(Ph. Eur. monograph 0351)<\/p>\n
C6<\/sub>H12<\/sub>O3<\/sub>\u00a0 \u00a0 \u00a0 132.2\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0123-63-7<\/p>\n Action and use<\/strong><\/p>\n Anticonvulsant.<\/p>\n 2,4,6-Trimethyl-1,3,5-trioxane (cyclic trimer of acetaldehyde).<\/p>\n It may contain a suitable quantity of an antioxidant.<\/p>\n Colourless or slightly yellow, transparent liquid. It solidifies on cooling to form a crystalline mass.<\/p>\n Soluble in water, but less soluble in boiling water, miscible with ethanol (96 per cent) and with essential oils.<\/p>\n A. Solution S (see Tests) is clear (2.2.1) but becomes turbid on warming.<\/p>\n B. To 5 mL add 0.1 mL of dilute sulfuric acid R and heat. Acetaldehyde, recognisable by its odour, is evolved.<\/p>\n C. To 5 mL of solution S in a test-tube add 5 mL of ammoniacal silver nitrate solution R and heat in a water-bath. Silver is deposited as a mirror on the wall of the tube.<\/p>\n Dissolve 20.0 mL in carbon dioxide-free water R and dilute to 200.0 mL with the same solvent.<\/p>\n To 50.0 mL of solution S add 0.05 mL of phenolphthalein solution R. Not more than 1.5 mL of 0.1 M sodium hydroxide is required to change the colour of the indicator.<\/p>\n 1.403 to 1.406.<\/p>\n 0.991 to 0.996.<\/p>\n A maximum of 10 per cent distils below 123 \u00b0C and a minimum of 95 per cent distils below 126 \u00b0C.<\/p>\n 10 \u00b0C to 13 \u00b0C.<\/p>\n To 5.0 mL add a mixture of 0.2 mL of methyl orange solution R, 5 mL of ethanol (60 per cent V\/V) R and 5 mL of alcoholic hydroxylamine solution R and shake. Not more than 0.8 mL of 0.5 M sodium hydroxide is required to change the colour of the indicator to pure yellow.<\/p>\n Place 50.0 mL of solution S in a ground-glass-stoppered flask, add 5 mL of dilute sulfuric acid R and 10 mL of potassium iodide solution R, close the flask and allow to stand protected from light for 15 min. Titrate with 0.1 M sodium thiosulfate using 1 mL of starch solution R as indicator. Allow to stand for 5 min and, if necessary complete the titration. Not more than 2.0 mL of 0.1 M sodium thiosulfate is required.<\/p>\n Maximum 0.6 g\/L.<\/p>\n Heat 5.0 mL in a tared evaporating dish on a water-bath and dry at 105 \u00b0C for 1 h. The residue weighs a maximum of 3 mg.<\/p>\n In a small, well-filled, airtight container, protected from light. If the substance has solidified the whole contents of the (Ph. Eur. monograph 0351) C6H12O3\u00a0 \u00a0 \u00a0 132.2\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0123-63-7 Action and use Anticonvulsant. DEFINITION 2,4,6-Trimethyl-1,3,5-trioxane (cyclic trimer of acetaldehyde). It may contain a suitable quantity of an antioxidant. CHARACTERS Appearance Colourless or slightly yellow, transparent liquid. It solidifies on cooling to form a crystalline mass. Solubility Soluble in water, but less…<\/p>\n","protected":false},"author":2,"featured_media":26561,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174,1],"tags":[],"class_list":["post-26524","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances","category-volumes-1-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/26524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=26524"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/26524\/revisions"}],"predecessor-version":[{"id":26545,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/26524\/revisions\/26545"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/26561"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=26524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=26524"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=26524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}DEFINITION<\/h2>\n
CHARACTERS<\/h2>\n
Appearance<\/h3>\n
Solubility<\/h3>\n
IDENTIFICATION<\/h2>\n
TESTS<\/h2>\n
Solution S<\/h3>\n
Acidity<\/h3>\n
Refractive index (2.2.6)<\/h4>\n
Relative density (2.2.5)<\/h4>\n
Distillation range (2.2.11)<\/h4>\n
Freezing point (2.2.18)<\/h4>\n
Acetaldehyde<\/h4>\n
Peroxides<\/h4>\n
Non-volatile residue<\/h3>\n
STORAGE<\/h2>\n
\ncontainer must be liquefied before use.<\/p>\n","protected":false},"excerpt":{"rendered":"