{"id":27665,"date":"2025-11-07T10:04:21","date_gmt":"2025-11-07T03:04:21","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=27665"},"modified":"2025-11-07T10:14:02","modified_gmt":"2025-11-07T03:14:02","slug":"minocycline-hydrochloride-dihydrate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/minocycline-hydrochloride-dihydrate\/","title":{"rendered":"Minocycline Hydrochloride Dihydrate"},"content":{"rendered":"<p>BP 2025 (Ph. Eur. 11.6 update)<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27700\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-2.jpg\" alt=\"Minocycline Hydrochloride Dihydrate\" width=\"576\" height=\"312\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-2.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-2-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-2-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-2-768x416.jpg 768w\" sizes=\"auto, (max-width: 576px) 100vw, 576px\" \/><\/p>\n<p>C<sub>23<\/sub>H<sub>28<\/sub>ClN<sub>3<\/sub>O<sub>7<\/sub>,2H<sub>2<\/sub>O 530.0 128420-71-3<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Tetracycline antibacterial.<\/p>\n<p><strong>Preparations<\/strong><\/p>\n<p>Minocycline Capsules<br \/>\nMinocycline Prolonged-release Capsules<br \/>\nMinocycline Tablets<\/p>\n<p>DEFINITION<\/p>\n<p>(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride dihydrate.<\/p>\n<p>Semi-synthetic product derived from a fermentation product.<\/p>\n<p><strong>Content<\/strong><\/p>\n<p>94.5 per cent to 102.0 per cent (anhydrous substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<p><strong>Appearance<\/strong><\/p>\n<p>Yellow, hygroscopic, crystalline powder.<\/p>\n<p><strong>Solubility<\/strong><\/p>\n<p>Sparingly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and carbonates.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>First identification: A, C.<\/p>\n<p>Second identification: B, C.<\/p>\n<p>A. Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison minocycline hydrochloride CRS.<\/p>\n<p>B. Thin-layer chromatography (2.2.27).<\/p>\n<p>Test solution Dissolve 5 mg of the substance to be examined in methanol R and dilute to 10 mL with the same solvent.<br \/>\nReference solution (a) Dissolve 5 mg of minocycline hydrochloride CRS in methanol R and dilute to 10 mL with the same solvent.<br \/>\nReference solution (b) Dissolve 5 mg of minocycline hydrochloride CRS and 5 mg of oxytetracycline hydrochloride CRS in methanol R and dilute to 10 mL with the same solvent.<br \/>\nPlate TLC octadecylsilyl silica gel F254 plate R.<br \/>\nMobile phase Mix 20 volumes of acetonitrile R, 20 volumes of methanol R and 60 volumes of a 63 g\/L solution of oxalic acid R previously adjusted to pH 2 with concentrated ammonia R.<br \/>\nApplication 1 \u03bcL.<br \/>\nDevelopment Over 3\/4 of the plate.<br \/>\nDrying In air.<br \/>\nDetection Examine in ultraviolet light at 254 nm.<br \/>\nSystem suitability Reference solution (b):<br \/>\n\u2014 the chromatogram shows 2 clearly separated spots.<br \/>\nResults The principal spot in the chromatogram obtained with the test solution is similar in position and size to the principal spot in the chromatogram obtained with reference solution (a).<\/p>\n<p>C. It gives reaction (a) of chlorides (2.3.1).<\/p>\n<h2>TESTS<\/h2>\n<p>Solution S<\/p>\n<p>Dissolve 0.200 g in carbon dioxide-free water R and dilute to 20.0 mL with the same solvent.<\/p>\n<p><strong>Appearance of solution<\/strong><\/p>\n<p>The solution is clear (2.2.1) and its absorbance (2.2.25) at 450 nm using a 1 cm cell is not greater than 0.23.<br \/>\nDilute 1.0 mL of solution S to 10.0 mL with water R.<\/p>\n<p>pH (2.2.3)<br \/>\n3.5 to 4.5 for solution S.<\/p>\n<p><strong>Light-absorbing impurities<\/strong><\/p>\n<p>Carry out the measurement within 1 h of preparing solution S.<br \/>\nThe absorbance (2.2.25) of solution S measured at 560 nm is not greater than 0.06.<\/p>\n<p><strong>Related substances<\/strong><\/p>\n<p>Liquid chromatography (2.2.29). Carry out the test protected from light. Store the solutions at 2-8 \u00b0C and use them within 3 h of preparation.<br \/>\nSolution A Mix 18 volumes of a 3.75 g\/L solution of sodium edetate R and 60 volumes of a 28.3 g\/L solution of ammonium oxalate R and adjust to pH 7.2 with dilute ammonia R2.<\/p>\n<p>Test solution Dissolve 24.0 mg of the substance to be examined in water R and dilute to 100.0 mL with the same solvent.<br \/>\nReference solution (a) Dilute 1.0 mL of the test solution to 100.0 mL with water R.<br \/>\nReference solution (b) Dissolve 2 mg of minocycline for system suitability CRS (containing impurities A, B, C, E, F, G and H) in water R and dilute to 5 mL with the same solvent.<\/p>\n<p>Column:<br \/>\n\u2014 size: l = 0.25 m, \u00d8 = 4.6 mm;<br \/>\n\u2014 stationary phase: base-deactivated end-capped octadecylsilyl silica gel for chromatography R (5 \u03bcm);<br \/>\n\u2014 temperature: 40 \u00b0C.<\/p>\n<p>Mobile phase tetrahydrofuran R, dimethylformamide R, solution A (8:12:78 V\/V\/V).<br \/>\nFlow rate 1.5 mL\/min.<br \/>\nDetection Spectrophotometer at 280 nm.<br \/>\nInjection 20 \u03bcL of the test solution and reference solutions (a) and (b).<br \/>\nRun time 3 times the retention time of minocycline.<\/p>\n<p>Identification of impurities Use the chromatogram supplied with minocycline for system suitability CRS and the chromatogram obtained with reference solution (b) to identify the peaks due to impurities A, B, C, E, F, G and H.<br \/>\nRelative retention With reference to minocycline (retention time = about 16 min): impurity C = about 0.52; impurity H = about 0.55; impurity B = about 0.66; impurity A = about 0.74; impurity G = about 0.79; impurity F = about 0.92; impurity E = about 2.6.<\/p>\n<p>System suitability Reference solution (b):<br \/>\n\u2014 resolution: minimum 1.5 between the peaks due to impurities C and H; minimum 1.5 between the peaks due to impurities A and G; minimum 1.5 between the peaks due to impurity F and minocycline.<\/p>\n<p>Calculation of percentage contents:<br \/>\n\u2014 correction factors: multiply the peak areas of the following impurities by the corresponding correction factor: impurity E = 1.6; impurity F = 1.6; impurity G = 1.4;<br \/>\n\u2014 for each impurity, use the concentration of minocycline hydrochloride dihydrate in reference solution (a).<\/p>\n<p>Limits:<br \/>\n\u2014 impurity A: maximum 1.2 per cent;<br \/>\n\u2014 impurity B: maximum 0.8 per cent;<br \/>\n\u2014 impurities C, E: for each impurity, maximum 0.6 per cent;<br \/>\n\u2014 impurities F, G: for each impurity, maximum 0.5 per cent;<br \/>\n\u2014 impurity H: maximum 0.3 per cent;<br \/>\n\u2014 any other impurity: for each impurity, maximum 0.15 per cent;<br \/>\n\u2014 total: maximum 3.5 per cent;<br \/>\n\u2014 reporting threshold: 0.05 per cent.<\/p>\n<p><strong>Water (2.5.12)<\/strong><br \/>\n5.0 per cent to 8.0 per cent, determined on 0.200 g.<\/p>\n<p><strong>Sulfated ash (2.4.14)<\/strong><br \/>\nMaximum 0.5 per cent, determined on 1.0 g.<\/p>\n<p><strong>Bacterial endotoxins (2.6.14)<\/strong><br \/>\nLess than 1.25 IU\/mg, if intended for use in the manufacture of parenteral preparations without a further appropriate procedure for the removal of bacterial endotoxins.<\/p>\n<h2>ASSAY<\/h2>\n<p>Liquid chromatography (2.2.29) as described in the test for related substances with the following modifications.<br \/>\nTest solution Dissolve 30.0 mg of the substance to be examined in water R and dilute to 50.0 mL with the same solvent.<\/p>\n<p>Reference solution Dissolve 30.0 mg of minocycline hydrochloride CRS in water R and dilute to 50.0 mL with the same solvent.<br \/>\nInjection Test solution and reference solution.<br \/>\nCalculate the percentage content of C<sub>23<\/sub>H<sub>28<\/sub>ClN<sub>3<\/sub>O<sub>7 <\/sub>taking into account the assigned content of minocycline hydrochloride CRS.<\/p>\n<h2>STORAGE<\/h2>\n<p>In an airtight container, protected from light. If the substance is sterile, the container is also sterile and tamper-evident.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>Specified impurities A, B, C, E, F, G, H.<br \/>\nOther detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for other\/unspecified impurities. It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10. Control of impurities in substances for pharmaceutical use) D, I.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27714\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-3.jpg\" alt=\"Minocycline Hydrochloride Dihydrate\" width=\"640\" height=\"347\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-3.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-3-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-3-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-3-768x416.jpg 768w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><br \/>\nA. (4R,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (4-epiminocycline),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27718\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-4-1.jpg\" alt=\"Minocycline Hydrochloride Dihydrate\" width=\"721\" height=\"391\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-4-1.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-4-1-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-4-1-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-4-1-768x416.jpg 768w\" sizes=\"auto, (max-width: 721px) 100vw, 721px\" \/><br \/>\nB. (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (sancycline),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27721\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-5.jpg\" alt=\"Minocycline Hydrochloride Dihydrate\" width=\"784\" height=\"425\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-5.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-5-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-5-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-5-768x416.jpg 768w\" sizes=\"auto, (max-width: 784px) 100vw, 784px\" \/><br \/>\nC. (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-(methylamino)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (7-monodemethylminocycline),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27722\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-6.jpg\" alt=\"Minocycline Hydrochloride Dihydrate\" width=\"791\" height=\"429\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-6.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-6-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-6-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-6-768x416.jpg 768w\" sizes=\"auto, (max-width: 791px) 100vw, 791px\" \/><br \/>\nD. (4S,4aS,5aR,12aS)-7-amino-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (7-aminosancycline),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27723\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-7.jpg\" alt=\"Minocycline Hydrochloride Dihydrate\" width=\"808\" height=\"438\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-7.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-7-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-7-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-7-768x416.jpg 768w\" sizes=\"auto, (max-width: 808px) 100vw, 808px\" \/><br \/>\nE. (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12a-trihydroxy-12-imino-1,11-dioxo-1,4,4a,5,5a,6,11,11a,12,12a-decahydrotetracene-2-carboxamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27724\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-8.jpg\" alt=\"Minocycline Hydrochloride Dihydrate\" width=\"808\" height=\"438\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-8.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-8-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-8-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-8-768x416.jpg 768w\" sizes=\"auto, (max-width: 808px) 100vw, 808px\" \/><br \/>\nF. (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-N-(hydroxymethyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27725\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-9.jpg\" alt=\"Minocycline Hydrochloride Dihydrate\" width=\"784\" height=\"425\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-9.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-9-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-9-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-9-768x416.jpg 768w\" sizes=\"auto, (max-width: 784px) 100vw, 784px\" \/><br \/>\nG. (4S,4aS,5aR,12aS)-4,7,9-tris(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27726\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-10.jpg\" alt=\"Minocycline Hydrochloride Dihydrate\" width=\"795\" height=\"431\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-10.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-10-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-10-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-10-768x416.jpg 768w\" sizes=\"auto, (max-width: 795px) 100vw, 795px\" \/><br \/>\nH. (4S,4aS,12aS)-4,7-bis(dimethylamino)-3,10,11,12a-tetrahydroxy-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-27727\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-11.jpg\" alt=\"Minocycline Hydrochloride Dihydrate\" width=\"747\" height=\"405\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-11.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-11-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-11-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/Minocycline-Hydrochloride-Dihydrate-11-768x416.jpg 768w\" sizes=\"auto, (max-width: 747px) 100vw, 747px\" \/><br \/>\nI. (4S,4aS,5aR,12aS)-9-amino-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide (9-aminosancycline).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BP 2025 (Ph. Eur. 11.6 update) C23H28ClN3O7,2H2O 530.0 128420-71-3 Action and use Tetracycline antibacterial. Preparations Minocycline Capsules Minocycline Prolonged-release Capsules Minocycline Tablets DEFINITION (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride dihydrate. Semi-synthetic product derived from a fermentation product. Content 94.5 per cent to 102.0 per cent (anhydrous substance). CHARACTERS Appearance Yellow, hygroscopic, crystalline powder. Solubility Sparingly soluble in water, slightly&#8230;<\/p>\n","protected":false},"author":5,"featured_media":27701,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-27665","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/27665","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=27665"}],"version-history":[{"count":4,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/27665\/revisions"}],"predecessor-version":[{"id":27738,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/27665\/revisions\/27738"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/27701"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=27665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=27665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=27665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}