{"id":24649,"date":"2025-11-03T14:49:45","date_gmt":"2025-11-03T07:49:45","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=24649"},"modified":"2025-11-03T14:49:45","modified_gmt":"2025-11-03T07:49:45","slug":"sodium-calcium-edetate-intravenous-infusion-for-veterinary-use","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/sodium-calcium-edetate-intravenous-infusion-for-veterinary-use\/","title":{"rendered":"Sodium Calcium Edetate Intravenous Infusion for Veterinary Use"},"content":{"rendered":"<p><strong>Action and use<\/strong><\/p>\n<p>Chelating agent.<\/p>\n<h2>DEFINITION<\/h2>\n<p>Sodium Calcium Edetate Intravenous Infusion for Veterinary Use is a sterile solution of Sodium Calcium Edetate. It is prepared immediately before use by diluting Sodium Calcium Edetate Sterile Concentrate for Veterinary Use with a suitable diluent in accordance with the manufacturer\u2019s instructions.<\/p>\n<p>The intravenous infusion complies with the requirements stated under Parenteral Preparations and with the following requirement.<\/p>\n<h2>LABELLING<\/h2>\n<p>The quantity of active ingredient is stated in terms of the equivalent amount of anhydrous sodium calcium edetate in a suitable dose-volume.<\/p>\n<h3>SODIUM CALCIUM EDETATE STERILE CONCENTRATE FOR VETERINARY USE<\/h3>\n<h3>DEFINITION<\/h3>\n<p>Sodium Calcium Edetate Sterile Concentrate for Veterinary Use is a sterile solution of Sodium Calcium Edetate in Water for Injections containing the equivalent of 25.0% w\/v of anhydrous sodium calcium edetate.<\/p>\n<p>The concentrate complies with the requirements for Concentrates for Injections or Infusions stated under Parenteral Preparations and with the following requirements.<\/p>\n<h3>Content of anhydrous sodium calcium edetate, C<sub>10<\/sub>H<sub>12<\/sub>CaN<sub>2<\/sub>Na<sub>2<\/sub>O<sub>8<\/sub><\/h3>\n<p>22.5 to 27.5% w\/v.<\/p>\n<h2>CHARACTERISTICS<\/h2>\n<p>A colourless solution.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. Dilute 2.5 mL with 7.5 mL of water, make alkaline to litmus paper with 5M ammonia and add 5 mL of a 2.5% w\/v solution of ammonium oxalate. Not more than a trace of precipitate is produced.<\/p>\n<p>B. To 10 mL add 2 mL of a 10% w\/v solution of lead(II) nitrate, shake and add 5 mL of dilute potassium iodide solution; no yellow precipitate is produced. Make alkaline to litmus paper with 5M ammonia and add 5 mL of a 2.5% w\/v solution of ammonium oxalate; a white precipitate is produced.<\/p>\n<p>C. Evaporate to dryness and ignite. The residue yields the reactions characteristic of sodium salts and of calcium salts, Appendix VI.<\/p>\n<h2>TESTS<\/h2>\n<h3>Acidity or alkalinity<\/h3>\n<p>pH, 6.5 to 8.0, Appendix V L.<\/p>\n<h4>Bacterial endotoxins<\/h4>\n<p>Carry out the test for bacterial endotoxins, Appendix XIV C. The endotoxin limit concentration is not more than 0.125 IU per mg of sodium calcium edetate.<\/p>\n<h2>ASSAY<\/h2>\n<p>To 2.5 mL add 90 mL of water, 7 g of hexamine and 5 mL of 2M hydrochloric acid and titrate with 0.05M lead nitrate VS using xylenol orange solution as indicator. Each mL of 0.05M lead nitrate VS is equivalent to 18.71 mg of C<sub>10<\/sub>H<sub>12<\/sub>CaN<sub>2<\/sub>Na<sub>2<\/sub>O<sub>8<\/sub>.<\/p>\n<h2>STORAGE<\/h2>\n<p>Sodium Calcium Edetate Sterile Concentrate for Veterinary Use should be kept in containers made from lead-free glass.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Action and use Chelating agent. DEFINITION Sodium Calcium Edetate Intravenous Infusion for Veterinary Use is a sterile solution of Sodium Calcium Edetate. It is prepared immediately before use by diluting Sodium Calcium Edetate Sterile Concentrate for Veterinary Use with a suitable diluent in accordance with the manufacturer\u2019s instructions. The intravenous infusion complies with the requirements&#8230;<\/p>\n","protected":false},"author":2,"featured_media":24666,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[176],"tags":[],"class_list":["post-24649","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-british-pharmacopoeia-veterinary-2020"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/24649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=24649"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/24649\/revisions"}],"predecessor-version":[{"id":24668,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/24649\/revisions\/24668"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/24666"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=24649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=24649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=24649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}