{"id":29516,"date":"2025-11-10T17:04:40","date_gmt":"2025-11-10T10:04:40","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=29516"},"modified":"2025-11-10T17:04:40","modified_gmt":"2025-11-10T10:04:40","slug":"simeticone-for-oral-use","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/simeticone-for-oral-use\/","title":{"rendered":"Simeticone for Oral Use"},"content":{"rendered":"

Action and use<\/strong><\/p>\n

Silicon dioxide analogue; defoaming agent.<\/p>\n

Preparations<\/strong><\/p>\n

Simeticone Suspension for Infants<\/p>\n

When activated dimethicone is prescribed or demanded, Simeticone for Oral Use shall be dispensed or supplied.<\/p>\n

DEFINITION<\/h2>\n

Simeticone for Oral Use contains not less than 4.5% and not more than 8.0% w\/w of silica, SiO2<\/sub>, and not less than 91.0% and not more than 97.0% w\/w of Dimeticone 1000. It is prepared by the addition of finely powdered silica to Dimeticone 1000.<\/p>\n

CHARACTERISTICS<\/h2>\n

A viscous, grey, translucent liquid.<\/p>\n

Immiscible with water and with ethanol (96%); almost completely soluble in toluene, leaving a residue of silica.<\/p>\n

IDENTIFICATION<\/h2>\n

A. The infrared absorption spectrum of the supernatant liquid obtained by centrifugation, Appendix II A, is concordant with the reference spectrum of dimeticone (RS 381).<\/p>\n

B. Ignite; dense white fumes are evolved leaving a white residue which is insoluble in hydrochloric acid.<\/p>\n

TESTS<\/h2>\n

Acidity<\/h3>\n

Dissolve 15.0 g in a mixture of 15 mL of toluene and 15 mL of butan-1-ol, previously neutralised to a 0.5% w\/v solution of bromophenol blue in ethanol (96%), and titrate with 0.1M ethanolic potassium hydroxide VS using the bromophenol blue solution as indicator. Not more than 0.15 mL is required to change the colour of the solution.<\/p>\n

Refractive index<\/h4>\n

Of the supernatant liquid obtained in Identification test A, 1.4050 to 1.4080, Appendix V E.<\/p>\n

Viscosity<\/h4>\n

Of the supernatant liquid obtained in Identification test A, 950 to 1050 mm2<\/sup>s-1<\/sup> , Appendix V H, Method I, using a U-tube viscometer (size G).<\/p>\n

Weight per mL<\/h4>\n

Of the supernatant liquid obtained in Identification test A, 0.965 to 0.980 g, Appendix V G.<\/p>\n

ASSAY<\/h2>\n

For silica<\/h3>\n

To 1 g add 50 mL of toluene, mix well and filter through an ignited silica crucible. Wash the residue thoroughly with toluene, dry at 105\u00b0 and ignite to constant weight at 500\u00b0.<\/p>\n

For dimeticone<\/h3>\n

Place 40 mg in a stoppered centrifuge tube, add 20 mL of toluene and shake for 20 minutes. Filter and record the infrared absorption spectrum, Appendix II A, of a 0.5-mm layer of the filtrate over the range 1330 to 1180 cm-1<\/sup> (7.52 to 8.47 \u03bcm).<\/p>\n

Measure the absorbance of the CH3<\/sub>Si stretching band at the maximum at 1261 cm (7.93 \u03bcm). Repeat the operation using dimeticone EPCRS in place of the preparation being examined.<\/p>\n","protected":false},"excerpt":{"rendered":"

Action and use Silicon dioxide analogue; defoaming agent. Preparations Simeticone Suspension for Infants When activated dimethicone is prescribed or demanded, Simeticone for Oral Use shall be dispensed or supplied. DEFINITION Simeticone for Oral Use contains not less than 4.5% and not more than 8.0% w\/w of silica, SiO2, and not less than 91.0% and not…<\/p>\n","protected":false},"author":2,"featured_media":29527,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-29516","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/29516","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=29516"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/29516\/revisions"}],"predecessor-version":[{"id":29529,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/29516\/revisions\/29529"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/29527"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=29516"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=29516"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=29516"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}