Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n
(Ph. Eur. monograph 2396)<\/p>\n
Action and use<\/strong><\/p>\n Non-ionic surfactant.<\/p>\n Ph Eur<\/p>\n Mixture of esters of fatty acids, mainly Oleic acid (0799), and sorbitol ethoxylated with approximately 40 moles of ethylene oxide for each mole of sorbitol. 7 moles of oleic acid are used for each mole of sorbitol. It also contains macrogol fatty acid esters.<\/p>\n Appearance:<\/strong> Solubility:<\/strong> Relative density: Viscosity (2.2.9): First identification: A, D. A. Infrared absorption spectrophotometry (2.2.24). B. Hydroxyl value (see Tests). Acid value (2.5.1) Hydroxyl value (2.5.3, Method A) Peroxide value Introduce 10.0 g into a 100 mL beaker and dissolve with 20 mL of glacial acetic acid R. Add 1 mL of saturated potassium iodide solution R, mix and allow to stand for 1 min. Add 50 mL of carbon dioxide-free water R and a magnetic stirring bar. Titrate with 0.01 M sodium thiosulfate, determining the end-point potentiometrically (2.2.20). Carry out a blank titration.<\/p>\n Determine the peroxide value using the following expression:<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n (n\u2081\u2212n\u2082) \u00d7 M \u00d7 1000\/m<\/p>\n n\u2081 = volume of 0.01 M sodium thiosulfate required for the titration of the substance to be examined, in millilitres; Saponification value (2.5.6) Use 30.0 mL of 0.5 M alcoholic potassium hydroxide, heat under reflux for 60 min and add 50 mL of anhydrous ethanol R before carrying out the titration.<\/p>\n Composition of fatty acids (2.4.22, Method C) Composition of the fatty-acid fraction of the substance: Ethylene oxide and dioxan (2.4.25, Method A) Water (2.5.12) Sulfated ash Heat a silica crucible to redness for 30 min, allow to cool in a desiccator and weigh. Evenly distribute 1.0 g of the substance to be examined in the crucible and weigh. Dry at 100-105 \u00b0C for 1 h and ignite in a muffle furnace at 600 \u00b1 25 \u00b0C, until the substance is thoroughly charred. Carry out the test for sulfated ash (2.4.14) on the residue obtained, starting from \u201cMoisten the substance to be examined…\u201d.<\/p>\n In an airtight container, protected from light.<\/p>\n Ph Eur<\/p>\n","protected":false},"excerpt":{"rendered":" Edition: BP 2025 (Ph. Eur. 11.6 update) (Ph. Eur. monograph 2396) Action and use Non-ionic surfactant. Ph Eur DEFINITION Mixture of esters of fatty acids, mainly Oleic acid (0799), and sorbitol ethoxylated with approximately 40 moles of ethylene oxide for each mole of sorbitol. 7 moles of oleic acid are used for each mole of…<\/p>\n","protected":false},"author":5,"featured_media":22712,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-22711","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=22711"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22711\/revisions"}],"predecessor-version":[{"id":22760,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22711\/revisions\/22760"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/22712"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=22711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=22711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=22711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}DEFINITION<\/h2>\n
CHARACTERS<\/h2>\n
\nClear or slightly opalescent, yellowish, viscous, hygroscopic liquid.<\/p>\n
\nDispersible in water, soluble in isopropyl myristate, in isopropyl palmitate, in mineral oils and in vegetable fatty oils.<\/p>\n
\nAbout 1.0.<\/p>\n
\nabout 175 mPa\u00b7s at 25 \u00b0C.<\/p>\nIDENTIFICATION<\/h2>\n
\nSecond identification: B, C, D.<\/p>\n
\nComparison macrogol 40 sorbitol heptaoleate CRS.<\/p>\n
\nC. Saponification value (see Tests).
\nD. Composition of fatty acids (see Tests).<\/p>\nTESTS<\/h2>\n
\nMaximum 12.0, determined on 3.0 g.<\/p>\n
\n22 to 55.<\/p>\n
\nMaximum 10.0.<\/p>\n
\nn\u2082 = volume of 0.01 M sodium thiosulfate required for the blank titration, in millilitres;
\nM = molarity of the sodium thiosulfate solution;
\nm = mass of the substance to be examined, in grams.<\/p>\n
\n90 to 110, determined on 4.0 g.<\/p>\n
\nUse the mixture of calibrating substances in Table 2.4.22.-3.<\/p>\n
\n\u2014 myristic acid: maximum 5.0 per cent;
\n\u2014 palmitic acid: maximum 16.0 per cent;
\n\u2014 palmitoleic acid: maximum 8.0 per cent;
\n\u2014 stearic acid: maximum 6.0 per cent;
\n\u2014 oleic acid: minimum 58.0 per cent;
\n\u2014 linoleic acid: maximum 18.0 per cent;
\n\u2014 linolenic acid: maximum 4.0 per cent.<\/p>\n
\nMaximum 1 ppm of ethylene oxide and maximum 10 ppm of dioxan.<\/p>\n
\nMaximum 0.5 per cent, determined on 0.50 g.<\/p>\n
\nMaximum 0.25 per cent.<\/p>\nSTORAGE<\/h2>\n