{"id":22844,"date":"2025-10-30T17:14:21","date_gmt":"2025-10-30T10:14:21","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=22844"},"modified":"2025-10-30T17:14:21","modified_gmt":"2025-10-30T10:14:21","slug":"calcium-copperedetate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/calcium-copperedetate\/","title":{"rendered":"Calcium Copperedetate"},"content":{"rendered":"<p>C<sub>10<\/sub>H<sub>12<\/sub>CaCuN<sub>2<\/sub>O<sub>8<\/sub>,2H<sub>2<\/sub>O\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 427.6<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Used in the treatment of copper deficiency.<\/p>\n<p><strong>Preparation<\/strong><\/p>\n<p>Calcium Copperedetate Injection<\/p>\n<h2>DEFINITION<\/h2>\n<p>Calcium Copperedetate is the dihydrate of calcium [ethylenediaminetetra-acetato(4-)-N,N\u2032,O,O\u2032]copper(II). It contains not less than 9.1% and not more than 9.7% of calcium, Ca, and not less than 14.4% and not more than 15.3% of copper, Cu, both calculated with reference to the dried substance.<\/p>\n<h2>CHARACTERISTICS<\/h2>\n<p>A blue, crystalline powder.<\/p>\n<p>Freely soluble in water, the solution gradually precipitating the tetrahydrate; practically insoluble in ethanol (96%).<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. Dissolve 0.2 g in 5 mL of water and add 1 mL of 6M acetic acid and 2 mL of dilute potassium iodide solution. The solution remains clear and deep blue.<\/p>\n<p>B. Ignite 0.2 g, dissolve the residue in 3 mL of 2M hydrochloric acid, neutralise the solution with 5M ammonia and add 1 mL of 6M acetic acid and 2 mL of dilute potassium iodide solution. A white precipitate is produced and iodine is liberated, colouring the supernatant liquid brown.<\/p>\n<p>C. Dissolve 0.5 g in 10 mL of water, acidify with 2M hydrochloric acid, add 25 mL of a 10% v\/v solution of mercaptoacetic acid and filter. Make the filtrate alkaline with 5M ammonia and add 5 mL of a 2.5% w\/v solution of ammonium oxalate. A white precipitate is produced which is soluble in hydrochloric acid but only sparingly soluble in 6M acetic acid.<\/p>\n<h2>TESTS<\/h2>\n<h3>Lead<\/h3>\n<p>Not more than 25 ppm of Pb when determined by the following method. Dissolve 1.25 g in 10 mL of hydrochloric acid, dilute to 25 mL with water and determine by atomic absorption spectrophotometry, Appendix II D, measuring at 283.3 nm and using a lead hollow-cathode lamp as the radiation source and lead standard solution (100 ppm Pb), diluted if necessary with water, to prepare the standard solutions.<\/p>\n<h4>Zinc<\/h4>\n<p>Not more than 200 ppm of Zn when determined by the following method. Dissolve 1.0 g in 20 mL of hydrochloric acid, dilute to 200 mL with water and determine by atomic absorption spectrophotometry, Appendix II D, measuring at 213.9 nm and using a zinc hollow-cathode lamp as the radiation source and zinc standard solution (5 mg\/mL Zn) diluted if necessary with water, to prepare the standard solutions.<\/p>\n<h4>Loss on drying<\/h4>\n<p>When dried to constant weight at 105\u00b0, loses not more than 2.0% of its weight. Use 1 g.<\/p>\n<h2>ASSAY<\/h2>\n<h3>For copper<\/h3>\n<p>Ignite 4 g at 600\u00b0 to 700\u00b0, cool and heat the residue with 12 mL of a mixture of equal volumes of hydrochloric acid and water on a water bath for 15 minutes. Add 10 mL of water, filter and dilute the filtrate to 100 mL with water (solution A); reserve a portion for the Assay for calcium. To 25 mL of solution A add 25 mL of water and 10 mL of bromine solution, boil to remove the bromine, cool and add dilute sodium carbonate solution until a faint permanent precipitate is produced. Add 3 g of potassium iodide and 5 mL of 6M acetic acid and titrate the liberated iodine with 0.1M sodium thiosulfate VS, using starch mucilage as indicator, until only a faint blue colour remains; add 2 g of potassium thiocyanate and continue the titration until the blue colour disappears. Each mL of 0.1M sodium thiosulfate VS is equivalent to 6.354 mg of Cu.<\/p>\n<h3>For calcium<\/h3>\n<p>To 5 mL of solution A add 10 mL of water and 10 mL of a 10% v\/v solution of mercaptoacetic acid, allow to stand until the precipitate has coagulated, dilute to 100 mL with water, add 5 mL of 5M sodium hydroxide and titrate with 0.05M disodium edetate VS, using methyl thymol blue mixture as indicator, until the solution becomes a full purple colour, adding the titrant slowly as the end point is approached. Each mL of 0.05M disodium edetate VS is equivalent to 2.004 mg of Ca.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>C10H12CaCuN2O8,2H2O\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 427.6 Action and use Used in the treatment of copper deficiency. Preparation Calcium Copperedetate Injection DEFINITION Calcium Copperedetate is the dihydrate of calcium [ethylenediaminetetra-acetato(4-)-N,N\u2032,O,O\u2032]copper(II). It contains not less than 9.1% and not more than 9.7% of calcium, Ca, and not less than 14.4% and not more than 15.3% of copper,&#8230;<\/p>\n","protected":false},"author":2,"featured_media":22856,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[176],"tags":[],"class_list":["post-22844","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-british-pharmacopoeia-veterinary-2020"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22844","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=22844"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22844\/revisions"}],"predecessor-version":[{"id":22858,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22844\/revisions\/22858"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/22856"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=22844"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=22844"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=22844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}