(Ph. Eur. monograph 2407)<\/p>\n
Ar\u00a0 \u00a039.95\u00a0 \u00a07440-37-1<\/p>\n
Gas obtained by fractional distillation of ambient air.<\/p>\n
Minimum 99.995 per cent V\/V of Ar, calculated by deduction of the sum of impurities found when performing the test for impurities and the water content.<\/p>\n
This monograph applies to argon for medicinal use.<\/p>\n
Colourless gas.<\/p>\n
At 20 \u00b0C and at a pressure of 101 kPa, 1 volume dissolves in about 29 volumes of water.<\/p>\n
A. Verify that the gas is not oxygen using a paramagnetic analyser (2.5.27).<\/p>\n
B. Gas chromatography (2.2.28).<\/p>\n
Gas to be examined: The substance to be examined.<\/p>\n
Reference gas (a): Ambient air.<\/p>\n
Reference gas (b): Argon R1.<\/p>\n
Column:<\/p>\n
\u2014 material: stainless steel;<\/p>\n
\u2014 size: l = 2 m, \u00d8 = 2 mm;<\/p>\n
\u2014 stationary phase: molecular sieve for chromatography R (0.5 nm).<\/p>\n
Carrier gas: helium for chromatography R.<\/p>\n
Flow rate 40 mL\/min.<\/p>\n
Temperature:<\/p>\n
\u2014 column: 50 \u00b0C;<\/p>\n
\u2014 detector: at a constant temperature between 50 \u00b0C and 200 \u00b0C.<\/p>\n
Detection: Thermal conductivity.<\/p>\n
Injection: 1 mL loop injector.<\/p>\n
System suitability Reference gas (a):<\/p>\n
\u2014 resolution: minimum 1.5 between the peaks due to argon\/oxygen and nitrogen.<\/p>\n
Results: The principal peak in the chromatogram obtained with the gas to be examined is similar in retention time to the principal peak in the chromatogram obtained with reference gas (b).<\/p>\n
Gas chromatography (2.2.28).<\/p>\n
Gas to be examined: The substance to be examined.<\/p>\n
Reference gas: Use the following mixture of gases in argon R1: methane R1 (5 ppm V\/V), nitrogen R1 (5 ppm V\/V), oxygen R (5 ppm V\/V).<\/p>\n
Column:<\/p>\n
\u2014 material: stainless steel;<\/p>\n
\u2014 size: l = 4 m, \u00d8 = 4 mm;<\/p>\n
\u2014 stationary phase: molecular sieve for chromatography R (0.5 nm).<\/p>\n
Carrier gas argon R1.<\/p>\n
Flow rate 70 mL\/min.<\/p>\n
Temperature:<\/p>\n
\u2014 column: 80 \u00b0C;<\/p>\n
\u2014 detector: 40 \u00b0C.<\/p>\n
Detection: Discharge ionisation.<\/p>\n
Injection: 1 mL.<\/p>\n
Sample rate: 100 mL\/min.<\/p>\n
Relative retention: With reference to impurity C (retention time = about 4.7 min): impurity A = about 0.4; impurity B = about 0.7.<\/p>\n
System suitability Reference gas:<\/p>\n
\u2014 resolution: minimum 3.0 between the peaks due to impurities A and B and minimum 2.0 between the peaks due to impurities B and C.<\/p>\n
Limits:<\/p>\n
\u2014 impurity A: not more than the area of the corresponding peak in the chromatogram obtained with the reference gas (5.0 ppm V\/V);<\/p>\n
\u2014 total: maximum 0.0040 per cent of the sum of the areas of all the peaks (40.0 ppm V\/V).<\/p>\n
Maximum 10.0 ppm V\/V, determined using an electrolytic hygrometer.<\/p>\n
In gaseous or liquid state, in suitable containers, complying with the legal regulations.<\/p>\n
Specified impurities A, D.<\/p>\n
Other detectable impurities B, C.<\/p>\n
A. O2<\/sub>: oxygen, (Ph. Eur. monograph 2407) Ar\u00a0 \u00a039.95\u00a0 \u00a07440-37-1 DEFINITION Gas obtained by fractional distillation of ambient air. Content Minimum 99.995 per cent V\/V of Ar, calculated by deduction of the sum of impurities found when performing the test for impurities and the water content. This monograph applies to argon for medicinal use. CHARACTERS Appearance Colourless gas….<\/p>\n","protected":false},"author":3,"featured_media":2251,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[174],"tags":[],"class_list":["post-2242","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicinal-substances"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/2242","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=2242"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/2242\/revisions"}],"predecessor-version":[{"id":5492,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/2242\/revisions\/5492"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/2251"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=2242"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=2242"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=2242"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nB. N2<\/sub>: nitrogen,
\nC. CH4<\/sub>: methane,
\nD. H2<\/sub>O: water.<\/p>\n","protected":false},"excerpt":{"rendered":"