{"id":26941,"date":"2025-11-06T14:29:41","date_gmt":"2025-11-06T07:29:41","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=26941"},"modified":"2025-11-06T14:29:41","modified_gmt":"2025-11-06T07:29:41","slug":"oxetacaine","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/oxetacaine\/","title":{"rendered":"Oxetacaine"},"content":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n

Action and use<\/strong><\/p>\n

Local anaesthetic.<\/p>\n

DEFINITION<\/h2>\n

Oxetacaine is 2,2\u2032-(2-hydroxyethylimino)bis[N-(\u03b1,\u03b1-dimethylphenethyl)-N-methylacetamide]. It contains not less than 99.0% and not more than 100.5% of C28<\/sub>H41<\/sub>N3<\/sub>O3<\/sub>, calculated with reference to the dried substance.<\/p>\n

CHARACTERISTICS<\/h2>\n

A white or almost white powder.<\/p>\n

Practically insoluble in water; freely soluble in methanol; soluble in ethyl acetate.<\/p>\n

IDENTIFICATION<\/h2>\n

The infrared absorption spectrum, Appendix II A, is concordant with the reference spectrum of oxetacaine\u00a0(RS 254).<\/p>\n

TESTS<\/h2>\n

Melting point<\/h3>\n

100\u00b0C to 104\u00b0C, Appendix V A.<\/p>\n

Related substances<\/h3>\n

Carry out the method for thin-layer chromatography, Appendix III A, using the following solutions in ethyl acetate.<\/p>\n

(1) 10.0% w\/v of the substance being examined.<\/p>\n

(2) Dilute 1 volume of solution (1) to 200 volumes.<\/p>\n

(3) Dilute 1 volume of solution (2) to 5 volumes.<\/p>\n

CHROMATOGRAPHIC CONDITIONS<\/h4>\n

(a) Use a silica gel 60 precoated plate (Merck plates are suitable).<\/p>\n

(b) Use the mobile phase as described below.<\/p>\n

(c) Apply 5 \u00b5L of each solution.<\/p>\n

(d) Develop the plate to 15 cm.<\/p>\n

(e) After removal of the plate, dry it in a current of warm air and spray liberally with a solution containing 6% w\/v of ammonium thiocyanate and 2% w\/v of cobalt(II) chloride. Carefully remove excess solution by applying filter paper to the plate and allow the plate to dry in air for 10 minutes or until spots appear.<\/p>\n

MOBILE PHASE<\/h4>\n

1 volume of 18M ammonia, 20 volumes of absolute ethanol and 79 volumes of toluene.<\/p>\n

LIMITS<\/h4>\n

In the chromatogram obtained with solution (1):<\/p>\n

any secondary spot is not more intense than the spot in the chromatogram obtained with solution (2) (0.5%);<\/p>\n

not more than one secondary spot is more intense than the spot in the chromatogram obtained with solution (3) (0.1%).<\/p>\n

Loss on drying<\/h3>\n

When dried at 60\u00b0C at a pressure not exceeding 0.7 kPa for 4 hours, loses not more than 0.5% of its weight. Use 1 g.<\/p>\n

Sulfated ash<\/h3>\n

Not more than 0.1%, Appendix IX A.<\/p>\n

ASSAY<\/h2>\n

Dissolve 1 g in 50 mL of anhydrous acetic acid and carry out Method I for non-aqueous titration, Appendix VIII A, determining the end-point potentiometrically. Each mL of 0.1M\u00a0 perchloric acid VS is equivalent to 46.76 mg of C28<\/sub>H41<\/sub>N3<\/sub>O3<\/sub>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update) Action and use Local anaesthetic. DEFINITION Oxetacaine is 2,2\u2032-(2-hydroxyethylimino)bis[N-(\u03b1,\u03b1-dimethylphenethyl)-N-methylacetamide]. It contains not less than 99.0% and not more than 100.5% of C28H41N3O3, calculated with reference to the dried substance. CHARACTERISTICS A white or almost white powder. Practically insoluble in water; freely soluble in methanol; soluble in ethyl acetate….<\/p>\n","protected":false},"author":5,"featured_media":26942,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-26941","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/26941","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=26941"}],"version-history":[{"count":3,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/26941\/revisions"}],"predecessor-version":[{"id":26952,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/26941\/revisions\/26952"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/26942"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=26941"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=26941"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=26941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}