{"id":28041,"date":"2025-11-07T16:40:39","date_gmt":"2025-11-07T09:40:39","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=28041"},"modified":"2025-11-07T16:41:10","modified_gmt":"2025-11-07T09:41:10","slug":"montelukast-sodium","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/montelukast-sodium\/","title":{"rendered":""},"content":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n<p>(Ph. Eur. monograph 2583)<\/p>\n<p>C<sub>35<\/sub>H<sub>35<\/sub>ClNNaO<sub>3<\/sub>S\u2003 608\u2003 151767-02-1<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Leukotriene CysLT1 receptor antagonist; treatment of asthma.<\/p>\n<p>Preparations<\/p>\n<p>Montelukast Chewable Tablets<br \/>\nMontelukast Granules<br \/>\nMontelukast Tablets<\/p>\n<p>Ph Eur<\/p>\n<h2>DEFINITION<\/h2>\n<p>Sodium [1-[[[(1R)-1-[3-[(1E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetate.<\/p>\n<p>Content<\/p>\n<p>98.0 per cent to 102.0 per cent (anhydrous substance).<\/p>\n<p>Montelukast Sodium<\/p>\n<h2>CHARACTERS<\/h2>\n<p>Appearance<br \/>\nWhite or almost white, hygroscopic powder.<\/p>\n<p>Solubility<br \/>\nFreely soluble in water and in methylene chloride, freely soluble to very soluble in ethanol (96 per cent).<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A.\u2003Infrared absorption spectrophotometry (2.2.24).<br \/>\nComparison montelukast sodium CRS.<\/p>\n<p>B.\u2003Enantiomeric purity (see Tests).<br \/>\nC.\u2003Ignite 0.1 g in a crucible until an almost white residue is obtained. Take up the residue in 2 mL of water R and filter. The filtrate gives reaction (a) of sodium (2.3.1).<\/p>\n<h2>TESTS<\/h2>\n<p>Enantiomeric purity<\/p>\n<p>Liquid chromatography (2.2.29). Carry out the test protected from light. Prepare the solutions in amber glass flasks.<\/p>\n<p>Solvent mixture acetonitrile R, water R (50:50 V\/V).<\/p>\n<p>Test solution Dissolve 50 mg of the substance to be examined in the solvent mixture and dilute to 50.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (a) Dilute 1 mL of the test solution to 100 mL with the solvent mixture. Dilute 1 mL of this solution to 10 mL with the solvent mixture.<\/p>\n<p>Reference solution (b) Dissolve the contents of a vial of montelukast racemate CRS in 1 mL of the solvent mixture.<\/p>\n<p>Column:<br \/>\n\u2014 size: l = 0.15 m, \u00d8 = 4.0 mm;<br \/>\n\u2014 stationary phase: \u03b11-acid-glycoprotein silica gel for chiral separation R (5 \u00b5m);<br \/>\n\u2014 temperature: 30 \u00b0C.<\/p>\n<p>Mobile phase:<br \/>\n\u2014 mobile phase A: 2.3 g\/L solution of ammonium acetate R adjusted to pH 5.7 with glacial acetic acid R;<br \/>\n\u2014 mobile phase B: acetonitrile R, methanol R (40:60 V\/V);<\/p>\n<table>\n<thead>\n<tr>\n<th>Time (min)<\/th>\n<th>Mobile phase A (per cent V\/V)<\/th>\n<th>Mobile phase B (per cent V\/V)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>0 &#8211; 30<\/td>\n<td>70 \u2192 60<\/td>\n<td>30 \u2192 40<\/td>\n<\/tr>\n<tr>\n<td>30 &#8211; 35<\/td>\n<td>60<\/td>\n<td>40<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Flow rate 0.9 mL\/min.<\/p>\n<p>Detection Spectrophotometer at 280 nm.<\/p>\n<p>Injection 10 \u00b5L.<\/p>\n<p>Relative retention With reference to montelukast (retention time = about 28 min): impurity A = about 0.8.<\/p>\n<p>Identification of impurities Use the chromatogram obtained with reference solution (b) to identify the peak due to impurity A.<\/p>\n<p>System suitability:<br \/>\n\u2014 resolution: minimum 2.9 between the peaks due to impurity A and montelukast in the chromatogram obtained with reference solution (b);<br \/>\n\u2014 signal-to-noise ratio: minimum 10 for the principal peak in the chromatogram obtained with reference solution (a).<\/p>\n<p>Calculation of percentage content:<\/p>\n<p>\u2014 calculate the ratio of the area of the peak due to impurity A to the sum of the areas of the peaks due to montelukast and impurity A.<\/p>\n<p>Limit:<br \/>\n\u2014 impurity A: maximum 0.2 per cent.<\/p>\n<p>Related substances<\/p>\n<p>Liquid chromatography (2.2.29): use the normalisation procedure. Carry out the test protected from light. Prepare the solutions in amber glass flasks.<\/p>\n<p>Solvent mixture water R, methanol R (10:90 V\/V).<\/p>\n<p>Test solution (a) Dissolve 50.0 mg of the substance to be examined in the solvent mixture and dilute to 50.0 mL with the solvent mixture.<\/p>\n<p>Test solution (b) Dilute 10.0 mL of test solution (a) to 100.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (a) Dilute 1.0 mL of test solution (a) to 100.0 mL with the solvent mixture. Dilute 1.0 mL of this solution to 20.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (b) Dissolve 10 mg of montelukast for peak identification CRS (containing impurities B, C, D, E and F) in the solvent mixture and dilute to 10.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (c) In order to prepare impurity G in situ, transfer 1 mL of reference solution (b) to a colourless glass vial and expose to ambient light for about 20 min.<\/p>\n<p>Reference solution (d) Dissolve 65.0 mg of montelukast dicyclohexylamine CRS in the solvent mixture and dilute to 50.0 mL with the solvent mixture. Dilute 10.0 mL of the solution to 100.0 mL with the solvent mixture.<\/p>\n<p>Column:<br \/>\n\u2014 size: l = 0.05 m, \u00d8 = 4.6 mm;<br \/>\n\u2014 stationary phase: phenylsilyl silica gel for chromatography R (1.8 \u00b5m);<br \/>\n\u2014 temperature: 30 \u00b0C.<\/p>\n<p>Mobile phase:<br \/>\n\u2014 mobile phase A: mix 1.5 mL of trifluoroacetic acid R and 1000 mL of water for chromatography R;<br \/>\n\u2014 mobile phase B: mix 1.5 mL of trifluoroacetic acid R and 1000 mL of acetonitrile for chromatography R;<\/p>\n<table>\n<thead>\n<tr>\n<th>Time (min)<\/th>\n<th>Mobile phase A (per cent V\/V)<\/th>\n<th>Mobile phase B (per cent V\/V)<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>0 &#8211; 3<\/td>\n<td>60<\/td>\n<td>40<\/td>\n<\/tr>\n<tr>\n<td>3 &#8211; 16<\/td>\n<td>60 \u2192 49<\/td>\n<td>40 \u2192 51<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Flow rate 1.2 mL\/min.<\/p>\n<p>Detection Spectrophotometer at 238 nm.<\/p>\n<p>Injection 10 \u00b5L of test solution (a) and reference solutions (a) and (c); 20 \u00b5L of reference solution (b).<\/p>\n<p>Identification of impurities Use the chromatogram supplied with montelukast for peak identification CRS and the chromatogram obtained with reference solution (b) to identify the peaks due to impurities B, C, D, E and F; use the chromatogram obtained with reference solution (c) to identify the peak due to impurity G.<\/p>\n<p>Relative retention With reference to montelukast (retention time = about 8 min): impurity C peak 1 = about 0.37; impurity C peak 2 = about 0.43; impurity G = about 0.8; impurities D and E = about 0.9; impurity F = about 1.2; impurity B = about 1.9.<\/p>\n<p>System suitability Reference solution (c):<\/p>\n<p>\u2014 resolution: minimum 2.5 between the peaks due to impurity G and montelukast; minimum 1.5 between the peaks due to montelukast and impurity F.<\/p>\n<p>Limits:<\/p>\n<p>\u2014 impurity B: maximum 0.3 per cent;<br \/>\n\u2014 impurity C: for the sum of the areas of the 2 peaks, maximum 0.2 per cent;<br \/>\n\u2014 impurities F, G: for each impurity, maximum 0.15 per cent;<br \/>\n\u2014 sum of impurities D and E: maximum 0.15 per cent;<br \/>\n\u2014 unspecified impurities: for each impurity, maximum 0.10 per cent;<br \/>\n\u2014 total: maximum 0.6 per cent;<br \/>\n\u2014 disregard limit: the area of the principal peak in the chromatogram obtained with reference solution (a) (0.05 per cent).<\/p>\n<p>Water (2.5.12)<\/p>\n<p>Maximum 4.0 per cent, determined on 0.300 g.<\/p>\n<h2>ASSAY<\/h2>\n<p>Liquid chromatography (2.2.29) as described in the test for related substances with the following modifications.<\/p>\n<p>Injection Test solution (b) and reference solution (d).<\/p>\n<p>Calculate the percentage content of C<sub>35<\/sub>H<sub>35<\/sub>ClNNaO<sub>3<\/sub>S using the following expression:<\/p>\n<p>A\u2081 \u00d7 m\u2082 \u00d7 79.24 \u00d7 p)<br data-start=\"258\" data-end=\"261\" \/>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8211;<br data-start=\"290\" data-end=\"293\" \/>A\u2082 \u00d7 m\u2081 \u00d7 (100 \u2013 a)<\/p>\n<p>A1 = area of the principal peak in the chromatogram obtained with test solution (b);<\/p>\n<p>A2 = area of the principal peak in the chromatogram obtained with reference solution (d);<\/p>\n<p>m1 = mass of the substance to be examined used to prepare test solution (a), in milligrams;<\/p>\n<p>m2 = mass of montelukast dicyclohexylamine CRS used to prepare reference solution (d), in milligrams;<\/p>\n<p>p = declared percentage content of montelukast dicyclohexylamine CRS;<\/p>\n<p>a = percentage content of water in the substance to be examined.<\/p>\n<h2>STORAGE<\/h2>\n<p>In an airtight container, protected from light.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>Specified impurities A, B, C, D, E, F, G.<\/p>\n<p>Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for other\/unspecified impurities and\/or by the general monograph Substances for pharmaceutical use (2034). It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10. Control of impurities in substances for pharmaceutical use) H, I.<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_28042\" aria-describedby=\"caption-attachment-28042\" style=\"width: 1200px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-28042\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-1.jpg\" alt=\"\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-1.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-1-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-1-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-1-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-28042\" class=\"wp-caption-text\">A.\u2003[1-[[[(1S)-1-[3-[(1E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid,<\/figcaption><\/figure>\n<figure id=\"attachment_28043\" aria-describedby=\"caption-attachment-28043\" style=\"width: 1200px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-28043\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-2.jpg\" alt=\"\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-2.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-2-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-2-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-2-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-28043\" class=\"wp-caption-text\">B.\u2003[1-[[[(1R)-1-[3-[(1E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(prop-1-en-2-yl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid,<\/figcaption><\/figure><figure id=\"attachment_28044\" aria-describedby=\"caption-attachment-28044\" style=\"width: 1200px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-28044\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-3.jpg\" alt=\"\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-3.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-3-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-3-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-3-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-28044\" class=\"wp-caption-text\">C.\u2003[1-[[(\u039e)-[(1\u039e)-1-[3-[(1E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propane-1-sulfinyl]]methyl]cyclopropyl]acetic acid,<\/figcaption><\/figure><figure id=\"attachment_28045\" aria-describedby=\"caption-attachment-28045\" style=\"width: 1200px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-28045\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-4.jpg\" alt=\"\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-4.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-4-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-4-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-4-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-28045\" class=\"wp-caption-text\">D.\u2003[1-[[[(1R)-1-[3-[(1R)-1-[[[1-(carboxymethyl)cyclopropyl]methyl]sulfanyl]-2-(7-chloro\u00acquinolin-2-yl)ethyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid,<\/figcaption><\/figure>&nbsp;<\/p>\n<figure id=\"attachment_28046\" aria-describedby=\"caption-attachment-28046\" style=\"width: 1200px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-28046\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-5.jpg\" alt=\"\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-5.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-5-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-5-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-5-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-28046\" class=\"wp-caption-text\">E.\u2003[1-[[[(1R)-1-[3-[(1S)-1-[[[1-(carboxymethyl)cyclopropyl]methyl]sulfanyl]-2-(7-chloroquinolin-2-yl)ethyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid,<\/figcaption><\/figure>\n<figure id=\"attachment_28047\" aria-describedby=\"caption-attachment-28047\" style=\"width: 1200px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-28047\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-6.jpg\" alt=\"\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-6.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-6-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-6-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-6-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-28047\" class=\"wp-caption-text\">F.\u2003[1-[[[(1R)-3-(2-acetylphenyl)-1-[3-[(1E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid,<\/figcaption><\/figure>\n<figure id=\"attachment_28048\" aria-describedby=\"caption-attachment-28048\" style=\"width: 1200px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-28048\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-7.jpg\" alt=\"\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-7.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-7-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-7-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-7-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-28048\" class=\"wp-caption-text\">G.\u2003[1-[[[(1R)-1-[3-[(1Z)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid,<\/figcaption><\/figure>\n<figure id=\"attachment_28049\" aria-describedby=\"caption-attachment-28049\" style=\"width: 1200px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-28049\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-8.jpg\" alt=\"\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-8.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-8-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-8-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-8-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-28049\" class=\"wp-caption-text\">H.\u2003[1-[[[(1R)-1-[3-[(1E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(methoxycarbonyl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid,<\/figcaption><\/figure>\n<figure id=\"attachment_28050\" aria-describedby=\"caption-attachment-28050\" style=\"width: 1200px\" class=\"wp-caption alignnone\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-28050\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-9.jpg\" alt=\"\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-9.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-9-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-9-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Montelukast-Sodium-9-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><figcaption id=\"caption-attachment-28050\" class=\"wp-caption-text\">I.\u2003(RS)-1-[[[(1R)-1-[3-[(1E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl]methyl]cyclopropyl<br \/>acetic acid.<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update) (Ph. Eur. monograph 2583) C35H35ClNNaO3S\u2003 608\u2003 151767-02-1 Action and use Leukotriene CysLT1 receptor antagonist; treatment of asthma. Preparations Montelukast Chewable Tablets Montelukast Granules Montelukast Tablets Ph Eur DEFINITION Sodium [1-[[[(1R)-1-[3-[(1E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetate. Content 98.0 per cent to 102.0 per cent (anhydrous substance). Montelukast Sodium CHARACTERS Appearance White or almost white,&#8230;<\/p>\n","protected":false},"author":5,"featured_media":28052,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-28041","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28041","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=28041"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28041\/revisions"}],"predecessor-version":[{"id":28054,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/28041\/revisions\/28054"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/28052"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=28041"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=28041"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=28041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}