{"id":24999,"date":"2025-11-03T17:14:08","date_gmt":"2025-11-03T10:14:08","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=24999"},"modified":"2025-11-06T16:30:54","modified_gmt":"2025-11-06T09:30:54","slug":"metaraminol-tartrate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/metaraminol-tartrate\/","title":{"rendered":"Metaraminol Tartrate"},"content":{"rendered":"

(Ph. Eur. 11.6 update)<\/p>\n

C9<\/sub>H13<\/sub>NO2<\/sub>,C4<\/sub>H6<\/sub>O6<\/sub> 317.3 17171-57-2<\/p>\n

Action and use<\/strong><\/p>\n

Adrenoceptor agonist.<\/p>\n

Preparation<\/strong><\/p>\n

Metaraminol Injection<\/p>\n

DEFINITION<\/h2>\n

Metaraminol Tartrate is (1R,2S)-2-amino-1-(3-hydroxyphenyl)propan-1-ol hydrogen (2R,3R)-tartrate. It contains not less than 99.0% and not more than 101.0% of C9<\/sub>H13<\/sub>NO2<\/sub>,C4<\/sub>H6<\/sub>O6<\/sub>, calculated with reference to the dried substance.<\/p>\n

CHARACTERISTICS<\/h2>\n

A white, crystalline powder.<\/p>\n

Freely soluble in water; sparingly soluble in ethanol (96%); practically insoluble in ether.<\/p>\n

IDENTIFICATION<\/h2>\n

A. In the test for Related substances the principal spot in the chromatogram obtained with solution (2) corresponds to that in the chromatogram obtained with solution (4).<\/p>\n

B. To 0.5 mL of a 0.05% w\/v solution add 0.5 mL of phosphomolybdotungstic reagent and 5 mL of dilute sodium carbonate solution and allow to stand for 5 minutes. An intense blue colour is produced.<\/p>\n

C. To 4 mL of a 0.05% w\/v solution add 5 mL of borate buffer pH 9.6 and 1 mL of a freshly prepared 0.5% w\/v solution of sodium 1,2-naphthaquinone 4-sulfonate and allow to stand for 1 minute. Add 0.2 mL of a 2% v\/v solution of benzalkonium chloride solution and 5 mL of toluene and shake. A mauve colour is immediately produced in the toluene layer (distinction from phenylephrine).<\/p>\n

TESTS<\/h2>\n

Acidity<\/h3>\n

pH of a 5% w\/v solution, 3.2 to 3.5, Appendix V L.<\/p>\n

Phenones<\/h3>\n

Absorbance of a 0.2% w\/v solution at 310 nm, not more than 0.2, calculated with reference to the dried substance, Appendix II B.<\/p>\n

Related substances<\/h3>\n

Carry out in subdued light the method for thin-layer chromatography, Appendix III A, using the following solutions in methanol.<\/p>\n

(1) 1.0% w\/v of the substance being examined.<\/p>\n

(2) 0.050% w\/v of the substance being examined.<\/p>\n

(3) 0.0050% w\/v of the substance being examined.<\/p>\n

(4) 0.050% w\/v of metaraminol tartrate BPCRS.<\/p>\n

CHROMATOGRAPHIC CONDITIONS<\/h4>\n

(a) Use a silica gel precoated plate (Merck silica gel 60 plates are suitable).<\/p>\n

(b) Use the mobile phase as described below.<\/p>\n

(c) Apply 10 \u03bcL of each solution.<\/p>\n

(d) Develop the plate to 15 cm.<\/p>\n

(e) After removal of the plate, dry in air and spray with a solution prepared in the following manner. Mix 25 mL of a 0.45% w\/v solution of sulfanilic acid in 1M hydrochloric acid with 1.5 mL of a 5% w\/v solution of sodium nitrite, allow to stand for 5 minutes and mix cautiously with 25 mL of 2M sodium carbonate.<\/p>\n

MOBILE PHASE<\/h4>\n

10 volumes of 13.5M ammonia, 80 volumes of chloroform and 80 volumes of methanol.<\/p>\n

LIMITS<\/h4>\n

Any secondary spot in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (3) (0.5%).<\/p>\n

Loss on drying<\/h3>\n

When dried to constant weight at 105\u00b0, loses not more than 0.5% of its weight. Use 1 g.<\/p>\n

Sulfated ash<\/h3>\n

Not more than 0.1%, Appendix IX A.<\/p>\n

ASSAY<\/h2>\n

Carry out Method I for non-aqueous titration, Appendix VIII A, using 0.6 g and crystal violet solution as indicator. Each mL of 0.1M perchloric acid VS is equivalent to 31.73 mg of C9<\/sub>H13<\/sub>NO2<\/sub>,C4<\/sub>H6<\/sub>O6<\/sub>.<\/p>\n","protected":false},"excerpt":{"rendered":"

(Ph. Eur. 11.6 update) C9H13NO2,C4H6O6 317.3 17171-57-2 Action and use Adrenoceptor agonist. Preparation Metaraminol Injection DEFINITION Metaraminol Tartrate is (1R,2S)-2-amino-1-(3-hydroxyphenyl)propan-1-ol hydrogen (2R,3R)-tartrate. It contains not less than 99.0% and not more than 101.0% of C9H13NO2,C4H6O6, calculated with reference to the dried substance. CHARACTERISTICS A white, crystalline powder. Freely soluble in water; sparingly soluble in ethanol…<\/p>\n","protected":false},"author":5,"featured_media":25023,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-24999","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/24999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=24999"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/24999\/revisions"}],"predecessor-version":[{"id":25026,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/24999\/revisions\/25026"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/25023"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=24999"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=24999"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=24999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}