.0 g.<\/p>\n

ASSAY<\/h2>\nDissolve 0.200 g in 50 mL of ethanol (96 per cent) R. Add 30 mL of water R and titrate with 0.05 M iodine until a yellow colour is obtained.<\/p>\n1 mL of 0.05 M iodine is equivalent to 20.73 mg of C22H38O7.<\/p>\n

Content<\/h3>\n
98.0 per cent to 100.5 per cent (dried substance).<\/p>\n

Appearance<\/h3>\n
White or yellowish-white powder.<\/p>\n

Solubility<\/h3>\n
Practically insoluble in water, freely soluble in ethanol (96 per cent) and in methanol, practically insoluble in methylene chloride and in fatty oils.<\/p>\n

IDENTIFICATION<\/h2>\n
A. Specific optical rotation (see Tests).<\/p>\n
B. Infrared absorption spectrophotometry (2.2.24).<\/p>\n
Comparison ascorbyl palmitate CRS.<\/p>\n
C. Dissolve about 10 mg in 5 mL of methanol R. The solution decolourises dichlorophenolindophenol standard solution R.<\/p>\n

Solution S<\/h3>\n
Dissolve 2.50 g in methanol R using sonication and dilute to 25.0 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\n
Solution S is clear (2.2.1) and not more intensely coloured than reference solution BY4 (2.2.2, Method I).<\/p>\n

Specific optical rotation (2.2.7)<\/h3>\n
+ 21 to + 24 (dried substance), determined on solution S.<\/p>\n

Related substances<\/h3>\n
The thresholds indicated under Related substances (Table 2034.-1) in the general monograph Substances for pharmaceutical use (2034) do not apply.<\/p>\n

Loss on drying (2.2.32)<\/h3>\n
Maximum 1.0 per cent, determined on 1.000 g by drying in vacuo at 60 \u00b0C for 5 h.<\/p>\n

Sulfated ash (2.4.14)<\/h3>\n
Maximum 0.1 per cent, determined on 1.0 g.<\/p>\n

ASSAY<\/h2>\n
Dissolve 0.200 g in 50 mL of ethanol (96 per cent) R. Add 30 mL of water R and titrate with 0.05 M iodine until a yellow colour is obtained.<\/p>\n
1 mL of 0.05 M iodine is equivalent to 20.73 mg of C22H38O7.<\/p>\n