{"id":28742,"date":"2025-11-08T17:22:58","date_gmt":"2025-11-08T10:22:58","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=28742"},"modified":"2025-11-08T17:22:58","modified_gmt":"2025-11-08T10:22:58","slug":"prochlorperazine-mesilate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/prochlorperazine-mesilate\/","title":{"rendered":"Prochlorperazine Mesilate"},"content":{"rendered":"<p>C<sub>20<\/sub>H<sub>24<\/sub>ClN<sub>3<\/sub>S,2CH<sub>4<\/sub>SO<sub>3<\/sub> 566.2 5132-55-8<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Dopamine receptor antagonist; neuroleptic.<\/p>\n<p><strong>Preparations<\/strong><\/p>\n<p>Prochlorperazine Injection<\/p>\n<p>Prochlorperazine Oral Solution<\/p>\n<h2>DEFINITION<\/h2>\n<p>Prochlorperazine Mesilate is 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine di(methanesulfonate). It contains not less than 98.0% and not more than 101.0% of C20H24ClN3S,2CH4SO3 , calculated with reference to the dried substance.<\/p>\n<h2>PRODUCTION<\/h2>\n<p>Risk assessment should be used to evaluate the potential for genotoxic methanesulfonate esters to be formed in the presence of low molecular weight alcohols. If a risk of methanesulfonate ester formation is identified through risk assessment, these impurities should not exceed the threshold of toxicological concern.<\/p>\n<h2>CHARACTERISTICS<\/h2>\n<p>A white or almost white powder.<\/p>\n<p>Very soluble in water; sparingly soluble in ethanol (96%); practically insoluble in ether.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. The infrared absorption spectrum, Appendix II A, is concordant with the reference spectrum of prochlorperazine mesilate (RS 290).<\/p>\n<p>B. Dissolve 5 mg in 2 mL of sulfuric acid and allow to stand for 5 minutes. A red colour is produced.<\/p>\n<h2>TESTS<\/h2>\n<h3>Acidity<\/h3>\n<p>pH of a 2% w\/v solution, 2.0 to 3.0, Appendix V L.<\/p>\n<h3>Related substances<\/h3>\n<p>Complies with the test for related substances in phenothiazines, Appendix III A, using mobile phase A and dissolving the substance being examined in methanol containing 0.5% v\/v of 13.5M ammonia.<\/p>\n<h3>Loss on drying<\/h3>\n<p>When dried to constant weight at 100\u00b0 at a pressure not exceeding 0.7 kPa, loses not more than 1.0% of its weight. Use 1 g.<\/p>\n<h3>Sulfated ash<\/h3>\n<p>Not more than 0.1%, Appendix IX A.<\/p>\n<h2>ASSAY<\/h2>\n<p>Dissolve 0.8 g in 10 mL of water, add 5 mL of 1M sodium hydroxide and extract by shaking with successive quantities of 50, 25, 25 and 25 mL of ether. Wash the combined ether extracts with 5 mL of water, shake the washings with 5 mL of ether, add the ether to the combined ether extracts and evaporate to dryness. Add 2 mL of absolute ethanol to the residue, evaporate to dryness and carry out Method I for non-aqueous titration,<\/p>\n<p>Appendix VIII A, using 1-naphtholbenzein solution as indicator. Each mL of 0.1M perchloric acid VS is equivalent to 28.31 mg of C<sub>20<\/sub>H<sub>24<\/sub>ClN<sub>3<\/sub>S,2CH<sub>4<\/sub>SO<sub>3<\/sub>.<\/p>\n<h2>STORAGE<\/h2>\n<p>Prochlorperazine Mesilate should be protected from light.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>C20H24ClN3S,2CH4SO3 566.2 5132-55-8 Action and use Dopamine receptor antagonist; neuroleptic. Preparations Prochlorperazine Injection Prochlorperazine Oral Solution DEFINITION Prochlorperazine Mesilate is 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine di(methanesulfonate). It contains not less than 98.0% and not more than 101.0% of C20H24ClN3S,2CH4SO3 , calculated with reference to the dried substance. PRODUCTION Risk assessment should be used to evaluate the potential for genotoxic&#8230;<\/p>\n","protected":false},"author":4,"featured_media":28757,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-28742","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28742","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=28742"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28742\/revisions"}],"predecessor-version":[{"id":28759,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28742\/revisions\/28759"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/28757"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=28742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=28742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=28742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}