{"id":22691,"date":"2025-10-30T16:18:35","date_gmt":"2025-10-30T09:18:35","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=22691"},"modified":"2025-10-30T16:18:35","modified_gmt":"2025-10-30T09:18:35","slug":"macrogol-30-dipolyhydroxystearate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/macrogol-30-dipolyhydroxystearate\/","title":{"rendered":"Macrogol 30 Dipolyhydroxystearate"},"content":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update)<\/p>\n<p>(Ph. Eur. monograph 2584)<\/p>\n<p>Ph Eur<\/p>\n<h2>DEFINITION<\/h2>\n<p>Mixture of mainly diesters of polymerised 12-hydroxystearic ((12\u039e)-hydroxyoctadecanoic) acid and<br \/>\nMacrogols (1444) obtained by esterification of macrogol with 12-hydroxystearic acid. The average number<br \/>\nof moles of ethylene oxide reacted per mole of substance is 30.<\/p>\n<h2>CHARACTERS<\/h2>\n<p><strong>Appearance<\/strong><\/p>\n<p>Brownish-red, waxy mass.<\/p>\n<p><strong>Solubility<\/strong><\/p>\n<p>Practically insoluble in water, very soluble in methylene chloride and soluble in most aliphatic and aromatic<br \/>\nhydrocarbons.<\/p>\n<p><strong>mp<\/strong><\/p>\n<p>30 \u00b0C to 40 \u00b0C.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A.\u2003Infrared absorption spectrophotometry (2.2.24).<\/p>\n<p>Comparison macrogol 30 dipolyhydroxystearate CRS.<\/p>\n<p>B.\u2003Hydroxyl value (see Tests).<br \/>\nC.\u2003Saponification value (see Tests).<\/p>\n<p>Macrogol 30 Dipolyhydroxystearate<\/p>\n<h2>TESTS<\/h2>\n<p>Acid value (2.5.1)<\/p>\n<p>Maximum 10.0.<\/p>\n<p>Hydroxyl value (2.5.3, Method A)<\/p>\n<p>12 to 30.<\/p>\n<p>Iodine value (2.5.4, Method A)<\/p>\n<p>Maximum 10.0.<\/p>\n<p>Peroxide value (2.5.5)<\/p>\n<p>Maximum 5.0.<\/p>\n<p>Saponification value (2.5.6)<\/p>\n<p>125 to 145, determined on 2.0 g.<\/p>\n<p>Use 30.0 mL of 0.5 M alcoholic potassium hydroxide, heat under reflux for 60 min and add 50 mL of<br \/>\nanhydrous ethanol R before carrying out the titration.<\/p>\n<p>Water (2.5.12)<\/p>\n<p>Maximum 1.0 per cent, determined on 0.50 g.<\/p>\n<p>Sulfated ash (2.4.14)<\/p>\n<p>Maximum 0.5 per cent.<\/p>\n<p>Heat a silica crucible to redness for 30 min, allow to cool in a desiccator and weigh. Evenly distribute 1.0 g in<br \/>\nthe crucible and weigh. Dry at 100-105 \u00b0C for 1 h and ignite in a muffle furnace at 600 \u00b1 25 \u00b0C, until the<br \/>\nsubstance is thoroughly charred. Carry out the test for sulfated ash (2.4.14) on the residue obtained, starting<br \/>\nfrom \u201cMoisten the substance to be examined&#8230;\u201d.<\/p>\n<h2>STORAGE<\/h2>\n<p>In an airtight container.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Edition: BP 2025 (Ph. Eur. 11.6 update) (Ph. Eur. monograph 2584) Ph Eur DEFINITION Mixture of mainly diesters of polymerised 12-hydroxystearic ((12\u039e)-hydroxyoctadecanoic) acid and Macrogols (1444) obtained by esterification of macrogol with 12-hydroxystearic acid. The average number of moles of ethylene oxide reacted per mole of substance is 30. CHARACTERS Appearance Brownish-red, waxy mass. Solubility&#8230;<\/p>\n","protected":false},"author":5,"featured_media":22692,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-22691","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22691","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=22691"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22691\/revisions"}],"predecessor-version":[{"id":22710,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22691\/revisions\/22710"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/22692"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=22691"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=22691"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=22691"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}