{"id":2978,"date":"2025-09-22T23:12:03","date_gmt":"2025-09-22T16:12:03","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=2978"},"modified":"2025-10-01T14:31:06","modified_gmt":"2025-10-01T07:31:06","slug":"acebutolol-tablets","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/acebutolol-tablets\/","title":{"rendered":"Acebutolol Tablets"},"content":{"rendered":"

BP 2025 (Ph. Eur. Update 11.6)<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

Action and use<\/span><\/span><\/span><\/span><\/span><\/span><\/strong><\/p>\n

Beta-adrenergic specific antibiotic.<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

DEFINITION<\/span><\/span><\/span><\/span><\/span><\/span><\/h2>\n
Acebutolol tablets contain Acebutolol Hydrochloride.<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n
These medicinal products comply with the requirements stated in the medicinal product and the following requirements.<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n
Acebutolol content, C <\/span><\/span><\/span><\/span><\/span><\/span>_{18<\/span><\/span><\/span><\/span><\/span><\/span><\/sub> H <\/span><\/span><\/span><\/span><\/span><\/span>_{28<\/span><\/span><\/span><\/span><\/span><\/span><\/sub> N <\/span><\/span><\/span><\/span><\/span><\/span>_{2<\/span><\/span><\/span><\/span><\/span><\/span><\/sub> O <\/span><\/span><\/span><\/span><\/span><\/span>_{4<\/span><\/span><\/span><\/span><\/span><\/span><\/sub><\/p>\n}}}}
95.0 to 105.0% of the stated amount.<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n
IDENTIFICATION<\/span><\/span><\/span><\/span><\/span><\/span><\/h2>\n
The infrared absorption spectrum of a 0.7% w\/w dispersion of the powdered tablets in potassium bromide, Annex II A, was consistent with the common reference of acebutolol hydrochloride (RS 380).<\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n
TESTS<\/h2>\n
Related substances<\/h3>\n
Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions in a solvent mixture of equal volumes of chloroform and methanol.<\/p>\n
(1) A quantity of the powdered tablets containing the equivalent of 0.4 g of Acebutolol in 20 mL of the solvent mixture, shaken for 2 minutes and centrifuged. Use the supernatant liquid.
\n(2) Dilute 3 volumes of solution (1) to 100 volumes with the solvent mixture. Further dilute 1 volume of the resulting solution to 10 volumes with the solvent mixture.
\n(3) Dilute 1 volume of solution (1) to 100 volumes with the solvent mixture. Further dilute 1 volume of the resulting solution to 10 volumes with the solvent mixture.<\/p>\n
CHROMATOGRAPHIC CONDITIONS<\/h3>\n
(a) Use a precoated silica gel F254 plate (Merck silica gel 60 F254 plates are suitable).
\n(b) Use the mobile phase as described below.
\n(c) Apply 10 \u03bcL of each solution.
\n(d) Develop the plate to 15 cm.
\n(e) After removal of the plate, allow it to dry in air and examine under ultraviolet light (254 nm).<\/p>\n
MOBILE PHASE<\/h3>\n
20 volumes of glacial acetic acid, 20 volumes of dimethylformamide and 60 volumes of chloroform.<\/p>\n
LIMITS<\/h3>\n
In the chromatogram obtained with solution (1):<\/p>\n
any secondary spot is not more intense than the spot in the chromatogram obtained with solution (2) (0.3%);<\/p>\n
not more than two such spots are more intense than the spot in the chromatogram obtained with solution (3) (0.1%).<\/p>\n
Disregard any spot remaining on the line of application.<\/p>\n
ASSAY<\/h2>\n
Shake a number of whole tablets containing the equivalent of 4 g of Acebutolol with 250 mL of water until completely
\ndisintegrated, add sufficient water to produce 1000 mL, filter and dilute 10 mL of the filtrate to 250 mL with water. To 10 mL
\nof this solution add 20 mL of 0.1M hydrochloric acid and sufficient water to produce 200 mL. Measure the absorbance of
\nthis solution, Appendix II B, at the maximum at 233 nm and calculate the content of C_{18<\/sub>H_{28<\/sub>N_{2<\/sub>O_{4<\/sub> in the tablets taking 643 as the value of A (1%, 1 cm) at the maximum at 233 nm.<\/p>\n}}}}
LABELLING<\/h2>\n
The quantity of active ingredient is stated in terms of the equivalent amount of Acebutolol.<\/p>\n","protected":false},"excerpt":{"rendered":"
BP 2025 (Ph. Eur. Update 11.6) Action and use Beta-adrenergic specific antibiotic. DEFINITION Acebutolol tablets contain Acebutolol Hydrochloride. These medicinal products comply with the requirements stated in the medicinal product and the following requirements. Acebutolol content, C 18 H 28 N 2 O 4 95.0 to 105.0% of the stated amount. IDENTIFICATION The infrared absorption…<\/p>\n","protected":false},"author":5,"featured_media":2979,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[175],"tags":[],"class_list":["post-2978","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-formulated-preparations-specific-monographs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/2978","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=2978"}],"version-history":[{"count":5,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/2978\/revisions"}],"predecessor-version":[{"id":5782,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/2978\/revisions\/5782"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/2979"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=2978"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=2978"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=2978"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

TESTS<\/h2>\n

MOBILE PHASE<\/h3>\n20 volumes of glacial acetic acid, 20 volumes of dimethylformamide and 60 volumes of chloroform.<\/p>\n

MOBILE PHASE<\/h3>\n
20 volumes of glacial acetic acid, 20 volumes of dimethylformamide and 60 volumes of chloroform.<\/p>\n