{"id":27857,"date":"2025-11-07T11:58:41","date_gmt":"2025-11-07T04:58:41","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=27857"},"modified":"2025-11-07T11:58:41","modified_gmt":"2025-11-07T04:58:41","slug":"potassium-sorbate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/potassium-sorbate\/","title":{"rendered":"Potassium Sorbate"},"content":{"rendered":"<p><em>(Ph. Eur. monograph 0618)<\/em><\/p>\n<p>C<sub>6<\/sub>H<sub>7<\/sub>KO<sub>2<\/sub> 150.2 24634-61-5<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Antimicrobial preservative.<\/p>\n<h2>DEFINITION<\/h2>\n<p>Potassium (E,E)-hexa-2,4-dienoate.<\/p>\n<h3>Content<\/h3>\n<p>99.0 per cent to 101.0 per cent (dried substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>White or almost white powder or granules.<\/p>\n<h3>Solubility<\/h3>\n<p>Very soluble in water, slightly soluble in ethanol (96 per cent).<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>First identification: B, D.<\/p>\n<p>Second identification: A, C, D.<\/p>\n<p>A. Ultraviolet and visible absorption spectrophotometry (2.2.25).<\/p>\n<p>Test solution: Dissolve 50.0 mg in water R and dilute to 250.0 mL with the same solvent. Dilute 2.0 mL of this solution to<\/p>\n<p>200.0 mL with 0.1 M hydrochloric acid.<\/p>\n<p>Spectral range 230-350 nm.<\/p>\n<p>Absorption maximum At 264 nm.<\/p>\n<p>Specific absorbance at the absorption maximum 1650 to 1900.<\/p>\n<p>B. Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison: potassium sorbate CRS.<\/p>\n<p>C. Dissolve 1.0 g in 50 mL of water R, add 10 mL of dilute hydrochloric acid R and shake. Filter the crystalline precipitate, wash with water R and dry in vacuo over sulfuric acid R for 4 h. The residue obtained melts (2.2.14) at 132 \u00b0C to 136 \u00b0C.<\/p>\n<p>D. Dissolve 0.2 g in 2 mL of water R and add 2 mL of dilute acetic acid R. Filter. The solution gives reaction (b) of potassium (2.3.1).<\/p>\n<h2>TESTS<\/h2>\n<h3>Solution S<\/h3>\n<p>Dissolve 2.5 g in carbon dioxide-free water R and dilute to 50 mL with the same solvent.<\/p>\n<h3>Appearance of solution<\/h3>\n<p>Solution S is clear (2.2.1) and not more intensely coloured than reference solution Y5 (2.2.2, Method II).<\/p>\n<h3>Acidity or alkalinity<\/h3>\n<p>To 20 mL of solution S add 0.1 mL of phenolphthalein solution R. Not more than 0.25 mL of 0.1 M sodium hydroxide or 0.1 M hydrochloric acid is required to change the colour of the indicator.<\/p>\n<h3>Aldehydes<\/h3>\n<p>Maximum 0.15 per cent, expressed as C<sub>2<\/sub>H<sub>4<\/sub>O.<\/p>\n<p>Dissolve 1.0 g in a mixture of 30 mL of water R and 50 mL of 2-propanol R, adjust to pH 4 with 1 M hydrochloric acid and dilute to 100 mL with water R. To 10 mL of the solution add 1 mL of decolorised fuchsin solution R and allow to stand for 30 min. Any colour in the solution is not more intense than that in a standard prepared at the same time by adding 1 mL of decolorised fuchsin solution R to a mixture of 1.5 mL of acetaldehyde standard solution (100 ppm C2H4O) R, 4 mL of 2- propanol R and 4.5 mL of water R.<\/p>\n<h3>Loss on drying (2.2.32)<\/h3>\n<p>Maximum 1.0 per cent, determined on 1.000 g by drying in an oven at 105 \u00b0C for 3 h.<\/p>\n<h2>ASSAY<\/h2>\n<p>Dissolve 0.120 g in 20 mL of anhydrous acetic acid R. Titrate with 0.1 M perchloric acid using 0.1 mL of crystal violet solution R as indicator until the colour changes from violet to bluish-green.<\/p>\n<p>1 mL of 0.1 M perchloric acid is equivalent to 15.02 mg of C<sub>6<\/sub>H<sub>7<\/sub>KO<sub>2<\/sub>.<\/p>\n<h2>STORAGE<\/h2>\n<p>Protected from light.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 0618) C6H7KO2 150.2 24634-61-5 Action and use Antimicrobial preservative. DEFINITION Potassium (E,E)-hexa-2,4-dienoate. Content 99.0 per cent to 101.0 per cent (dried substance). CHARACTERS Appearance White or almost white powder or granules. Solubility Very soluble in water, slightly soluble in ethanol (96 per cent). IDENTIFICATION First identification: B, D. Second identification: A, C,&#8230;<\/p>\n","protected":false},"author":4,"featured_media":27864,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-27857","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/27857","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=27857"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/27857\/revisions"}],"predecessor-version":[{"id":27866,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/27857\/revisions\/27866"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/27864"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=27857"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=27857"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=27857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}