{"id":22950,"date":"2025-10-31T08:30:38","date_gmt":"2025-10-31T01:30:38","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=22950"},"modified":"2025-11-10T22:34:38","modified_gmt":"2025-11-10T15:34:38","slug":"magnesium-glycerophosphate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/magnesium-glycerophosphate\/","title":{"rendered":"Magnesium Glycerophosphate"},"content":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n

\"Magnesium<\/p>\n

(Ph. Eur. monograph 1446)<\/p>\n

C3<\/sub>H7<\/sub>MgO6<\/sub>P\u00a0 \u00a0 \u00a0194.4<\/p>\n

Action and use<\/strong><\/p>\n

Excipient.<\/p>\n

Preparations<\/strong><\/p>\n

Magnesium Glycerophosphate Chewable Tablets<\/p>\n

Magnesium Glycerophosphate Oral Solution<\/p>\n

Ph Eur<\/p>\n

DEFINITION<\/h2>\n

Mixture, in variable proportions, of magnesium salts of (RS)-2,3-dihydroxypropyl phosphate and 2-hydroxy-1-(hydroxymethyl)ethyl phosphate, which may be hydrated.<\/p>\n

Content<\/strong><\/p>\n

11.0 per cent to 12.5 per cent of Mg (dried substance).<\/p>\n

CHARACTERS<\/h2>\n

Appearance<\/h3>\n

White or almost white powder, hygroscopic.<\/p>\n

Solubility<\/h3>\n

Practically insoluble in ethanol (96 per cent). It dissolves in dilute solutions of acids.<\/p>\n

IDENTIFICATION<\/h2>\n

A. Mix 1 g with 1 g of potassium hydrogen sulfate R in a test tube fitted with a glass tube. Heat strongly and direct the white vapour towards a piece of filter paper impregnated with a freshly prepared 10 g\/L solution of sodium nitroprusside R. The filter paper develops a blue colour in contact with piperidine R.<\/p>\n

B. Ignite 0.1 g in a crucible. Take up the residue with 5 mL of nitric acid R and heat on a water-bath for 1 min. Filter. The filtrate gives reaction (b) of phosphates (2.3.1).<\/p>\n

C. It gives the reaction of magnesium (2.3.1).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\n

Dissolve 2.5 g in carbon dioxide-free water R prepared from distilled water R and dilute to 50 mL with the same solvent.<\/p>\n

Appearance of solution<\/h3>\n

Solution S is not more opalescent than reference suspension III (2.2.1).<\/p>\n

Acidity<\/h3>\n

Dissolve 1.0 g in 100 mL of carbon dioxide-free water R. Add 0.1 mL of phenolphthalein solution R. Not more than 1.5 mL of 0.1 M sodium hydroxide is required to change the colour of the indicator.<\/p>\n

Glycerol and ethanol (96 per cent)-soluble substances<\/h3>\n

Maximum 1.5 per cent.<\/p>\n

Shake 1.0 g with 25 mL of ethanol (96 per cent) R for 2 min. Filter and wash the residue with 5 mL of ethanol (96 per cent) R. Combine the filtrate and the washings, evaporate to dryness on a water-bath and dry the residue at 70 \u00b0C for 1 h. The residue weighs a maximum of 15 mg.<\/p>\n

Chlorides (2.4.4)<\/h3>\n

Maximum 0.15 per cent.<\/p>\n

Dissolve 1.0 g in water R and dilute to 100 mL with the same solvent. Dilute 3.5 mL of this solution to 15 mL with water R.<\/p>\n

Phosphates (2.4.11)<\/h3>\n

Maximum 0.5 per cent.<\/p>\n

Dilute 4 mL of solution S to 100 mL with water R. Dilute 1 mL of this solution to 100 mL with water R.<\/p>\n

Sulfates (2.4.13)<\/h3>\n

Maximum 0.1 per cent.<\/p>\n

Dilute 3 mL of solution S to 15 mL with distilled water R.<\/p>\n

Iron (2.4.9)<\/h3>\n

Maximum 150 ppm.<\/p>\n

Dissolve 67 mg in water R and dilute to 10 mL with the same solvent.<\/p>\n

Loss on drying (2.2.32)<\/h3>\n

Maximum 12.0 per cent, determined on 1.000 g by drying in an oven at 150 \u00b0C for 4 h.<\/p>\n

ASSAY<\/h2>\n

Dissolve 0.200 g in 40 mL of water R. Carry out the complexometric titration of magnesium (2.5.11).<\/p>\n

1 mL of 0.1 M sodium edetate is equivalent to 2.431 mg of Mg.<\/p>\n

STORAGE<\/h2>\n

In an airtight container.<\/p>\n

Ph Eur<\/p>\n","protected":false},"excerpt":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update) (Ph. Eur. monograph 1446) C3H7MgO6P\u00a0 \u00a0 \u00a0194.4 Action and use Excipient. Preparations Magnesium Glycerophosphate Chewable Tablets Magnesium Glycerophosphate Oral Solution Ph Eur DEFINITION Mixture, in variable proportions, of magnesium salts of (RS)-2,3-dihydroxypropyl phosphate and 2-hydroxy-1-(hydroxymethyl)ethyl phosphate, which may be hydrated. Content 11.0 per cent to 12.5 per cent…<\/p>\n","protected":false},"author":5,"featured_media":22953,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-22950","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22950","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=22950"}],"version-history":[{"count":4,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22950\/revisions"}],"predecessor-version":[{"id":29692,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22950\/revisions\/29692"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/22953"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=22950"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=22950"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=22950"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}