{"id":28975,"date":"2025-11-10T19:14:59","date_gmt":"2025-11-10T12:14:59","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=28975"},"modified":"2025-11-10T19:14:59","modified_gmt":"2025-11-10T12:14:59","slug":"proxymetacaine-hydrochloride","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/proxymetacaine-hydrochloride\/","title":{"rendered":"Proxymetacaine Hydrochloride"},"content":{"rendered":"<p>C<sub>16<\/sub>H<sub>26<\/sub>N<sub>2<\/sub>O<sub>3<\/sub>HCl\u00a0 \u00a0 \u00a0 \u00a0 330.9\u00a0 \u00a0 \u00a0 \u00a0 \u00a05875-06-9<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Local anaesthetic.<\/p>\n<p><strong>Preparation<\/strong><\/p>\n<p>Proxymetacaine Eye Drops<\/p>\n<h2>DEFINITION<\/h2>\n<p>Proxymetacaine Hydrochloride is 2-diethylaminoethyl 3-amino-4-propoxybenzoate hydrochloride. It contains not less than 98.0% and not more than 102.0% of C16H26N2O3,HCl, calculated with reference to the dried substance.<\/p>\n<h2>CHARACTERISTICS<\/h2>\n<p>A white or almost white, crystalline powder.<\/p>\n<p>Soluble in water; very soluble in absolute ethanol; practically insoluble in ether.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. The light absorption, Appendix II B, in the range 220 to 350 nm of a 0.002% w\/v solution exhibits three maxima, at 231, 268 and 310 nm. The absorbances at the maxima at 268 nm and at 310 nm are about 0.58 and about 0.32, respectively.<\/p>\n<p>B. The infrared absorption spectrum, Appendix II A, is concordant with the reference spectrum of proxymetacaine hydrochloride (RS 303).<\/p>\n<p>C. A 5% w\/v solution yields the reaction characteristic of primary aromatic amines and the reactions characteristic of chlorides, Appendix VI.<\/p>\n<h2>TESTS<\/h2>\n<h3>Acidity<\/h3>\n<p>pH of a 1% w\/v solution, 5.7 to 6.4, Appendix V L.<\/p>\n<h3>Related substances<\/h3>\n<p>A. Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions of the substance being examined in methanol.<\/p>\n<p>(1) 2.0% w\/v of the substance being examined.<\/p>\n<p>(2) 0.020% w\/v of the substance being examined.<\/p>\n<p>(3) 0.010% w\/v of the substance being examined.<\/p>\n<p>CHROMATOGRAPHIC CONDITIONS<\/p>\n<p>(a) Use as the coating silica gel GF254.<\/p>\n<p>(b) Use the mobile phase as described below.<\/p>\n<p>(c) Apply 10 \u03bcL of each solution.<\/p>\n<p>(d) Develop the plate to 15 cm.<\/p>\n<p>(e) After removal of the plate, dry in air, heat at 105\u00b0 for 10 minutes, allow to cool and examine under ultraviolet light (254 nm).<\/p>\n<p>MOBILE PHASE<\/p>\n<p>5 volumes of diethylamine, 30 volumes of ethyl acetate and 75 volumes of toluene.<\/p>\n<p>LIMITS<\/p>\n<p>Any secondary spot in the chromatogram obtained with solution (1);<\/p>\n<p>is not more intense than the spot in the chromatogram obtained with solution (2) (1%);<\/p>\n<p>not more than one such spot is more intense than the spot in the chromatogram obtained with solution (3) (0.5%).<\/p>\n<p>Disregard any spot remaining on the line of application.<\/p>\n<p>B. Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions in methanol.<\/p>\n<p>(1) 2.0% w\/v of the substance being examined.<\/p>\n<p>(2) 0.0050% w\/v of 3-amino-4-propoxybenzoic acid BPCRS.<\/p>\n<p>CHROMATOGRAPHIC CONDITIONS<\/p>\n<p>(a) Use as the coating silica gel GF254.<\/p>\n<p>(b) Use the mobile phase as described below.<\/p>\n<p>(c) Apply 10 \u03bcL of each solution.<\/p>\n<p>(d) Develop the plate to 15 cm.<\/p>\n<p>(e) After removal of the plate, dry in air, examine under ultraviolet light (254 nm).<\/p>\n<p>MOBILE PHASE<\/p>\n<p>4 volumes of glacial acetic acid, 20 volumes of cyclohexane and 80 volumes of 1,4-dioxan.<\/p>\n<p>LIMITS<\/p>\n<p>Any secondary spot in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (2) (0.25%). The principal spot remains on or near the line of application.<\/p>\n<h4>Loss on drying<\/h4>\n<p>When dried at 105\u00b0 for 3 hours, loses not more than 0.5% of its weight. Use 1 g.<\/p>\n<h4>Sulfated ash<\/h4>\n<p>Not more than 0.15%, Appendix IX A.<\/p>\n<h2>ASSAY<\/h2>\n<p>Carry out Method I for non-aqueous titration, Appendix VIII A, using 0.25 g, 20 mL of mercury(II) acetate solution and 1-naphtholbenzein solution as indicator. Each mL of 0.1M perchloric acid VS is equivalent to 16.54 mg of C<sub>16<\/sub>H<sub>26<\/sub>N<sub>2<\/sub>O<sub>3,<\/sub>HCl.<\/p>\n<h2>STORAGE<\/h2>\n<p>Proxymetacaine Hydrochloride should be protected from light.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>C16H26N2O3HCl\u00a0 \u00a0 \u00a0 \u00a0 330.9\u00a0 \u00a0 \u00a0 \u00a0 \u00a05875-06-9 Action and use Local anaesthetic. Preparation Proxymetacaine Eye Drops DEFINITION Proxymetacaine Hydrochloride is 2-diethylaminoethyl 3-amino-4-propoxybenzoate hydrochloride. It contains not less than 98.0% and not more than 102.0% of C16H26N2O3,HCl, calculated with reference to the dried substance. CHARACTERISTICS A white or almost white, crystalline powder. Soluble in&#8230;<\/p>\n","protected":false},"author":2,"featured_media":29664,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174,1],"tags":[],"class_list":["post-28975","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances","category-volumes-1-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28975","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=28975"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28975\/revisions"}],"predecessor-version":[{"id":29666,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28975\/revisions\/29666"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/29664"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=28975"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=28975"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=28975"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}