Sodium Polystyrene Sulphonate<\/p>\n
(Ph. Eur. monograph 1909)<\/em><\/p>\n Action and use<\/strong><\/p>\n Used in the treatment of hyperkalaemia.<\/p>\n Polystyrene sulfonate resin prepared in the sodium form.<\/p>\n Exchange capacity 2.8 mmol to 3.4 mmol of potassium per gram (dried substance).<\/p>\n 9.4 per cent to 11.0 per cent of Na (dried substance).<\/p>\n Almost white or light brown powder.<\/p>\n Practically insoluble in water, in ethanol (96 per cent) and in methylene chloride.<\/p>\n A. Infrared absorption spectrophotometry (2.2.24).<\/p>\n Preparation: Discs using finely ground substance.<\/p>\n Comparison: Ph. Eur. reference spectrum of sodium polystyrene sulfonate.<\/p>\n B. Suspend 0.1 g in water R, add 2 mL of a 150 g\/L solution of potassium carbonate R, and heat to boiling. Allow to cool and filter. To the filtrate add 4 mL of potassium pyroantimonate solution R and heat to boiling. Allow to cool in iced water and if necessary rub the inside of the test-tube with a glass rod. A dense white precipitate is formed.<\/p>\n Liquid chromatography (2.2.29).<\/p>\n Test solution: Shake 10.0 g of the substance to be examined with 10 mL of acetone R for 30 min, centrifuge and use the supernatant.<\/p>\n Reference solution: Dissolve 10 mg of styrene R in acetone R and dilute to 100 mL with the same solvent. Dilute 1 mL of this solution to 100 mL with acetone R.<\/p>\n Column:<\/p>\n \u2014 size: l = 0.25 m, \u00d8 = 4 mm;<\/p>\n \u2014 stationary phase: octadecylsilyl silica gel for chromatography R (5 \u03bcm).<\/p>\n Mobile phase: acetonitrile R, water R (1:1 V\/V).<\/p>\n Flow rate: 2 mL\/min.<\/p>\n Detection: Spectrophotometer at 254 nm.<\/p>\n Injection: 20 \u03bcL.<\/p>\n Limit:<\/p>\n \u2014 styrene: not more than the area of the principal peak in the chromatogram obtained with the reference solution (1 ppm).<\/p>\n Maximum 0.10 per cent.<\/p>\n Atomic emission spectrometry (2.2.22, Method I).<\/p>\n Test solution: To 1.10 g add 5 mL of hydrochloric acid R, heat to boiling, cool and add 10 mL of water R. Filter, wash the filter and residue with water R and dilute the filtrate and washing to 25.0 mL with water R.<\/p>\n Reference solutions: Prepare the reference solutions using calcium standard solution (400 ppm Ca) R, diluted as necessary with water R.<\/p>\n Wavelength: 422.7 nm.<\/p>\n Maximum 0.10 per cent.<\/p>\n Atomic emission spectrometry (2.2.22, Method I).<\/p>\n Test solution: To 1.10 g add 5 mL of hydrochloric acid R, heat to boiling, cool and add 10 mL of water R. Filter, wash the filter and residue with water R and dilute the filtrate and washings to 25.0 mL with water R.<\/p>\n Reference solutions: Prepare the reference solutions using potassium standard solution (100 ppm K) R, diluted as necessary with water R.<\/p>\n Wavelength 766.5 nm.<\/p>\n Maximum 7.0 per cent, determined on 1.000 g by drying in an oven at 105 \u00b0C.<\/p>\n Bile-tolerant gram-negative bacteria: acceptance criterion less than 10 CFU\/g.<\/p>\n Atomic emission spectrometry (2.2.22, Method I).<\/p>\n Test solution: In a platinum crucible moisten 0.90 g with a few drops of sulfuric acid R, ignite very gently and allow to cool.<\/p>\n Moisten with a few drops of sulfuric acid R again, ignite at 800 \u00b1 50 \u00b0C until a carbon-free ash is obtained and allow to cool.<\/p>\n Add 20 mL of water R to the crucible, warm gently on a water-bath until dissolution, cool, transfer quantitatively to a 100 mL graduated flask and dilute to 100.0 mL with water R. Dilute 5 mL of this solution to 1000.0 mL with water R.<\/p>\n Reference solutions: Prepare the reference solutions using sodium standard solution (200 ppm Na) R, diluted as necessary with water R.<\/p>\n Wavelength: 589 nm.<\/p>\n Atomic emission spectrometry (2.2.22, Method I).<\/p>\n Solution A: 9.533 g\/L solution of potassium chloride R.<\/p>\n Test solution: To 1.6 g of the substance to be examined in a dry 250 mL ground-glass-stoppered flask add 100 mL of solution A, stopper and shake for 15 min. Filter, discard the first 20 mL of the filtrate and dilute 4 mL of the filtrate to 1000 mL with water R.<\/p>\n Reference solutions: Prepare the reference solutions by diluting 0, 1, 2, 3 and 4 mL of solution A respectively and 4, 3, 2, 1 and 0 mL of a 7.63 g\/L solution of sodium chloride R to 1000 mL with water R.<\/p>\n Wavelength: 766.5 nm.<\/p>\n Prepare a calibration curve using the reference solutions and calculate the potassium exchange capacity of the substance to be examined in millimoles per gram taking the concentration of potassium in solution A as 128 mmoles of K per litre.<\/p>\n In an airtight container.<\/p>\n Specified impurities A.<\/p>\n A. styrene.<\/p>\n","protected":false},"excerpt":{"rendered":" Sodium Polystyrene Sulphonate (Ph. Eur. monograph 1909) Action and use Used in the treatment of hyperkalaemia. DEFINITION Polystyrene sulfonate resin prepared in the sodium form. Exchange capacity 2.8 mmol to 3.4 mmol of potassium per gram (dried substance). Content 9.4 per cent to 11.0 per cent of Na (dried substance). CHARACTERS Appearance Almost white or…<\/p>\n","protected":false},"author":4,"featured_media":30040,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-30015","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/30015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=30015"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/30015\/revisions"}],"predecessor-version":[{"id":30043,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/30015\/revisions\/30043"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/30040"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=30015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=30015"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=30015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}DEFINITION<\/h2>\n
Content<\/h3>\n
CHARACTERS<\/h2>\n
Appearance<\/h3>\n
Solubility<\/h3>\n
IDENTIFICATION<\/h2>\n
TESTS<\/h2>\n
Styrene<\/h3>\n
Calcium<\/h3>\n
Potassium<\/h3>\n
Loss on drying (2.2.32)<\/h3>\n
Microbial contamination (2.6.13)<\/h3>\n
ASSAY<\/h2>\n
Sodium<\/h3>\n
Exchange capacity<\/h3>\n
STORAGE<\/h2>\n
IMPURITIES<\/h2>\n