{"id":23657,"date":"2025-11-01T08:53:18","date_gmt":"2025-11-01T01:53:18","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=23657"},"modified":"2025-11-01T08:54:35","modified_gmt":"2025-11-01T01:54:35","slug":"magnesium-citrate-dodecahydrate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/magnesium-citrate-dodecahydrate\/","title":{"rendered":"Magnesium Citrate Dodecahydrate"},"content":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n

General Notices (Ph. Eur. monograph 2401)<\/p>\n

\"magnesium-chloride-hexahydrate-1\"<\/p>\n

Mg3<\/sub>(C6<\/sub>H5<\/sub>O7<\/sub>)2<\/sub>,xH2<\/sub>O with x ~ 12 451.1 (anhydrous substance)<\/p>\n

DEFINITION<\/h2>\n

Trimagnesium bis(2-hydroxypropane-1,2,3-tricarboxylate) dodecahydrate.<\/p>\n

Content<\/h3>\n

15.0 per cent to 16.5 per cent of Mg (dried substance).<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

White or almost white, fine powder.<\/p>\n

Solubility<\/h3>\n

Sparingly soluble in water, practically insoluble in ethanol (96 per cent). It dissolves in dilute hydrochloric acid.<\/p>\n

IDENTIFICATION<\/h2>\n

A. It gives the reaction of citrates (2.3.1).<\/p>\n

B. It gives the reaction of magnesium (2.3.1).<\/p>\n

C. Loss on drying (see Tests).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\n

Dissolve 2.5 g in 15 mL of dilute hydrochloric acid R with heating. Cool and dilute to 100 mL with distilled water R.<\/p>\n

Appearance of solution<\/h3>\n

Solution S is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).<\/p>\n

pH (2.2.3)<\/h3>\n

6.0 to 8.5.<\/p>\n

Disperse 5.0 g in carbon dioxide-free water R and dilute to 100 mL with the same solvent. Centrifuge and measure the pH of the clear supernatant.<\/p>\n

Oxalates<\/h3>\n

Maximum 280 ppm.<\/p>\n

Dissolve 0.50 g in a mixture of 3 mL of hydrochloric acid R and 4 mL of water R and add 1 g of activated zinc R. Allow to stand for 5 min. Transfer the liquid to a tube containing 0.25 mL of a 10 g\/L solution of phenylhydrazine hydrochloride R. Heat to boiling. Cool rapidly, transfer to a graduated cylinder and add an equal volume of hydrochloric acid R and 0.25 mL of potassium ferricyanide solution R. Shake and allow to stand for 30 min. Any pink colour in the solution is not more intense than that of a standard prepared at the same time and in the same manner using 4 mL of a 50 mg\/L solution of oxalic acid R.<\/p>\n

Sulfates (2.4.13)<\/h3>\n

Maximum 0.2 per cent.<\/p>\n

Dilute 3.0 mL of solution S to 15 mL with distilled water R.<\/p>\n

Calcium (2.4.3)<\/h3>\n

Maximum 0.2 per cent.<\/p>\n

To a mixture of 2 mL of solution S and 8 mL of distilled water R, add about 0.2 mL of ammonia R and dilute to 15 mL with distilled water R.<\/p>\n

Iron (2.4.9)<\/h3>\n

Maximum 100 ppm.<\/p>\n

Dilute 4.0 mL of solution S to 10 mL with distilled water R.<\/p>\n

Loss on drying (2.2.32)<\/h3>\n

29.0 per cent to 36.0 per cent, determined on 1.000 g by drying in an oven at 180 \u00b1 10 \u00b0C for 5 h.<\/p>\n

ASSAY<\/h2>\n

Dissolve 0.200 g in 5 mL of dilute hydrochloric acid R with heating. Cool and add 50 mL of water R. Adjust to pH 7.0 with ammonia R. Carry out the complexometric titration of magnesium (2.5.11).<\/p>\n

1 mL of 0.1 M sodium edetate is equivalent to 2.431 mg of Mg.<\/p>\n","protected":false},"excerpt":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update) General Notices (Ph. Eur. monograph 2401) Mg3(C6H5O7)2,xH2O with x ~ 12 451.1 (anhydrous substance) DEFINITION Trimagnesium bis(2-hydroxypropane-1,2,3-tricarboxylate) dodecahydrate. Content 15.0 per cent to 16.5 per cent of Mg (dried substance). CHARACTERS Appearance White or almost white, fine powder. Solubility Sparingly soluble in water, practically insoluble in ethanol (96…<\/p>\n","protected":false},"author":5,"featured_media":23667,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-23657","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23657","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=23657"}],"version-history":[{"count":3,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23657\/revisions"}],"predecessor-version":[{"id":23672,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23657\/revisions\/23672"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/23667"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=23657"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=23657"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=23657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}