{"id":22713,"date":"2025-10-30T16:31:01","date_gmt":"2025-10-30T09:31:01","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=22713"},"modified":"2025-10-30T16:35:42","modified_gmt":"2025-10-30T09:35:42","slug":"magnesium-citrate-nonahydrate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/magnesium-citrate-nonahydrate\/","title":{"rendered":"Magnesium Citrate Nonahydrate"},"content":{"rendered":"

Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n

$\"Magnesium$ <\/p>\n

Mg_{3<\/sub>(C_{6<\/sub>H_{5<\/sub>O_{7<\/sub>)_{2<\/sub>,9H2O\u00a0 613\u00a0 153531-96-5<\/p>\n}}}}}

Ph Eur<\/p>\n

DEFINITION<\/h2>\n
Trimagnesium bis(2-hydroxypropane-1,2,3-tricarboxylate) nonahydrate.<\/p>\n
Content<\/strong><\/p>\n
15.0 per cent to 16.5 per cent of Mg (dried substance).<\/p>\n

CHARACTERS<\/h2>\n
Appearance<\/h3>\n
White or almost white, fine powder.<\/p>\n
Solubility<\/h3>\n
Sparingly soluble in water, practically insoluble in ethanol (96 per cent). It dissolves in dilute hydrochloric<\/p>\n
acid.<\/p>\n
IDENTIFICATION<\/h2>\n
A. It gives the reaction of citrates (2.3.1).<\/p>\n
B. It gives the reaction of magnesium (2.3.1).<\/p>\n
C. Loss on drying (see Tests).<\/p>\n
TESTS<\/h2>\n
Solution S<\/h3>\n
Dissolve 2.5 g in 15 mL of dilute hydrochloric acid R with heating. Cool and dilute to 100 mL with distilled<\/p>\n
water R.<\/p>\n
Appearance of solution<\/h3>\n
Solution S is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).<\/p>\n
pH (2.2.3)<\/h3>\n
6.0 to 8.5.<\/p>\n
Disperse 5.0 g in carbon dioxide-free water R and dilute to 100 mL with the same solvent. Centrifuge and measure the pH of the clear supernatant.<\/p>\n
Oxalates<\/h3>\n
Maximum 280 ppm.<\/p>\n
Dissolve 0.50 g in a mixture of 3 mL of hydrochloric acid R and 4 mL of water R and add 1 g of activated zinc R. Allow to stand for 5 min. Transfer the liquid to a tube containing 0.25 mL of a 10 g\/L solution of phenylhydrazine hydrochloride R. Heat to boiling. Cool rapidly, transfer to a graduated cylinder and add an equal volume of hydrochloric acid R and 0.25 mL of potassium ferricyanide solution R. Shake and allow to stand for 30 min. Any pink colour in the solution is not more intense than that of a standard prepared at the same time and in the same manner using 4 mL of a 50 mg\/L solution of oxalic acid R.<\/p>\n
Sulfates (2.4.13)<\/h3>\n
Maximum 0.2 per cent.<\/p>\n
Dilute 3.0 mL of solution S to 15 mL with distilled water R.<\/p>\n
Calcium (2.4.3)<\/h3>\n
Maximum 0.2 per cent.<\/p>\n
To a mixture of 2 mL of solution S and 8 mL of distilled water R, add about 0.2 mL of ammonia R and dilute to 15 mL with distilled water R.<\/p>\n
Iron (2.4.9)<\/h3>\n
Maximum 100 ppm.<\/p>\n
Dilute 4.0 mL of solution S to 10 mL with distilled water R.<\/p>\n
Loss on drying (2.2.32)<\/h3>\n
24.0 to 28.0 per cent, determined on 1.000 g by drying in an oven at 180 \u00b1 10 \u00b0C for 5 h.<\/p>\n
ASSAY<\/h2>\n
Dissolve 0.200 g in 5 mL of dilute hydrochloric acid R with heating. Cool and add 50 mL of water R. Adjust to pH 7.0 with ammonia R. Carry out the complexometric titration of magnesium (2.5.11). 1 mL of 0.1 M sodium edetate is equivalent to 2.431 mg of Mg.<\/p>\n
Ph Eur<\/p>\n","protected":false},"excerpt":{"rendered":"
Edition: BP 2025 (Ph. Eur. 11.6 update) Mg3(C6H5O7)2,9H2O\u00a0 613\u00a0 153531-96-5 Ph Eur DEFINITION Trimagnesium bis(2-hydroxypropane-1,2,3-tricarboxylate) nonahydrate. Content 15.0 per cent to 16.5 per cent of Mg (dried substance). CHARACTERS Appearance White or almost white, fine powder. Solubility Sparingly soluble in water, practically insoluble in ethanol (96 per cent). It dissolves in dilute hydrochloric acid. IDENTIFICATION…<\/p>\n","protected":false},"author":5,"featured_media":22736,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-22713","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=22713"}],"version-history":[{"count":3,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22713\/revisions"}],"predecessor-version":[{"id":22769,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22713\/revisions\/22769"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/22736"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=22713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=22713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=22713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

DEFINITION<\/h2>\nTrimagnesium bis(2-hydroxypropane-1,2,3-tricarboxylate) nonahydrate.<\/p>\nContent<\/strong><\/p>\n15.0 per cent to 16.5 per cent of Mg (dried substance).<\/p>\n

Appearance<\/h3>\nWhite or almost white, fine powder.<\/p>\n

Solubility<\/h3>\nSparingly soluble in water, practically insoluble in ethanol (96 per cent). It dissolves in dilute hydrochloric<\/p>\nacid.<\/p>\n

IDENTIFICATION<\/h2>\nA. It gives the reaction of citrates (2.3.1).<\/p>\nB. It gives the reaction of magnesium (2.3.1).<\/p>\nC. Loss on drying (see Tests).<\/p>\n

TESTS<\/h2>\n

Solution S<\/h3>\nDissolve 2.5 g in 15 mL of dilute hydrochloric acid R with heating. Cool and dilute to 100 mL with distilled<\/p>\nwater R.<\/p>\n

Appearance of solution<\/h3>\nSolution S is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).<\/p>\n

pH (2.2.3)<\/h3>\n6.0 to 8.5.<\/p>\nDisperse 5.0 g in carbon dioxide-free water R and dilute to 100 mL with the same solvent. Centrifuge and measure the pH of the clear supernatant.<\/p>\n

Sulfates (2.4.13)<\/h3>\nMaximum 0.2 per cent.<\/p>\nDilute 3.0 mL of solution S to 15 mL with distilled water R.<\/p>\n

Calcium (2.4.3)<\/h3>\nMaximum 0.2 per cent.<\/p>\nTo a mixture of 2 mL of solution S and 8 mL of distilled water R, add about 0.2 mL of ammonia R and dilute to 15 mL with distilled water R.<\/p>\n

Iron (2.4.9)<\/h3>\nMaximum 100 ppm.<\/p>\nDilute 4.0 mL of solution S to 10 mL with distilled water R.<\/p>\n

Loss on drying (2.2.32)<\/h3>\n24.0 to 28.0 per cent, determined on 1.000 g by drying in an oven at 180 \u00b1 10 \u00b0C for 5 h.<\/p>\n

DEFINITION<\/h2>\n
Trimagnesium bis(2-hydroxypropane-1,2,3-tricarboxylate) nonahydrate.<\/p>\n
Content<\/strong><\/p>\n
15.0 per cent to 16.5 per cent of Mg (dried substance).<\/p>\n

Appearance<\/h3>\n
White or almost white, fine powder.<\/p>\n

Solubility<\/h3>\n
Sparingly soluble in water, practically insoluble in ethanol (96 per cent). It dissolves in dilute hydrochloric<\/p>\n
acid.<\/p>\n

IDENTIFICATION<\/h2>\n
A. It gives the reaction of citrates (2.3.1).<\/p>\n
B. It gives the reaction of magnesium (2.3.1).<\/p>\n
C. Loss on drying (see Tests).<\/p>\n

Solution S<\/h3>\n
Dissolve 2.5 g in 15 mL of dilute hydrochloric acid R with heating. Cool and dilute to 100 mL with distilled<\/p>\n
water R.<\/p>\n

Appearance of solution<\/h3>\n
Solution S is clear (2.2.1) and not more intensely coloured than reference solution BY6 (2.2.2, Method II).<\/p>\n

pH (2.2.3)<\/h3>\n
6.0 to 8.5.<\/p>\n
Disperse 5.0 g in carbon dioxide-free water R and dilute to 100 mL with the same solvent. Centrifuge and measure the pH of the clear supernatant.<\/p>\n

Sulfates (2.4.13)<\/h3>\n
Maximum 0.2 per cent.<\/p>\n
Dilute 3.0 mL of solution S to 15 mL with distilled water R.<\/p>\n

Calcium (2.4.3)<\/h3>\n
Maximum 0.2 per cent.<\/p>\n
To a mixture of 2 mL of solution S and 8 mL of distilled water R, add about 0.2 mL of ammonia R and dilute to 15 mL with distilled water R.<\/p>\n

Iron (2.4.9)<\/h3>\n
Maximum 100 ppm.<\/p>\n
Dilute 4.0 mL of solution S to 10 mL with distilled water R.<\/p>\n

Loss on drying (2.2.32)<\/h3>\n
24.0 to 28.0 per cent, determined on 1.000 g by drying in an oven at 180 \u00b1 10 \u00b0C for 5 h.<\/p>\n