{"id":29954,"date":"2025-11-11T11:53:29","date_gmt":"2025-11-11T04:53:29","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=29954"},"modified":"2025-11-11T11:53:29","modified_gmt":"2025-11-11T04:53:29","slug":"sodium-bicarbonate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/sodium-bicarbonate\/","title":{"rendered":"Sodium Bicarbonate"},"content":{"rendered":"

(Sodium Hydrogen Carbonate, Ph. Eur. monograph 0195)<\/p>\n

NaHCO_{3<\/sub>\u00a0 \u00a0 \u00a0 \u00a0 84.0\u00a0 \u00a0 \u00a0 \u00a0144-55-8<\/p>\n}

Action and use<\/strong><\/p>\n

Antacid; used in treatment of electrolyte deficiency.<\/p>\n

Preparations<\/strong><\/p>\n

Sodium Bicarbonate Ear Drops<\/p>\n

Sodium Bicarbonate Eye Lotion<\/p>\n

Sodium Bicarbonate Infusion<\/p>\n

Sodium Bicarbonate Oral Solution<\/p>\n

Compound Sodium Bicarbonate Tablets<\/p>\n

DEFINITION<\/h2>\n
Content<\/h3>\n
99.0 per cent to 101.0 per cent.<\/p>\n
CHARACTERS<\/h2>\n
Appearance<\/h3>\n
White or almost white, crystalline powder.<\/p>\n
Solubility<\/h3>\n
Soluble in water, practically insoluble in ethanol (96 per cent).<\/p>\n
When heated in the dry state or in solution, it gradually changes into sodium carbonate.<\/p>\n
IDENTIFICATION<\/h2>\n
A. To 5 mL of solution S (see Tests) add 0.1 mL of phenolphthalein solution R. A pale pink colour is produced. Heat; gas is evolved and the solution becomes red.<\/p>\n
B. It gives the reaction of carbonates and bicarbonates (2.3.1).<\/p>\n
C. Solution S gives reaction (a) of sodium (2.3.1).<\/p>\n
TESTS<\/h2>\n
Solution S<\/h3>\n
Dissolve 5.0 g in 90 mL of carbon dioxide-free water R and dilute to 100.0 mL with the same solvent.<\/p>\n
Appearance of solution<\/h3>\n
Solution S is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n
Carbonates<\/h3>\n
The pH (2.2.3) of freshly prepared solution S is not greater than 8.6.<\/p>\n
Chlorides (2.4.4)<\/h3>\n
Maximum 150 ppm.<\/p>\n
To 7 mL of solution S add 2 mL of nitric acid R and dilute to 15 mL with water R.<\/p>\n
Sulfates (2.4.13)<\/h3>\n
Maximum 150 ppm.<\/p>\n
To a suspension of 1.0 g in 10 mL of distilled water R add hydrochloric acid R until neutral and about 1 mL in excess. Dilute to 15 mL with distilled water R.<\/p>\n
Ammonium (2.4.1)<\/h3>\n
Maximum 20 ppm.<\/p>\n
Dilute 10 mL of solution S to 15 mL with water R. Prepare the standard using a mixture of 5 mL of water R and 10 mL of ammonium standard solution (1 ppm NH4) R.<\/p>\n
Calcium (2.4.3)<\/h3>\n
Maximum 100 ppm.<\/p>\n
To a suspension of 1.0 g in 10 mL of distilled water R add hydrochloric acid R until neutral and dilute to 15 mL with distilled water R.<\/p>\n
Iron (2.4.9)<\/h3>\n
Maximum 20 ppm.<\/p>\n
Dissolve 0.5 g in 5 mL of dilute hydrochloric acid R and dilute to 10 mL with water R.<\/p>\n
ASSAY<\/h2>\n
Dissolve 0.750 g in 50 mL of carbon dioxide-free water R. Titrate with 1 M hydrochloric acid, determining the end-point potentiometrically (2.2.20). Read the volume added at the 2 point of inflection, or at the point of inflection if only 1 point is detected.<\/p>\n
1 mL of 1 M hydrochloric acid is equivalent to 84.0 mg of NaHCO_{3<\/sub>.<\/p>\n","protected":false},"excerpt":{"rendered":"}
(Sodium Hydrogen Carbonate, Ph. Eur. monograph 0195) NaHCO3\u00a0 \u00a0 \u00a0 \u00a0 84.0\u00a0 \u00a0 \u00a0 \u00a0144-55-8 Action and use Antacid; used in treatment of electrolyte deficiency. Preparations Sodium Bicarbonate Ear Drops Sodium Bicarbonate Eye Lotion Sodium Bicarbonate Infusion Sodium Bicarbonate Oral Solution Compound Sodium Bicarbonate Tablets DEFINITION Content 99.0 per cent to 101.0 per cent. CHARACTERS…<\/p>\n","protected":false},"author":2,"featured_media":29960,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-29954","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/29954","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=29954"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/29954\/revisions"}],"predecessor-version":[{"id":29962,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/29954\/revisions\/29962"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/29960"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=29954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=29954"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=29954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Content<\/h3>\n99.0 per cent to 101.0 per cent.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\nWhite or almost white, crystalline powder.<\/p>\n

Solubility<\/h3>\nSoluble in water, practically insoluble in ethanol (96 per cent).<\/p>\nWhen heated in the dry state or in solution, it gradually changes into sodium carbonate.<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\nDissolve 5.0 g in 90 mL of carbon dioxide-free water R and dilute to 100.0 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\nSolution S is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n

Carbonates<\/h3>\nThe pH (2.2.3) of freshly prepared solution S is not greater than 8.6.<\/p>\n

Chlorides (2.4.4)<\/h3>\nMaximum 150 ppm.<\/p>\nTo 7 mL of solution S add 2 mL of nitric acid R and dilute to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\nMaximum 150 ppm.<\/p>\nTo a suspension of 1.0 g in 10 mL of distilled water R add hydrochloric acid R until neutral and about 1 mL in excess. Dilute to 15 mL with distilled water R.<\/p>\n

Ammonium (2.4.1)<\/h3>\nMaximum 20 ppm.<\/p>\nDilute 10 mL of solution S to 15 mL with water R. Prepare the standard using a mixture of 5 mL of water R and 10 mL of ammonium standard solution (1 ppm NH4) R.<\/p>\n

Calcium (2.4.3)<\/h3>\nMaximum 100 ppm.<\/p>\nTo a suspension of 1.0 g in 10 mL of distilled water R add hydrochloric acid R until neutral and dilute to 15 mL with distilled water R.<\/p>\n

Iron (2.4.9)<\/h3>\nMaximum 20 ppm.<\/p>\nDissolve 0.5 g in 5 mL of dilute hydrochloric acid R and dilute to 10 mL with water R.<\/p>\n

Content<\/h3>\n
99.0 per cent to 101.0 per cent.<\/p>\n

Appearance<\/h3>\n
White or almost white, crystalline powder.<\/p>\n

Solubility<\/h3>\n
Soluble in water, practically insoluble in ethanol (96 per cent).<\/p>\n
When heated in the dry state or in solution, it gradually changes into sodium carbonate.<\/p>\n

Solution S<\/h3>\n
Dissolve 5.0 g in 90 mL of carbon dioxide-free water R and dilute to 100.0 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\n
Solution S is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n

Carbonates<\/h3>\n
The pH (2.2.3) of freshly prepared solution S is not greater than 8.6.<\/p>\n

Chlorides (2.4.4)<\/h3>\n
Maximum 150 ppm.<\/p>\n
To 7 mL of solution S add 2 mL of nitric acid R and dilute to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\n
Maximum 150 ppm.<\/p>\n
To a suspension of 1.0 g in 10 mL of distilled water R add hydrochloric acid R until neutral and about 1 mL in excess. Dilute to 15 mL with distilled water R.<\/p>\n

Ammonium (2.4.1)<\/h3>\n
Maximum 20 ppm.<\/p>\n
Dilute 10 mL of solution S to 15 mL with water R. Prepare the standard using a mixture of 5 mL of water R and 10 mL of ammonium standard solution (1 ppm NH4) R.<\/p>\n

Calcium (2.4.3)<\/h3>\n
Maximum 100 ppm.<\/p>\n
To a suspension of 1.0 g in 10 mL of distilled water R add hydrochloric acid R until neutral and dilute to 15 mL with distilled water R.<\/p>\n

Iron (2.4.9)<\/h3>\n
Maximum 20 ppm.<\/p>\n
Dissolve 0.5 g in 5 mL of dilute hydrochloric acid R and dilute to 10 mL with water R.<\/p>\n