{"id":23179,"date":"2025-10-31T14:29:56","date_gmt":"2025-10-31T07:29:56","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=23179"},"modified":"2025-10-31T14:36:22","modified_gmt":"2025-10-31T07:36:22","slug":"magnesium-lactate-dihydrate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/magnesium-lactate-dihydrate\/","title":{"rendered":"Magnesium Lactate Dihydrate"},"content":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n

C_{6<\/sub>H_{10<\/sub>MgO_{6<\/sub>,2H_{2<\/sub>O 238.5<\/p>\n}}}}

DEFINITION<\/h2>\n
Magnesium bis(2-hydroxypropanoate) or mixture of magnesium (2R)-, (2S)- and (2RS)-2- hydroxypropanoate dihydrate.<\/p>\n
Content<\/strong><\/p>\n
98.0 per cent to 102.0 per cent (dried substance).<\/p>\n

CHARACTERS<\/h2>\n
Appearance<\/h3>\n
White or almost white, crystalline or granular powder.<\/p>\n
Solubility<\/h3>\n
Slightly soluble in water, soluble in boiling water, practically insoluble in ethanol (96 per cent).<\/p>\n
IDENTIFICATION<\/h2>\n
A. It gives the reaction of lactates (2.3.1).<\/p>\n
B. It gives the reaction of magnesium (2.3.1).<\/p>\n
TESTS<\/h2>\n
Solution S<\/h3>\n
Dissolve 5.0 g with heating in carbon dioxide-free water R prepared from distilled water R, allow to cool and
\ndilute to 100 mL with the same solvent.<\/p>\n
Appearance of solution<\/h3>\n
Solution S is not more opalescent than reference suspension II (2.2.1) and not more intensely coloured than
\nreference solution BY_{6<\/sub> (2.2.2, Method II).<\/p>\n}
pH (2.2.3)<\/h3>\n
6.5 to 8.5 for solution S.<\/p>\n
Chlorides (2.4.4)<\/h3>\n
Maximum 200 ppm.<\/p>\n
Dilute 5 mL of solution S to 15 mL with water R.<\/p>\n
Sulfates (2.4.13)<\/h3>\n
Maximum 400 ppm.<\/p>\n
Dilute 7.5 mL of solution S to 15 mL with distilled water R.<\/p>\n
Iron (2.4.9)<\/h3>\n
Maximum 50 ppm.<\/p>\n
Dilute 4 mL of solution S to 10 mL with water R.<\/p>\n
Loss on drying (2.2.32)<\/h3>\n
14.0 per cent to 17.0 per cent, determined on 0.500 g by drying in an oven at 125 \u00b0C.<\/p>\n
ASSAY<\/h2>\n
Dissolve 0.180 g in water R and dilute to 300 mL with the same solvent. Carry out the complexometric titration of magnesium (2.5.11).<\/p>\n
1 mL of 0.1 M sodium edetate is equivalent to 20.25 mg of C_{6<\/sub>H_{10<\/sub>MgO_{6<\/sub><\/p>\n","protected":false},"excerpt":{"rendered":"}}}
Edition: BP 2025 (Ph. Eur. 11.6 update) C6H10MgO6,2H2O 238.5 DEFINITION Magnesium bis(2-hydroxypropanoate) or mixture of magnesium (2R)-, (2S)- and (2RS)-2- hydroxypropanoate dihydrate. Content 98.0 per cent to 102.0 per cent (dried substance). CHARACTERS Appearance White or almost white, crystalline or granular powder. Solubility Slightly soluble in water, soluble in boiling water, practically insoluble in ethanol…<\/p>\n","protected":false},"author":5,"featured_media":23185,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-23179","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=23179"}],"version-history":[{"count":3,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23179\/revisions"}],"predecessor-version":[{"id":23195,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/23179\/revisions\/23195"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/23185"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=23179"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=23179"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=23179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

DEFINITION<\/h2>\nMagnesium bis(2-hydroxypropanoate) or mixture of magnesium (2R)-, (2S)- and (2RS)-2- hydroxypropanoate dihydrate.<\/p>\nContent<\/strong><\/p>\n98.0 per cent to 102.0 per cent (dried substance).<\/p>\n

Appearance<\/h3>\nWhite or almost white, crystalline or granular powder.<\/p>\n

Solubility<\/h3>\nSlightly soluble in water, soluble in boiling water, practically insoluble in ethanol (96 per cent).<\/p>\n

IDENTIFICATION<\/h2>\nA. It gives the reaction of lactates (2.3.1).<\/p>\nB. It gives the reaction of magnesium (2.3.1).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\nDissolve 5.0 g with heating in carbon dioxide-free water R prepared from distilled water R, allow to cool and\ndilute to 100 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\nSolution S is not more opalescent than reference suspension II (2.2.1) and not more intensely coloured than\nreference solution BY6<\/sub> (2.2.2, Method II).<\/p>\n

pH (2.2.3)<\/h3>\n6.5 to 8.5 for solution S.<\/p>\n

Chlorides (2.4.4)<\/h3>\nMaximum 200 ppm.<\/p>\nDilute 5 mL of solution S to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\nMaximum 400 ppm.<\/p>\nDilute 7.5 mL of solution S to 15 mL with distilled water R.<\/p>\n

Iron (2.4.9)<\/h3>\nMaximum 50 ppm.<\/p>\nDilute 4 mL of solution S to 10 mL with water R.<\/p>\n

Loss on drying (2.2.32)<\/h3>\n14.0 per cent to 17.0 per cent, determined on 0.500 g by drying in an oven at 125 \u00b0C.<\/p>\n

DEFINITION<\/h2>\n
Magnesium bis(2-hydroxypropanoate) or mixture of magnesium (2R)-, (2S)- and (2RS)-2- hydroxypropanoate dihydrate.<\/p>\n
Content<\/strong><\/p>\n
98.0 per cent to 102.0 per cent (dried substance).<\/p>\n

Appearance<\/h3>\n
White or almost white, crystalline or granular powder.<\/p>\n

Solubility<\/h3>\n
Slightly soluble in water, soluble in boiling water, practically insoluble in ethanol (96 per cent).<\/p>\n

IDENTIFICATION<\/h2>\n
A. It gives the reaction of lactates (2.3.1).<\/p>\n
B. It gives the reaction of magnesium (2.3.1).<\/p>\n

Solution S<\/h3>\n
Dissolve 5.0 g with heating in carbon dioxide-free water R prepared from distilled water R, allow to cool and
\ndilute to 100 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\n
Solution S is not more opalescent than reference suspension II (2.2.1) and not more intensely coloured than
\nreference solution BY_{6<\/sub> (2.2.2, Method II).<\/p>\n}

pH (2.2.3)<\/h3>\n
6.5 to 8.5 for solution S.<\/p>\n

Chlorides (2.4.4)<\/h3>\n
Maximum 200 ppm.<\/p>\n
Dilute 5 mL of solution S to 15 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\n
Maximum 400 ppm.<\/p>\n
Dilute 7.5 mL of solution S to 15 mL with distilled water R.<\/p>\n

Iron (2.4.9)<\/h3>\n
Maximum 50 ppm.<\/p>\n
Dilute 4 mL of solution S to 10 mL with water R.<\/p>\n

Loss on drying (2.2.32)<\/h3>\n
14.0 per cent to 17.0 per cent, determined on 0.500 g by drying in an oven at 125 \u00b0C.<\/p>\n