Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n
Action and use <\/strong><\/p>\n Counter-irritant.<\/p>\n Preparations<\/strong><\/p>\n Camphorated Opium Tincture<\/p>\n Concentrated Camphorated Opium Tincture Concentrated Camphor Water<\/p>\n (1RS,4RS)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one.<\/p>\n White or almost white, crystalline powder or friable, crystalline masses, highly volatile even at room temperature.<\/p>\n Slightly soluble in water, very soluble in ethanol (96 per cent) and in light petroleum, freely soluble in fatty oils, very slightly soluble in glycerol.<\/p>\n First identification: A, C.<\/em><\/p>\n Second identification: A, B, D.<\/em><\/p>\n A. Optical rotation (see Tests).<\/p>\n B. Melting point (2.2.14): 172 \u00b0C to 180 \u00b0C.<\/p>\n C. Infrared absorption spectrophotometry (2.2.24).<\/p>\n Preparation Mulls in liquid paraffin R. Comparison racemic camphor CRS.<\/p>\n D. Dissolve 1.0 g in 30 mL of methanol R. Add 1.0 g of hydroxylamine hydrochloride R and 1.0 g of anhydrous sodium acetate R. Boil under a reflux condenser for 2 h. Allow to cool and add 100 mL of water R. A precipitate is formed. Filter, wash with 10 mL of water R and recrystallise from 10 mL of a mixture of 4 volumes of ethanol (96 per cent) R and 6 volumes of water R. The crystals, dried in vacuo, melt (2.2.14) at 118 \u00b0C to 121 \u00b0C.<\/p>\n Carry out the weighings rapidly.<\/p>\n Dissolve 2.50 g in 10 mL of ethanol (96 per cent) R and dilute to 25.0 mL with the same solvent.<\/p>\n Solution S is clear (2.2.1) and colourless (2.2.2, Method II).<\/p>\n Dissolve 1.0 g in 10 mL of ethanol (96 per cent) R and add 0.1 mL of phenolphthalein solution R1. The solution is colourless. Not more than 0.2 mL of 0.1 M sodium hydroxide is required to change the colour of the indicator.<\/p>\n Optical rotation (2.2.7)<\/strong><\/p>\n -0.15\u00b0 to + 0.15\u00b0, determined on solution S.<\/p>\n Gas chromatography (2.2.28).<\/p>\n Test solution\u00a0 Dissolve 50 mg of the substance to be examined in hexane R and dilute to 50.0 mL with the same solvent.<\/p>\n Reference solution (a) Dissolve 50 mg of the substance to be examined and 50 mg of bornyl acetate R in hexane R and dilute to 50.0 mL with the same solvent.<\/p>\n Reference solution (b) Dilute 1.0 mL of the test solution to 200.0 mL with hexane R. Column:<\/p>\n \u2014 size: l = 2 m, \u00d8 = 2 mm;<\/p>\n \u2014 stationary phase: diatomaceous earth for gas chromatography R impregnated with 10 per cent m\/m of macrogol 20 000 R.<\/p>\n Carrier gas nitrogen for chromatography R. Flow rate 30 mL\/min.<\/p>\n Temperature:<\/p>\n \u2014 column: 130 \u00b0C;<\/p>\n \u2014 injection port and detector: 200 \u00b0C.<\/p>\n Detection\u00a0 Flame ionisation.<\/p>\n Injection\u00a0 1 \u00b5L.<\/p>\n Run time\u00a0 3 times the retention time of camphor.<\/p>\n System suitability:<\/p>\n \u2014 resolution: minimum 1.5 between the peaks due to camphor and bornyl acetate in the chromatogram obtained with reference solution (a);<\/p>\n \u2014 signal-to-noise ratio: minimum 5 for the principal peak in the chromatogram obtained with reference solution (b).<\/p>\n Limits:<\/p>\n \u2014 any impurity: for each impurity, not more than 2 per cent of the area of the principal peak;<\/p>\n \u2014 total: not more than 4 per cent of the area of the principal peak;<\/p>\n \u2014 disregard limit: the area of the principal peak in the chromatogram obtained with reference solution (b).<\/p>\n Maximum 100 ppm.<\/p>\n Dissolve 1.0 g in 10 mL of 2-propanol R in a distillation flask. Add 1.5 mL of dilute sodium hydroxide solution R and 50 mg of nickel-aluminium alloy R. Heat on a water-bath until the 2-propanol R has evaporated. Allow to cool and add 5 mL of water R. Mix and filter through a wet filter previously washed with water R until free from chlorides. Dilute the filtrate to 10.0 mL with water R. To 5.0 mL of this solution, add nitric acid R dropwise until the precipitate which forms is redissolved and dilute to 15 mL with water R. The solution complies with the limit test for chlorides (2.4.4).<\/p>\n Dissolve 1 g in 10 mL of light petroleum R. The solution is clear (2.2.1).<\/p>\n Maximum 0.05 per cent.<\/p>\n Evaporate 2.0 g on a water-bath and dry at 100-105 \u00b0C for 1 h. The residue weighs not more than 1 mg.<\/p>\n","protected":false},"excerpt":{"rendered":" Edition: BP 2025 (Ph. Eur. 11.6 update) Action and use Counter-irritant. Preparations Camphorated Opium Tincture Concentrated Camphorated Opium Tincture Concentrated Camphor Water DEFINITION (1RS,4RS)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one. CHARACTERS Appearance White or almost white, crystalline powder or friable, crystalline masses, highly volatile even at room temperature. Solubility Slightly soluble in water, very soluble in ethanol (96 per cent) and…<\/p>\n","protected":false},"author":5,"featured_media":28833,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-28832","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28832","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=28832"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28832\/revisions"}],"predecessor-version":[{"id":28836,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28832\/revisions\/28836"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/28833"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=28832"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=28832"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=28832"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}DEFINITION<\/h2>\n
CHARACTERS<\/h2>\n
Appearance<\/h3>\n
Solubility<\/h3>\n
IDENTIFICATION<\/h2>\n
TESTS<\/h2>\n
Solution S<\/h3>\n
Appearance of solution<\/h3>\n
Acidity or alkalinity<\/h3>\n
Related substances<\/h3>\n
Halogens<\/h3>\n
Water<\/h3>\n
Residue on evaporation<\/h3>\n