{"id":25701,"date":"2025-11-04T16:32:06","date_gmt":"2025-11-04T09:32:06","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=25701"},"modified":"2025-11-04T17:00:35","modified_gmt":"2025-11-04T10:00:35","slug":"octoxinol-10","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/octoxinol-10\/","title":{"rendered":"Octoxinol 10"},"content":{"rendered":"<p><em>(Ph. Eur. monograph 1553)<\/em><\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Excipient.<\/p>\n<h2>DEFINITION<\/h2>\n<p>\u03b1-[4-(2,4,4-Trimethylpentan-2-yl)phenyl]-\u03c9-hydroxydeca(oxyethane-1,2-diyl).<\/p>\n<p>Mixture consisting mainly of mono-octylphenyl ethers of macrogols corresponding to the formula C<sub>8<\/sub>H<sub>17<\/sub>C<sub>6<\/sub>H<sub>4<\/sub>-[OCH<sub>2<\/sub>-CH<sub>2<\/sub>]n-OH where the average value of n is 10 (C<sub>34<\/sub>H<sub>62<\/sub>O<sub>11<\/sub>; Mr 646). It may contain free macrogols.<\/p>\n<h2>CHARACTERS<\/h2>\n<h3>Appearance<\/h3>\n<p>Clear, colourless or light yellow, viscous liquid.<\/p>\n<h3>Solubility<\/h3>\n<p>Miscible with water, with ethanol (96 per cent) and with vegetable oils.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison: octoxinol 10 CRS.<\/p>\n<p>Preparation: Film between sodium chloride R plates.<\/p>\n<p>B. Cloud point (see Tests).<\/p>\n<h2>TESTS<\/h2>\n<h3>Acidity or alkalinity<\/h3>\n<p>Boil 1.0 g with 20 mL of carbon dioxide-free water R for 1 min, with constant stirring. Cool and filter. To 10 mL of the filtrate, add 0.05 mL of bromothymol blue solution R1. Not more than 0.5 mL of 0.01 M<br \/>\nhydrochloric acid or 0.01 M sodium hydroxide is required to change the colour of the indicator.<\/p>\n<h3>Hydroxyl value (2.5.3, Method A)<\/h3>\n<p>85 to 101. Calculate the hydroxyl value using the following expression:<\/p>\n<p style=\"text-align: center;\">I<sub>OH<\/sub> = 28.05 (n<sub>2<\/sub> &#8211; n<sub>1<\/sub>)\/ m<\/p>\n<h3>Cloud point<\/h3>\n<p>63 \u00b0C to 70 \u00b0C.<\/p>\n<p>Dissolve 1.0 g in 99 g of water R. Transfer about 30 mL of the solution to a test-tube, heat on a water-bath and stir continuously until the solution becomes cloudy. Remove the test-tube from the water-bath (ensuring<br \/>\nthat the temperature does not increase more than 2 \u00b0C), and continue to stir. The cloud point is the temperature at which the solution becomes sufficiently clear that the entire thermometer bulb is plainly seen.<\/p>\n<h3>Ethylene oxide and dioxan (2.4.25)<\/h3>\n<p>Maximum 1 ppm of ethylene oxide and maximum 10 ppm of dioxan.<\/p>\n<h3>Water (2.5.12)<\/h3>\n<p>Maximum 0.5 per cent, determined on 2.00 g.<\/p>\n<h3>Total ash (2.4.16)<\/h3>\n<p>Maximum 0.4 per cent, determined on 1.0 g.<\/p>\n<h2>STORAGE<\/h2>\n<p>In an airtight container.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>(Ph. Eur. monograph 1553) Action and use Excipient. DEFINITION \u03b1-[4-(2,4,4-Trimethylpentan-2-yl)phenyl]-\u03c9-hydroxydeca(oxyethane-1,2-diyl). Mixture consisting mainly of mono-octylphenyl ethers of macrogols corresponding to the formula C8H17C6H4-[OCH2-CH2]n-OH where the average value of n is 10 (C34H62O11; Mr 646). It may contain free macrogols. CHARACTERS Appearance Clear, colourless or light yellow, viscous liquid. Solubility Miscible with water, with ethanol (96&#8230;<\/p>\n","protected":false},"author":4,"featured_media":25708,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-25701","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/25701","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=25701"}],"version-history":[{"count":4,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/25701\/revisions"}],"predecessor-version":[{"id":25785,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/25701\/revisions\/25785"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/25708"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=25701"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=25701"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=25701"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}