(Ph. Eur. monograph 1443)<\/p>\n
Action and use<\/strong> Mixture of mainly mono- and diesters of polyoxyethylene glycerol ethers mainly with caprylic (octanoic) and capric (decanoic) acids. The average number of moles of ethylene oxide reacted per mole of substance is 6.<\/p>\n Macrogol 6 glycerol caprylocaprate may be obtained by ethoxylation of glycerol and esterification with distilled coconut or palm kernel fatty acids, or by ethoxylation of mono- and diglycerides of caprylic and capric acids.<\/p>\n Appearance<\/strong> Solubility<\/strong> Viscosity<\/strong> A. Dissolve 1.0 g in 99 g of a mixture of 10 volumes of 2-propanol R and 90 volumes of water R. Heat the solution obtained to about 40 \u00b0C. A turbidity is produced. Allow to cool until the turbidity disappears. The cloud point is between 15 \u00b0C and 35 \u00b0C.<\/p>\n B. Saponification value (see Tests).<\/p>\n C. Composition of fatty acids (see Tests).<\/p>\n Appearance<\/strong> Alkalinity<\/strong> Acid value (2.5.1)<\/strong> Hydroxyl value (2.5.3, Method A)<\/strong> Saponification value (2.5.6)<\/strong> Composition of fatty acids<\/strong> Composition of the fatty-acid fraction of the substance:<\/p>\n caproic acid: maximum 2.0 per cent;<\/p>\n caprylic acid: 50.0 per cent to 80.0 per cent;<\/p>\n capric acid: 20.0 per cent to 50.0 per cent;<\/p>\n lauric acid: maximum 3.0 per cent;<\/p>\n myristic acid: maximum 1.0 per cent.<\/p>\n Ethylene oxide and dioxan (2.4.25)<\/strong> Water (2.5.12)<\/strong> Total ash (2.4.16)<\/strong><\/p>\n Maximum 0.3 per cent.<\/p>\n","protected":false},"excerpt":{"rendered":" (Ph. Eur. monograph 1443) Action and use Non-ionic surfactant. DEFINITION Mixture of mainly mono- and diesters of polyoxyethylene glycerol ethers mainly with caprylic (octanoic) and capric (decanoic) acids. The average number of moles of ethylene oxide reacted per mole of substance is 6. Macrogol 6 glycerol caprylocaprate may be obtained by ethoxylation of glycerol and…<\/p>\n","protected":false},"author":5,"featured_media":23192,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-23189","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23189","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=23189"}],"version-history":[{"count":1,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23189\/revisions"}],"predecessor-version":[{"id":23196,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23189\/revisions\/23196"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/23192"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=23189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=23189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=23189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nNon-ionic surfactant.<\/p>\nDEFINITION<\/h2>\n
CHARACTERS<\/h2>\n
\nPale yellow liquid.<\/p>\n
\nPartly soluble in water, freely soluble in castor oil, in glycerol, in isopropanol and in propylene glycol.<\/p>\n
\nAbout 145 mPa\u00b7s.<\/p>\nIDENTIFICATION<\/h2>\n
TESTS<\/h2>\n
\nThe substance to be examined is clear (2.2.1) and not more intensely coloured than reference solution Y2 (2.2.2, Method I).<\/p>\n
\nDissolve 2.0 g in a hot mixture of 10 mL of ethanol (96 per cent) R and 10 mL of water R. Add 0.1 mL of bromothymol blue solution R1. Not more than 0.5 mL of 0.1 M hydrochloric acid is required to change the colour of the indicator to yellow.<\/p>\n
\nMaximum 5.0, determined on 5.0 g.<\/p>\n
\n165 to 225.<\/p>\n
\n85 to 105, determined on 2.0 g.<\/p>\n
\nGas chromatography (2.4.22, Method A).<\/p>\n
\nMaximum 1 ppm of ethylene oxide and maximum 10 ppm of dioxan.<\/p>\n
\nMaximum 1.0 per cent, determined on 1.00 g.<\/p>\n