{"id":26384,"date":"2025-11-05T16:14:38","date_gmt":"2025-11-05T09:14:38","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=26384"},"modified":"2025-11-05T16:14:38","modified_gmt":"2025-11-05T09:14:38","slug":"palmitic-acid","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/palmitic-acid\/","title":{"rendered":"Palmitic Acid"},"content":{"rendered":"

General Notices<\/p>\n

(Ph. Eur. monograph 1904)<\/p>\n

57-10-3<\/p>\n

Action and use<\/strong><\/p>\n

Excipient.<\/p>\n

DEFINITION<\/h2>\n

Hexadecanoic acid (C16<\/sub>H32<\/sub>O2<\/sub>; Mr<\/sub> 256.4), obtained from fats or oils of vegetable or animal origin.<\/p>\n

Content<\/h3>\n

Minimum 92.0 per cent.<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

White or almost white, waxy solid.<\/p>\n

Solubility<\/h3>\n

Practically insoluble in water, soluble in ethanol (96 per cent).<\/p>\n

IDENTIFICATION<\/h2>\n

A. Freezing point (see Tests).<\/p>\n

B. Acid value (2.5.1): 216 to 220, determined on 0.1 g.<\/p>\n

C. Examine the chromatograms obtained in the assay.<\/p>\n

Results: The principal peak in the chromatogram obtained with the test solution is similar in retention time to the principal peak in the chromatogram obtained with the reference solution.<\/p>\n

TESTS<\/h2>\n

Appearance<\/h3>\n

Heat the substance to be examined to about 75 \u00b0C. The resulting liquid is not more intensely coloured than reference solution Y7<\/sub> or BY7<\/sub> (2.2.2, Method I).<\/p>\n

Acidity<\/h3>\n

Melt 5.0 g, stir for 2 min in 10 mL of hot carbon dioxide-free water R, cool slowly and filter. To the filtrate add 0.05 mL of methyl orange solution R. No red colour develops.<\/p>\n

Freezing point (2.2.18)<\/h4>\n

60 \u00b0C to 66 \u00b0C.<\/p>\n

Iodine value (2.5.4)<\/h4>\n

Maximum 1.<\/p>\n

Stearic acid<\/h4>\n

Maximum 6.0 per cent, determined as prescribed in the assay.<\/p>\n

ASSAY<\/h2>\n

Gas chromatography (2.4.22, Method C) with the following modifications. Prepare the solutions as described in the method but omitting the initial hydrolysis.<\/p>\n

Reference solution: Prepare the reference solution in the same manner as the test solution using a mixture of 50 mg of palmitic acid R and 50 mg of stearic acid R instead of the substance to be examined.<\/p>\n

Relative retention: With reference to methyl stearate: methyl palmitate = about 0.9.<\/p>\n

System suitability:<\/p>\n

\u2014 resolution: minimum 5.0 between the peaks due to methyl stearate and methyl palmitate.<\/p>\n","protected":false},"excerpt":{"rendered":"

General Notices (Ph. Eur. monograph 1904) 57-10-3 Action and use Excipient. DEFINITION Hexadecanoic acid (C16H32O2; Mr 256.4), obtained from fats or oils of vegetable or animal origin. Content Minimum 92.0 per cent. CHARACTERS Appearance White or almost white, waxy solid. Solubility Practically insoluble in water, soluble in ethanol (96 per cent). IDENTIFICATION A. Freezing point…<\/p>\n","protected":false},"author":2,"featured_media":26386,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-26384","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/26384","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=26384"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/26384\/revisions"}],"predecessor-version":[{"id":26388,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/26384\/revisions\/26388"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/26386"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=26384"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=26384"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=26384"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}