{"id":23607,"date":"2025-11-01T01:47:47","date_gmt":"2025-10-31T18:47:47","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=23607"},"modified":"2025-11-01T01:48:04","modified_gmt":"2025-10-31T18:48:04","slug":"medroxyprogesterone-acetate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/medroxyprogesterone-acetate\/","title":{"rendered":"Medroxyprogesterone Acetate"},"content":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n<p>General Notices<\/p>\n<p>(Ph. Eur. monograph 0673)<\/p>\n<p>C<sub>24<\/sub>H<sub>34<\/sub>O<sub>4<\/sub> 386.5 71-58-9<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Progestogen.<\/p>\n<p><strong>Preparations<\/strong><\/p>\n<p>Medroxyprogesterone Injection<\/p>\n<p>Medroxyprogesterone Tablets<\/p>\n<h2>DEFINITION<\/h2>\n<p>6\u03b1-Methyl-3,20-dioxopregn-4-en-17-yl acetate.<\/p>\n<p><strong>Content<\/strong><\/p>\n<p>97.0 per cent to 103.0 per cent (dried substance).<\/p>\n<h2>CHARACTERS<\/h2>\n<p><strong>Appearance<\/strong><\/p>\n<p>White or almost white, crystalline powder.<\/p>\n<p><strong>Solubility<\/strong><\/p>\n<p>Practically insoluble in water, freely soluble in methylene chloride, soluble in acetone, sparingly soluble in<br \/>\nethanol (96 per cent).<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison medroxyprogesterone acetate CRS.<\/p>\n<h2>TESTS<\/h2>\n<p>Specific optical rotation (2.2.7)<\/p>\n<p>+ 47 to + 53 (dried substance).<\/p>\n<p>Dissolve 0.250 g in acetone R and dilute to 25.0 mL with the same solvent.<\/p>\n<p><strong>Impurity F<\/strong><\/p>\n<p>Liquid chromatography (2.2.29).<\/p>\n<p>Test solution Dissolve 20 mg of the substance to be examined in 5.0 mL of acetonitrile R1 and dilute to<br \/>\n10.0 mL with water for chromatography R.<\/p>\n<p>Reference solution (a) Dilute 1.0 mL of the test solution to 20.0 mL with the mobile phase. Dilute 1.0 mL of this solution to 10.0 mL with the mobile phase.<\/p>\n<p>Reference solution (b) Dissolve 10 mg of medroxyprogesterone acetate for peak identification CRS<br \/>\n(containing impurity F) in 3.0 mL of acetonitrile R1 and dilute to 5.0 mL with water for chromatography R.<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.10 m, \u00d8 = 4.6 mm;<\/p>\n<p>\u2014 stationary phase: end-capped octadecylsilyl silica gel for chromatography R (3 \u03bcm).<\/p>\n<p>Mobile phase water for chromatography R, acetonitrile R1 (44:56 V\/V).<\/p>\n<p>Flow rate 1.0 mL\/min.<\/p>\n<p>Detection Spectrophotometer at 200 nm.<\/p>\n<p>Injection 25 \u03bcL.<\/p>\n<p>Identification of impurities Use the chromatogram supplied with medroxyprogesterone acetate for peak<br \/>\nidentification CRS and the chromatogram obtained with reference solution (b) to identify the peak due to<br \/>\nimpurity F.<\/p>\n<p>Relative retention With reference to medroxyprogesterone acetate (retention time = about 8 min):<br \/>\nimpurity F = about 1.8.<\/p>\n<p>Limit:<\/p>\n<p>\u2014 correction factor: for the calculation of content, multiply the peak area of impurity F by 1.8;<\/p>\n<p>\u2014 impurity F: not more than the area of the principal peak in the chromatogram obtained with reference<br \/>\nsolution (a) (0.5 per cent).<\/p>\n<p><strong>Related substances<\/strong><\/p>\n<p>Liquid chromatography (2.2.29).<\/p>\n<p>Solvent mixture acetonitrile R, water R (50:50 V\/V).<\/p>\n<p>Test solution Dissolve 20 mg of the substance to be examined in the solvent mixture and dilute to 10.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (a) Dissolve 4 mg of medroxyprogesterone acetate for system suitability CRS<br \/>\n(containing impurities A, B, C, D, E, G and I) in the solvent mixture and dilute to 2.0 mL with the solvent<br \/>\nmixture.<\/p>\n<p>Reference solution (b) Dilute 1.0 mL of the test solution to 100.0 mL with the solvent mixture.<\/p>\n<p>Reference solution (c) Dilute 1.0 mL of reference solution (b) to 10.0 mL with the solvent mixture.<\/p>\n<p>Column:<\/p>\n<p>\u2014 size: l = 0.25 m, \u00d8 = 3.0 mm;<\/p>\n<p>\u2014 stationary phase: end-capped octadecylsilyl silica gel for chromatography R (5 \u03bcm);<\/p>\n<p>\u2014 temperature: 60 \u00b0C.<\/p>\n<p>Mobile phase tetrahydrofuran R, acetonitrile R, water R (12:23:65 V\/V\/V).<\/p>\n<p>Flow rate 0.9 mL\/min.<\/p>\n<p>Detection Spectrophotometer at 254 nm.<\/p>\n<p>Injection 10 \u03bcL.<\/p>\n<p>Run time Twice the retention time of medroxyprogesterone acetate.<\/p>\n<p>Identification of impurities Use the chromatogram supplied with medroxyprogesterone acetate for system<br \/>\nsuitability CRS and the chromatogram obtained with reference solution (a) to identify the peaks due to<br \/>\nimpurities A, B, C, D, E, G and I.<\/p>\n<p>Relative retention With reference to medroxyprogesterone acetate (retention time = about 20 min):<\/p>\n<p>impurity A = about 0.3; impurity I = about 0.5; impurity H = about 0.65; impurity B = about 0.7;<\/p>\n<p>impurity C = about 0.8; impurity G = about 0.85; impurity D = about 0.9; impurity E = about 0.95.<\/p>\n<p>System suitability Reference solution (a):<\/p>\n<p>\u2014 peak-to-valley ratio: minimum 2.5, where Hp = height above the baseline of the peak due to impurity E and Hv = height above the baseline of the lowest point of the curve separating this peak from<br \/>\nthe peak due to medroxyprogesterone acetate.<\/p>\n<p>Limits:<\/p>\n<p>\u2014 correction factors: for the calculation of content, multiply the peak areas of the following impurities by<br \/>\nthe corresponding correction factor: impurity A = 1.5; impurity G = 2.6;<\/p>\n<p>\u2014 impurity D: not more than the area of the principal peak in the chromatogram obtained with reference<br \/>\nsolution (b) (1.0 per cent);<\/p>\n<p>\u2014 impurity B: not more than 0.7 times the area of the principal peak in the chromatogram obtained with<br \/>\nreference solution (b) (0.7 per cent);<\/p>\n<p>\u2014 impurity A: not more than 3 times the area of the principal peak in the chromatogram obtained with<br \/>\nreference solution (c) (0.3 per cent);<\/p>\n<p>\u2014 impurities C, E, G, I: for each impurity, not more than twice the area of the principal peak in the<br \/>\nchromatogram obtained with reference solution (c) (0.2 per cent);<\/p>\n<p>\u2014 unspecified impurities: for each impurity, not more than the area of the principal peak in the<br \/>\nchromatogram obtained with reference solution (c) (0.10 per cent);<\/p>\n<p>\u2014 total: not more than 1.5 times the area of the principal peak in the chromatogram obtained with<br \/>\nreference solution (b) (1.5 per cent);<\/p>\n<p>\u2014 disregard limit: 0.5 times the area of the principal peak in the chromatogram obtained with reference<br \/>\nsolution (c) (0.05 per cent).<\/p>\n<p><strong>Loss on drying (2.2.32)<\/strong><\/p>\n<p>Maximum 1.0 per cent, determined on 0.500 g by drying in an oven at 105 \u00b0C for 3 h.<\/p>\n<h2>ASSAY<\/h2>\n<p>Dissolve 50.0 mg in ethanol (96 per cent) R and dilute to 50.0 mL with the same solvent. Dilute 2.0 mL of the solution to 100.0 mL with ethanol (96 per cent) R. Measure the absorbance (2.2.25) at the absorption<br \/>\nmaximum at 241 nm.<\/p>\n<p>Calculate the content of C<sub>24<\/sub>H<sub>34<\/sub>O<sub>4<\/sub> taking the specific absorbance to be 420.<\/p>\n<h2>STORAGE<\/h2>\n<p>Protected from light.<\/p>\n<h2>IMPURITIES<\/h2>\n<p>Specified impurities A, B, C, D, E, F, G, I.<\/p>\n<p>Other detectable impurities (the following substances would, if present at a sufficient level, be detected by one or other of the tests in the monograph. They are limited by the general acceptance criterion for<br \/>\nother\/unspecified impurities and\/or by the general monograph Substances for pharmaceutical use (2034). It is therefore not necessary to identify these impurities for demonstration of compliance. See also 5.10.<br \/>\nControl of impurities in substances for pharmaceutical use) H.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-23629\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-20-dioxopregn-4-en-17-yl-acetate-hydroxyprogesterone-acetate.jpg\" alt=\"6\u03b2-hydroxy-6-methyl-3,20-dioxopregn-4-en-17-yl acetate (6-hydroxymedroxyprogesterone acetate)\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-20-dioxopregn-4-en-17-yl-acetate-hydroxyprogesterone-acetate.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-20-dioxopregn-4-en-17-yl-acetate-hydroxyprogesterone-acetate-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-20-dioxopregn-4-en-17-yl-acetate-hydroxyprogesterone-acetate-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-20-dioxopregn-4-en-17-yl-acetate-hydroxyprogesterone-acetate-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p>A. 6\u03b2-hydroxy-6-methyl-3,20-dioxopregn-4-en-17-yl acetate (6-hydroxymedroxyprogesterone acetate),<\/p>\n<div class=\"mceTemp\"><\/div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-23637\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/17-hydroxy-6\u03b1-methylpregn-4-ene-3-20-dione-medroxyprogesterone.jpg\" alt=\"17-hydroxy-6\u03b1-methylpregn-4-ene-3,20-dione (medroxyprogesterone)\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/17-hydroxy-6\u03b1-methylpregn-4-ene-3-20-dione-medroxyprogesterone.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/17-hydroxy-6\u03b1-methylpregn-4-ene-3-20-dione-medroxyprogesterone-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/17-hydroxy-6\u03b1-methylpregn-4-ene-3-20-dione-medroxyprogesterone-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/17-hydroxy-6\u03b1-methylpregn-4-ene-3-20-dione-medroxyprogesterone-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p>B. 17-hydroxy-6\u03b1-methylpregn-4-ene-3,20-dione (medroxyprogesterone),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-23632\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b1-17a-dimethyl-3-17-dioxo-D-homoandrost-4-en-17a\u03b1-yl-acetate.jpg\" alt=\"6\u03b1,17a-dimethyl-3,17-dioxo-D-homoandrost-4-en-17a\u03b1-yl acetate,\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b1-17a-dimethyl-3-17-dioxo-D-homoandrost-4-en-17a\u03b1-yl-acetate.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b1-17a-dimethyl-3-17-dioxo-D-homoandrost-4-en-17a\u03b1-yl-acetate-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b1-17a-dimethyl-3-17-dioxo-D-homoandrost-4-en-17a\u03b1-yl-acetate-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b1-17a-dimethyl-3-17-dioxo-D-homoandrost-4-en-17a\u03b1-yl-acetate-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p>C. 6\u03b1,17a-dimethyl-3,17-dioxo-D-homoandrost-4-en-17a\u03b1-yl acetate,<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-23635\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b2-methyl-3-20-dioxopregn-4-en-17-yl-acetate-6-epimedroxyprogesterone-acetate.jpg\" alt=\"6\u03b2-methyl-3,20-dioxopregn-4-en-17-yl acetate (6-epimedroxyprogesterone acetate)\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b2-methyl-3-20-dioxopregn-4-en-17-yl-acetate-6-epimedroxyprogesterone-acetate.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b2-methyl-3-20-dioxopregn-4-en-17-yl-acetate-6-epimedroxyprogesterone-acetate-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b2-methyl-3-20-dioxopregn-4-en-17-yl-acetate-6-epimedroxyprogesterone-acetate-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b2-methyl-3-20-dioxopregn-4-en-17-yl-acetate-6-epimedroxyprogesterone-acetate-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p>D. 6\u03b2-methyl-3,20-dioxopregn-4-en-17-yl acetate (6-epimedroxyprogesterone acetate),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-23631\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-methylidene-3-20-dioxopregn-4-en-17-yl-acetate-6-methylenehydroxyprogesterone-acetate.jpg\" alt=\"6-methylidene-3,20-dioxopregn-4-en-17-yl acetate (6-methylenehydroxyprogesterone acetate)\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-methylidene-3-20-dioxopregn-4-en-17-yl-acetate-6-methylenehydroxyprogesterone-acetate.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-methylidene-3-20-dioxopregn-4-en-17-yl-acetate-6-methylenehydroxyprogesterone-acetate-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-methylidene-3-20-dioxopregn-4-en-17-yl-acetate-6-methylenehydroxyprogesterone-acetate-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-methylidene-3-20-dioxopregn-4-en-17-yl-acetate-6-methylenehydroxyprogesterone-acetate-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p>E. 6-methylidene-3,20-dioxopregn-4-en-17-yl acetate (6-methylenehydroxyprogesterone acetate),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-23633\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b1-methyl-3-20-dioxo-5\u03b2-pregnan-17-yl-acetate-4-5-dihydromedroxyprogesterone-acetate.jpg\" alt=\"6\u03b1-methyl-3,20-dioxo-5\u03b2-pregnan-17-yl acetate (4,5-dihydromedroxyprogesterone acetate)\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b1-methyl-3-20-dioxo-5\u03b2-pregnan-17-yl-acetate-4-5-dihydromedroxyprogesterone-acetate.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b1-methyl-3-20-dioxo-5\u03b2-pregnan-17-yl-acetate-4-5-dihydromedroxyprogesterone-acetate-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b1-methyl-3-20-dioxo-5\u03b2-pregnan-17-yl-acetate-4-5-dihydromedroxyprogesterone-acetate-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6\u03b1-methyl-3-20-dioxo-5\u03b2-pregnan-17-yl-acetate-4-5-dihydromedroxyprogesterone-acetate-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p>F. 6\u03b1-methyl-3,20-dioxo-5\u03b2-pregnan-17-yl acetate (4,5-dihydromedroxyprogesterone acetate),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-23630\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-methyl-3-20-dioxopregna-4-6-dien-17-yl-acetate-megestrol-acetate.jpg\" alt=\"6-methyl-3,20-dioxopregna-4,6-dien-17-yl acetate (megestrol acetate)\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-methyl-3-20-dioxopregna-4-6-dien-17-yl-acetate-megestrol-acetate.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-methyl-3-20-dioxopregna-4-6-dien-17-yl-acetate-megestrol-acetate-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-methyl-3-20-dioxopregna-4-6-dien-17-yl-acetate-megestrol-acetate-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/6-methyl-3-20-dioxopregna-4-6-dien-17-yl-acetate-megestrol-acetate-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p>G. 6-methyl-3,20-dioxopregna-4,6-dien-17-yl acetate (megestrol acetate),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-23629\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-20-dioxopregn-4-en-17-yl-acetate-hydroxyprogesterone-acetate.jpg\" alt=\"3,20-dioxopregn-4-en-17-yl acetate (hydroxyprogesterone acetate)\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-20-dioxopregn-4-en-17-yl-acetate-hydroxyprogesterone-acetate.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-20-dioxopregn-4-en-17-yl-acetate-hydroxyprogesterone-acetate-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-20-dioxopregn-4-en-17-yl-acetate-hydroxyprogesterone-acetate-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/3-20-dioxopregn-4-en-17-yl-acetate-hydroxyprogesterone-acetate-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p>H. 3,20-dioxopregn-4-en-17-yl acetate (hydroxyprogesterone acetate),<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-23636\" src=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/17a\u03b2-hydroxy-6-17a-dimethyl-D-homoandrost-4-ene-3-17-dione.jpg\" alt=\"17a\u03b2-hydroxy-6,17a-dimethyl-D-homoandrost-4-ene-3,17-dione\" width=\"1200\" height=\"650\" srcset=\"https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/17a\u03b2-hydroxy-6-17a-dimethyl-D-homoandrost-4-ene-3-17-dione.jpg 1200w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/17a\u03b2-hydroxy-6-17a-dimethyl-D-homoandrost-4-ene-3-17-dione-300x163.jpg 300w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/17a\u03b2-hydroxy-6-17a-dimethyl-D-homoandrost-4-ene-3-17-dione-1024x555.jpg 1024w, https:\/\/nhathuocngocanh.com\/bp\/wp-content\/uploads\/2025\/11\/17a\u03b2-hydroxy-6-17a-dimethyl-D-homoandrost-4-ene-3-17-dione-768x416.jpg 768w\" sizes=\"auto, (max-width: 1200px) 100vw, 1200px\" \/><\/p>\n<p>I. 17a\u03b2-hydroxy-6,17a-dimethyl-D-homoandrost-4-ene-3,17-dione.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update) General Notices (Ph. Eur. monograph 0673) C24H34O4 386.5 71-58-9 Action and use Progestogen. Preparations Medroxyprogesterone Injection Medroxyprogesterone Tablets DEFINITION 6\u03b1-Methyl-3,20-dioxopregn-4-en-17-yl acetate. Content 97.0 per cent to 103.0 per cent (dried substance). CHARACTERS Appearance White or almost white, crystalline powder. Solubility Practically insoluble in water, freely soluble in methylene&#8230;<\/p>\n","protected":false},"author":5,"featured_media":23565,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-23607","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=23607"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23607\/revisions"}],"predecessor-version":[{"id":23639,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23607\/revisions\/23639"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/23565"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=23607"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=23607"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=23607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}