{"id":30001,"date":"2025-11-11T14:31:05","date_gmt":"2025-11-11T07:31:05","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=30001"},"modified":"2025-11-11T14:31:05","modified_gmt":"2025-11-11T07:31:05","slug":"sodium-caprylate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/sodium-caprylate\/","title":{"rendered":"Sodium Caprylate"},"content":{"rendered":"

Sodium Octanoate<\/p>\n

(Ph. Eur. monograph 1471)<\/p>\n

C8<\/sub>H15<\/sub>NaO2<\/sub>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0166.2\u00a0 \u00a0 \u00a0 \u00a0 \u00a01984-06-1<\/p>\n

Action and use<\/strong><\/p>\n

Excipient.<\/p>\n

DEFINITION<\/h2>\n

Sodium octanoate.<\/p>\n

Content<\/h3>\n

99.0 per cent to 101.0 per cent (anhydrous substance).<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

White or almost white, crystalline powder.<\/p>\n

Solubility<\/h3>\n

Very soluble or freely soluble in water, freely soluble in acetic acid, sparingly soluble in ethanol (96 per cent), practically insoluble in acetone.<\/p>\n

IDENTIFICATION<\/h2>\n

A. Examine the chromatograms obtained in the test for related substances.<\/p>\n

Results: The principal peak in the chromatogram obtained with the test solution is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution (a).<\/p>\n

B. To 0.2 mL of solution S (see Tests) add 0.3 mL of water R. The solution gives reaction (b) of sodium (2.3.1).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\n

Dissolve 2.5 g in carbon dioxide-free water R and dilute to 25 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\n

Solution S is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n

pH (2.2.3)<\/h4>\n

8.0 to 10.5 for solution S.<\/p>\n

Related substances<\/h3>\n

Gas chromatography (2.2.28): use the normalisation procedure.<\/p>\n

Test solution: Dissolve 0.116 g in water R and dilute to 5 mL with the same solvent. Add 1 mL of a 2.8 per cent V\/V solution of sulfuric acid R and shake with 10 mL of ethyl acetate R. Separate the organic layer and dry over anhydrous sodium sulfate R.<\/p>\n

Reference solution (a): Dissolve 0.10 g of caprylic acid CRS in ethyl acetate R and dilute to 10 mL with the same solvent.<\/p>\n

Reference solution (b): Dilute 1 mL of the test solution to 100 mL with ethyl acetate R. Dilute 5 mL of this solution to 50 mL with ethyl acetate R.<\/p>\n

Column:<\/p>\n

\u2014 material: fused silica;<\/p>\n

\u2014 size: l = 30 m, \u00d8 = 0.25 mm;<\/p>\n

\u2014 stationary phase: macrogol 20 000 2-nitroterephthalate R (film thickness 0.25 \u03bcm).<\/p>\n

Carrier gas: helium for chromatography R.<\/p>\n

Flow rate: 1.5 mL\/min.<\/p>\n

Split ratio: 1:100.<\/p>\n

Temperature:<\/p>\n\n\n\n\n\n\n\n\n
<\/td>\nTime<\/strong>
\n(min)<\/strong><\/td>\n		Temperature<\/strong>
\n(\u00b0C)<\/strong><\/td>\n<\/tr>\n
Column<\/td>\n0 – 1<\/td>\n100<\/td>\n<\/tr>\n
<\/td>\n1 – 25<\/td>\n100 \u2192 220<\/td>\n<\/tr>\n
<\/td>\n25 – 35<\/td>\n220<\/td>\n<\/tr>\n
Injection port<\/td>\n<\/td>\n250<\/td>\n<\/tr>\n
Detector<\/td>\n<\/td>\n250<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Detection: Flame ionisation.<\/p>\n

Injection: 1 \u03bcL.<\/p>\n

System suitability: Reference solution (b):<\/p>\n

\u2014 signal-to-noise ratio: minimum 5 for the principal peak.<\/p>\n

Limits:<\/p>\n

\u2014 any impurity: for each impurity, maximum 0.3 per cent;<\/p>\n

\u2014 total: maximum 0.5 per cent;<\/p>\n

\u2014 disregard limit: 0.5 times the area of the principal peak in the chromatogram obtained with reference solution (b) (0.05 per cent).<\/p>\n

Water (2.5.12)<\/h4>\n

Maximum 3.0 per cent, determined on 1.000 g.<\/p>\n

ASSAY<\/h2>\n

Dissolve 0.150 g in 50 mL of anhydrous acetic acid R. Titrate with 0.1 M perchloric acid, determining the end-point potentiometrically (2.2.20).<\/p>\n

1 mL of 0.1 M perchloric acid is equivalent to 16.62 mg of C8<\/sub>H15<\/sub>NaO2<\/sub>.<\/p>\n

IMPURITIES<\/h2>\n

\"Sodium<\/p>\n

A. hexanoic acid,<\/p>\n

\"Sodium<\/p>\n

B. heptanoic acid,<\/p>\n

\"Sodium<\/p>\n

C. nonanoic acid,<\/p>\n

\"Sodium<\/p>\n

D. decanoic acid,<\/p>\n

\"Sodium<\/p>\n

E. 2-propylpentanoic acid (valproic acid),<\/p>\n

\"Sodium<\/p>\n

F. methyl octanoate,<\/p>\n

\"Sodium<\/p>\n

G. ethyl octanoate,<\/p>\n

\"Sodium<\/p>\n

H. methyl decanoate,<\/p>\n

\"Sodium<\/p>\n

I. undecan-2-one,<\/p>\n

\"Sodium<\/p>\n

J. (RS)-5-butyltetrahydrofuran-2-one (\u03b3-hydroxyoctanoic acid lactone).S<\/p>\n","protected":false},"excerpt":{"rendered":"

Sodium Octanoate (Ph. Eur. monograph 1471) C8H15NaO2\u00a0 \u00a0 \u00a0 \u00a0 \u00a0166.2\u00a0 \u00a0 \u00a0 \u00a0 \u00a01984-06-1 Action and use Excipient. DEFINITION Sodium octanoate. Content 99.0 per cent to 101.0 per cent (anhydrous substance). CHARACTERS Appearance White or almost white, crystalline powder. Solubility Very soluble or freely soluble in water, freely soluble in acetic acid, sparingly soluble…<\/p>\n","protected":false},"author":2,"featured_media":30032,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-30001","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/30001","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=30001"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/30001\/revisions"}],"predecessor-version":[{"id":30035,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/30001\/revisions\/30035"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/30032"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=30001"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=30001"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=30001"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}