{"id":29794,"date":"2025-11-11T09:55:20","date_gmt":"2025-11-11T02:55:20","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=29794"},"modified":"2025-11-11T09:55:20","modified_gmt":"2025-11-11T02:55:20","slug":"sodium-acetate-trihydrate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/sodium-acetate-trihydrate\/","title":{"rendered":"Sodium Acetate Trihydrate"},"content":{"rendered":"

(Ph. Eur. monograph 0411)<\/p>\n

C_{2<\/sub>H_{3<\/sub>NaO_{2<\/sub>,3H_{2<\/sub>O\u00a0 \u00a0 \u00a0 136.1\u00a0 \u00a0 \u00a0 \u00a06131-90-4<\/p>\n}}}}

Action and use<\/strong><\/p>\n

Used in solutions for dialysis; excipient.<\/p>\n

Preparation<\/strong><\/p>\n

Sodium Acetate Sterile Concentrate<\/p>\n

DEFINITION<\/h2>\n
Sodium acetate trihydrate (sodium ethanoate trihydrate).<\/p>\n
Content<\/h3>\n
99.0 per cent to 101.0 per cent (dried substance).<\/p>\n
CHARACTERS<\/h2>\n
Appearance<\/h3>\n
White or almost white, crystalline powder or colourless crystals.<\/p>\n
Solubility<\/h3>\n
Very soluble in water, soluble in ethanol (96 per cent).<\/p>\n
IDENTIFICATION<\/h2>\n
A. 1 mL of solution S (see Tests) gives reaction (b) of acetates (2.3.1).<\/p>\n
B. 1 mL of solution S gives reaction (a) of sodium (2.3.1).<\/p>\n
C. Loss on drying (see Tests).<\/p>\n
TESTS<\/h2>\n
Solution S<\/h3>\n
Dissolve 10.0 g in carbon dioxide-free water R prepared from distilled water R and dilute to 100 mL with the same solvent.<\/p>\n
Appearance of solution<\/h3>\n
Solution S is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n
pH (2.2.3)<\/h4>\n
7.5 to 9.0.<\/p>\n
Dilute 5 mL of solution S to 10 mL with carbon dioxide-free water R.<\/p>\n
Reducing substances<\/h3>\n
Dissolve 5.0 g in 50 mL of water R, then add 5 mL of dilute sulfuric acid R and 0.5 mL of a 0.32 g\/L solution of potassium permanganate R. The pink colour persists for at least 1 h. Prepare a blank in the same manner but without the substance to be examined.<\/p>\n
Chlorides (2.4.4)<\/h3>\n
Maximum 200 ppm.<\/p>\n
Dilute 2.5 mL of solution S to 15 mL with water R.<\/p>\n
Sulfates (2.4.13)<\/h3>\n
Maximum 200 ppm.<\/p>\n
Dilute 7.5 mL of solution S to 15 mL with distilled water R.<\/p>\n
Aluminium (2.4.17)<\/h3>\n
Maximum 0.2 ppm, if intended for use in the manufacture of dialysis solutions.<\/p>\n
Prescribed solution: Dissolve 20 g in 100 mL of water R and adjust to pH 6.0 with a 103 g\/L solution of hydrochloric acid R (about 10 mL).<\/p>\n
Reference solution: Mix 2 mL of aluminium standard solution (2 ppm Al) R, 10 mL of acetate buffer solution pH 6.0 R and 98 mL of water R.<\/p>\n
Blank solution: Mix 10 mL of acetate buffer solution pH 6.0 R and 100 mL of water R.<\/p>\n
Calcium and magnesium<\/h3>\n
Maximum 50 ppm, calculated as Ca.<\/p>\n
To 200 mL of water R add 10 mL of ammonium chloride buffer solution pH 10.0 R, 0.1 g of mordant black 11 triturate R, 2.0 mL of 0.05 M zinc chloride and, dropwise, 0.02 M sodium edetate until the colour changes from violet to blue. Add to the solution 10.0 g of the substance to be examined and shake to dissolve. Titrate with 0.02 M sodium edetate until the blue colour is restored. Not more than 0.65 mL of 0.02 M sodium edetate is required.<\/p>\n
Iron (2.4.9)<\/h3>\n
Maximum 10 ppm, determined on solution S.<\/p>\n
Loss on drying (2.2.32)<\/h4>\n
39.0 per cent to 40.5 per cent, determined on 1.000 g by drying in an oven at 130 \u00b0C. Introduce the substance to be examined into the oven while the latter is cold.<\/p>\n
ASSAY<\/h2>\n
Dissolve 0.250 g in 50 mL of anhydrous acetic acid R, add 5 mL of acetic anhydride R, mix and allow to stand for 30 min. Using 0.3 mL of naphtholbenzein solution R as indicator, titrate with 0.1 M perchloric acid until a green colour is obtained.<\/p>\n
1 mL of 0.1 M perchloric acid is equivalent to 8.20 mg of C_{2<\/sub>H_{3<\/sub>NaO_{2<\/sub>.<\/p>\n}}}
STORAGE<\/h2>\n
In an airtight container.<\/p>\n
LABELLING<\/h2>\n
The label states, where applicable, that the substance is suitable for use in the manufacture of dialysis solutions.<\/p>\n","protected":false},"excerpt":{"rendered":"
(Ph. Eur. monograph 0411) C2H3NaO2,3H2O\u00a0 \u00a0 \u00a0 136.1\u00a0 \u00a0 \u00a0 \u00a06131-90-4 Action and use Used in solutions for dialysis; excipient. Preparation Sodium Acetate Sterile Concentrate DEFINITION Sodium acetate trihydrate (sodium ethanoate trihydrate). Content 99.0 per cent to 101.0 per cent (dried substance). CHARACTERS Appearance White or almost white, crystalline powder or colourless crystals. Solubility Very…<\/p>\n","protected":false},"author":2,"featured_media":29801,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-29794","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/29794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=29794"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/29794\/revisions"}],"predecessor-version":[{"id":29803,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/29794\/revisions\/29803"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/29801"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=29794"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=29794"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=29794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Content<\/h3>\n99.0 per cent to 101.0 per cent (dried substance).<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\nWhite or almost white, crystalline powder or colourless crystals.<\/p>\n

Solubility<\/h3>\nVery soluble in water, soluble in ethanol (96 per cent).<\/p>\n

IDENTIFICATION<\/h2>\nA. 1 mL of solution S (see Tests) gives reaction (b) of acetates (2.3.1).<\/p>\nB. 1 mL of solution S gives reaction (a) of sodium (2.3.1).<\/p>\nC. Loss on drying (see Tests).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\nDissolve 10.0 g in carbon dioxide-free water R prepared from distilled water R and dilute to 100 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\nSolution S is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n

pH (2.2.3)<\/h4>\n7.5 to 9.0.<\/p>\nDilute 5 mL of solution S to 10 mL with carbon dioxide-free water R.<\/p>\n

Reducing substances<\/h3>\nDissolve 5.0 g in 50 mL of water R, then add 5 mL of dilute sulfuric acid R and 0.5 mL of a 0.32 g\/L solution of potassium permanganate R. The pink colour persists for at least 1 h. Prepare a blank in the same manner but without the substance to be examined.<\/p>\n

Chlorides (2.4.4)<\/h3>\nMaximum 200 ppm.<\/p>\nDilute 2.5 mL of solution S to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\nMaximum 200 ppm.<\/p>\nDilute 7.5 mL of solution S to 15 mL with distilled water R.<\/p>\n

Iron (2.4.9)<\/h3>\nMaximum 10 ppm, determined on solution S.<\/p>\n

Loss on drying (2.2.32)<\/h4>\n39.0 per cent to 40.5 per cent, determined on 1.000 g by drying in an oven at 130 \u00b0C. Introduce the substance to be examined into the oven while the latter is cold.<\/p>\n

STORAGE<\/h2>\nIn an airtight container.<\/p>\n

Content<\/h3>\n
99.0 per cent to 101.0 per cent (dried substance).<\/p>\n

Appearance<\/h3>\n
White or almost white, crystalline powder or colourless crystals.<\/p>\n

Solubility<\/h3>\n
Very soluble in water, soluble in ethanol (96 per cent).<\/p>\n

IDENTIFICATION<\/h2>\n
A. 1 mL of solution S (see Tests) gives reaction (b) of acetates (2.3.1).<\/p>\n
B. 1 mL of solution S gives reaction (a) of sodium (2.3.1).<\/p>\n
C. Loss on drying (see Tests).<\/p>\n

Solution S<\/h3>\n
Dissolve 10.0 g in carbon dioxide-free water R prepared from distilled water R and dilute to 100 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\n
Solution S is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n

pH (2.2.3)<\/h4>\n
7.5 to 9.0.<\/p>\n
Dilute 5 mL of solution S to 10 mL with carbon dioxide-free water R.<\/p>\n

Reducing substances<\/h3>\n
Dissolve 5.0 g in 50 mL of water R, then add 5 mL of dilute sulfuric acid R and 0.5 mL of a 0.32 g\/L solution of potassium permanganate R. The pink colour persists for at least 1 h. Prepare a blank in the same manner but without the substance to be examined.<\/p>\n

Chlorides (2.4.4)<\/h3>\n
Maximum 200 ppm.<\/p>\n
Dilute 2.5 mL of solution S to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\n
Maximum 200 ppm.<\/p>\n
Dilute 7.5 mL of solution S to 15 mL with distilled water R.<\/p>\n

Iron (2.4.9)<\/h3>\n
Maximum 10 ppm, determined on solution S.<\/p>\n

Loss on drying (2.2.32)<\/h4>\n
39.0 per cent to 40.5 per cent, determined on 1.000 g by drying in an oven at 130 \u00b0C. Introduce the substance to be examined into the oven while the latter is cold.<\/p>\n

STORAGE<\/h2>\n
In an airtight container.<\/p>\n