{"id":28257,"date":"2025-11-08T11:06:27","date_gmt":"2025-11-08T04:06:27","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=28257"},"modified":"2025-11-08T11:06:27","modified_gmt":"2025-11-08T04:06:27","slug":"prednisolone","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/prednisolone\/","title":{"rendered":"Prednisolone"},"content":{"rendered":"<p><em>(Ph. Eur. monograph 0353)<\/em><\/p>\n<p>C<sub>21<\/sub>H<sub>28<\/sub>O<sub>5<\/sub> 360.5 50-24-8<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Glucocorticoid.<\/p>\n<p><strong>Preparations<\/strong><\/p>\n<p>Prednisolone Tablets<\/p>\n<p>Prednisolone Gastro-resistant Tablets<\/p>\n<h2>DEFINITION<\/h2>\n<p>11\u03b2,17,21-Trihydroxypregna-1,4-diene-3,20-dione.<\/p>\n<h3>Content<\/h3>\n<p>96.5 per cent to 102.0 per cent (dried substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>White or almost white, crystalline, hygroscopic powder.<\/p>\n<h3>Solubility<\/h3>\n<p>Very slightly soluble in water, soluble in ethanol (96 per cent) and in methanol, sparingly soluble in acetone, slightly soluble in methylene chloride.<\/p>\n<p>It shows polymorphism (5.9).<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>First identification: A, B.<\/p>\n<p>Second identification: C, D.<\/p>\n<p>A. Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison: prednisolone CRS.<\/p>\n<p>If the spectra obtained in the solid state show differences, dissolve the substance to be examined and the reference substance separately in the minimum volume of acetone R, evaporate to dryness on a water-bath and record new spectra using the residues.<\/p>\n<p>B. Examine the chromatograms obtained in the assay.<\/p>\n<p>Results: The principal peak in the chromatogram obtained with test solution (b) is similar in retention time and size to the principal peak in the chromatogram obtained with reference solution (d).<\/p>\n<p>C. Thin-layer chromatography (2.2.27).<\/p>\n<p>Test solution: Dissolve 10 mg of the substance to be examined in the mobile phase and dilute to 10.0 mL with the mobile phase.<\/p>\n<p>Reference solution: Dissolve 10 mg of prednisolone CRS in the mobile phase and dilute to 10.0 mL with the mobile phase.<\/p>\n<p>Plate: TLC silica gel F254 plate R.<\/p>\n<p>Mobile phase: methanol R, methylene chloride R (10:90 V\/V).<\/p>\n<p>Application: 5 \u03bcL.<\/p>\n<p>Development: Over 3\/4 of the plate.<\/p>\n<p>Drying: In air.<\/p>\n<p>Detection: Spray with a solution prepared as follows: dissolve 0.25 g of 2,4-dihydroxybenzaldehyde R in glacial acetic acid R, dilute to 50 mL with the same solvent and add a mixture of 12.5 mL of sulfuric acid R and 37.5 mL of glacial acetic acid R; heat the plate at 90 \u00b0C for 35 min or until the spots appear, allow to cool and examine in daylight and in ultraviolet light at 365 nm.<\/p>\n<p>Results: The principal spot in the chromatogram obtained with the test solution is similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution.<\/p>\n<p>D. Add about 2 mg to 2 mL of sulfuric acid R and shake to dissolve. Within 5 min, an intense red colour develops. When examined in ultraviolet light at 365 nm, a brownish-red fluorescence is seen. Add this solution to 10 mL of water R and mix.<\/p>\n<p>The colour fades and there is a strong yellowish-green fluorescence in ultraviolet light at 365 nm.<\/p>\n<h2>TESTS<\/h2>\n<h3>Specific optical rotation (2.2.7)<\/h3>\n<p>+ 113 to + 119 (dried substance).<\/p>\n<p>Dissolve 0.250 g in ethanol (96 per cent) R and dilute to 25.0 mL with the same solvent.<\/p>\n<h3>Related substances<\/h3>\n<p>Liquid chromatography (2.2.29). Carry out the test protected from light.<\/p>\n<p>Solvent mixture acetonitrile R, water R (40:60 V\/V).<\/p>\n<p>Test solution (a): Dissolve 10 mg of the substance to be examined in the solvent mixture and dilute to 20.0 mL with the solvent mixture.<\/p>\n<p>Test solution (b): Dissolve 25.0 mg of the substance to be examined in the solvent mixture and dilute to 20.0 mL with the solvent mixture. Dilute 1.0 mL of the solution to 10.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (a): Dissolve 5 mg of prednisolone for system suitability CRS (containing impurities A, B and C) in the solvent mixture and dilute to 10 mL with the solvent mixture.<\/p>\n<p>Reference solution (b): Dissolve 5 mg of prednisolone for peak identification CRS (containing impurities F and J) in the solvent mixture and dilute to 10 mL with the solvent mixture.<\/p>\n<p>Reference solution (c): Dilute 1.0 mL of test solution (a) to 100.0 mL with the solvent mixture. Dilute 1.0 mL of this solution to 10.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (d): Dissolve 25.0 mg of prednisolone CRS in the solvent mixture and dilute to 20.0 mL with the solvent mixture. Dilute 1.0 mL of the solution to 10.0 mL with the solvent mixture.<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.15 m, \u00d8 = 4.6 mm;<\/p>\n<p>\u2014 stationary phase: end-capped octadecylsilyl silica gel for chromatography compatible with 100 per cent aqueous mobile phases R (3 \u03bcm);<\/p>\n<p>\u2014 temperature: 40 \u00b0C.<\/p>\n<p>Mobile phase:<\/p>\n<p>\u2014 mobile phase A: water for chromatography R;<\/p>\n<p>\u2014 mobile phase B: acetonitrile R, methanol R (50:50 V\/V);<\/p>\n<table style=\"border-collapse: collapse; width: 100%;\">\n<tbody>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\"><strong>Time<\/strong><br \/>\n<strong>(min)<\/strong><\/td>\n<td style=\"width: 33.3333%; text-align: center;\"><strong>Mobile phase A<\/strong><br \/>\n<strong>(per cent V\/V)<\/strong><\/td>\n<td style=\"width: 33.3333%; text-align: center;\"><strong>Mobile phase B<\/strong><br \/>\n<strong>(per cent V\/V)<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">0 &#8211; 14<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">60<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">40<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">14 &#8211; 20<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">60 \u2192 20<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">40 \u2192 80<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 33.3333%; text-align: center;\">20 &#8211; 25<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">20<\/td>\n<td style=\"width: 33.3333%; text-align: center;\">80<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Flow rate: 1 mL\/min.<\/p>\n<p>Detection: Spectrophotometer at 254 nm.<\/p>\n<p>Injection: 10 \u03bcL of test solution (a) and reference solutions (a), (b) and (c).<\/p>\n<p>Identification of impurities: Use the chromatogram supplied with prednisolone for system suitability CRS and the chromatogram obtained with reference solution (a) to identify the peaks due to impurities A, B and C; use the chromatogram supplied with prednisolone for peak identification CRS and the chromatogram obtained with reference solution (b) to identify the peaks due to impurities F and J.<\/p>\n<p>Relative retention: With reference to prednisolone (retention time = about 12 min): impurity F = about 0.7; impurity B = about 0.9; impurity A = about 1.05; impurity J = about 1.5; impurity C = about 1.7.<\/p>\n<p>System suitability: Reference solution (a):<\/p>\n<p>\u2014 peak-to-valley ratio: minimum 3, where Hp = height above the baseline of the peak due to impurity A and Hv = height above the baseline of the lowest point of the curve separating this peak from the peak due to prednisolone.<\/p>\n<p>Limits:<\/p>\n<p>\u2014 impurity A: not more than 10 times the area of the principal peak in the chromatogram obtained with reference solution (c) (1.0 per cent);<\/p>\n<p>\u2014 impurity F: not more than 5 times the area of the principal peak in the chromatogram obtained with reference solution (c) (0.5 per cent);<\/p>\n<p>\u2014 impurities B, C, J: for each impurity, not more than 3 times the area of the principal peak in the chromatogram obtained with reference solution (c) (0.3 per cent);<\/p>\n<p>\u2014 unspecified impurities: for each impurity, not more than the area of the principal peak in the chromatogram obtained with reference solution (c) (0.10 per cent);<\/p>\n<p>\u2014 total: not more than 15 times the area of the principal peak in the chromatogram obtained with reference solution (c) (1.5 per cent);<\/p>\n<p>\u2014 disregard limit: 0.5 times the area of the principal peak in the chromatogram obtained with reference solution (c) (0.05 per cent).<\/p>\n<h3>Loss on drying (2.2.32)<\/h3>\n<p>Maximum 1.0 per cent, determined on 0.500 g by drying in an oven at 105 \u00b0C.<\/p>\n<h2>ASSAY<\/h2>\n<p>Liquid chromatography (2.2.29) as described in the test for related substances with the following modification.<\/p>\n<p>Injection: Test solution (b) and reference solution (d).<\/p>\n<p>Calculate the percentage content of C<sub>21<\/sub>H<sub>28<\/sub>O<sub>5<\/sub> taking into account the assigned content of prednisolone CRS.<\/p>\n<h2>STORAGE<\/h2>\n<p>In an airtight container, protected from light.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>Specified impurities A, B, C, F, J.<\/p>\n<p>Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for other\/unspecified impurities and\/or by the general monograph Substances for pharmaceutical use (2034). It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10. Control of impurities in substances for pharmaceutical use) D, E, G, H, I.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-28265\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/2-37-300x163.jpg\" alt=\"Prednisolone \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/2-37-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/2-37-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/2-37-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/2-37.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>A. 11\u03b2,17,21-trihydroxypregn-4-ene-3,20-dione (hydrocortisone),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-28266\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-36-300x163.jpg\" alt=\"Prednisolone \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-36-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-36-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-36-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-36.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>B. 17,21-dihydroxypregna-1,4-diene-3,11,20-trione (prednisone),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-28267\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/4-34-300x163.jpg\" alt=\"Prednisolone \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/4-34-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/4-34-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/4-34-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/4-34.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>C. 11\u03b2,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate (prednisolone acetate),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-28268\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/5-33-300x163.jpg\" alt=\"Prednisolone \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/5-33-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/5-33-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/5-33-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/5-33.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>D. 6\u03b2,11\u03b2,17,21-tetrahydroxypregna-1,4-diene-3,20-dione (6\u03b2-hydroxyprednisolone),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-28269\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-29-300x163.jpg\" alt=\"Prednisolone \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-29-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-29-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-29-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-29.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>E. 11\u03b2,14\u03b1,17,21-tetrahydroxypregna-1,4-diene-3,20-dione (14\u03b1-hydroxyprednisolone),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-28270\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/7-26-300x163.jpg\" alt=\"Prednisolone \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/7-26-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/7-26-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/7-26-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/7-26.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>F. 11\u03b1,17,21-trihydroxypregna-1,4-diene-3,20-dione (11-epi-prednisolone),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-28271\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/8-20-300x163.jpg\" alt=\"Prednisolone \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/8-20-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/8-20-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/8-20-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/8-20.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>G. 11\u03b2,17,20S,21-tetrahydroxypregna-1,4-dien-3-one ((20S)-hydroxyprednisolone),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-28272\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/9-16-300x163.jpg\" alt=\"Prednisolone \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/9-16-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/9-16-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/9-16-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/9-16.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>H. 11\u03b2,17,21-trihydroxypregna-1,4,6-triene-3,20-dione (\u0394 -prednisolone), 6<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-28273\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/10-11-300x163.jpg\" alt=\"Prednisolone \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/10-11-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/10-11-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/10-11-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/10-11.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>I. 11\u03b2,21-dihydroxypregna-1,4-diene-3,20-dione (17-deoxyprednisolone),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-28274\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/11-9-300x163.jpg\" alt=\"Prednisolone \" width=\"300\" height=\"163\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/11-9-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/11-9-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/11-9-768x416.jpg 768w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/11-9.jpg 1200w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>J. 17,21-dihydroxypregna-1,4-diene-3,20-dione (11-deoxyprednisolone).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 0353) C21H28O5 360.5 50-24-8 Action and use Glucocorticoid. Preparations Prednisolone Tablets Prednisolone Gastro-resistant Tablets DEFINITION 11\u03b2,17,21-Trihydroxypregna-1,4-diene-3,20-dione. Content 96.5 per cent to 102.0 per cent (dried substance). CHARACTERS Appearance White or almost white, crystalline, hygroscopic powder. Solubility Very slightly soluble in water, soluble in ethanol (96 per cent) and in methanol, sparingly soluble&#8230;<\/p>\n","protected":false},"author":4,"featured_media":28276,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-28257","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28257","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=28257"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28257\/revisions"}],"predecessor-version":[{"id":28278,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28257\/revisions\/28278"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/28276"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=28257"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=28257"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=28257"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}