{"id":22391,"date":"2025-10-30T09:03:16","date_gmt":"2025-10-30T02:03:16","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=22391"},"modified":"2025-10-30T09:03:16","modified_gmt":"2025-10-30T02:03:16","slug":"acepromazine-maleate","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/acepromazine-maleate\/","title":{"rendered":"Acepromazine Maleate"},"content":{"rendered":"<p>C<sub>19<\/sub>H<sub>22<\/sub>N<sub>2<\/sub>OS,C<sub>4<\/sub>H<sub>4<\/sub>O<sub>4<\/sub>\u00a0 \u00a0 \u00a0 \u00a0442.5\u00a0 \u00a0 \u00a0 \u00a03598-37-6<\/p>\n<p><strong>Action and use<\/strong><\/p>\n<p>Dopamine receptor antagonist; neuroleptic.<\/p>\n<p><strong>Preparations<\/strong><\/p>\n<p>Acepromazine Injection<\/p>\n<p>Acepromazine Tablets<\/p>\n<h2>DEFINITION<\/h2>\n<p>Acepromazine Maleate is 2-acetyl-10-(3-dimethylaminopropyl) phenothiazine hydrogen maleate.<\/p>\n<p>It contains not less than 98.5% and not more than 101.0% of C<sub>19<\/sub>H<sub>22<\/sub>N<sub>2<\/sub>OS,C<sub>4<\/sub>H<sub>4<\/sub>O<sub>4<\/sub>\u00a0, calculated with reference to the dried substance.<\/p>\n<h2>CHARACTERISTICS<\/h2>\n<p>A yellow, crystalline powder.<\/p>\n<p>Soluble in water; freely soluble in chloroform; soluble in ethanol (96%); slightly soluble in ether.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. Dissolve 20 mg in 2 mL of water, add 3 mL of 2M sodium hydroxide, extract with 5 mL of cyclohexane and evaporate to dryness under reduced pressure. The infrared absorption<br \/>\nspectrum of the residue, Appendix II A, is concordant with the reference spectrum of acepromazine (RSV 01).<\/p>\n<p>B. Complies with the test for identification of phenothiazines, Appendix III A, applying to the plate 1 \u03bcL of each solution and using acepromazine maleate BPCRS for the preparation of solution (2).<\/p>\n<p>C. Dissolve 0.2 g in a mixture of 3 mL of water and 2 mL of 5M sodium hydroxide and shake with three 3-mL quantities of ether. Add to the aqueous solution 2 mL of bromine solution, warm in a water bath for 10 minutes, heat to boiling, cool and add 0.25 mL to a solution of 10 mg of resorcinol in 3 mL of sulfuric acid. A bluish black colour develops on heating for 15 minutes in a water bath.<\/p>\n<h2>TESTS<\/h2>\n<h3>Acidity<\/h3>\n<p>pH of a 1.0% w\/v solution, 4.0 to 4.5, Appendix V L.<\/p>\n<h3>Melting point<\/h3>\n<p>136\u00b0 to 139\u00b0, Appendix V A.<\/p>\n<h3>Related substances<\/h3>\n<p>Complies with the test for related substances in phenothiazines, Appendix III A, but using a mixture of 75 volumes of n-hexane, 17 volumes of butan-2-one and 8 volumes of diethylamine as the mobile phase.<\/p>\n<h4>Loss on drying<\/h4>\n<p>When dried to constant weight at 105\u00b0, loses not more than 1.0% of its weight. Use 1 g.<\/p>\n<h4>Sulfated ash<\/h4>\n<p>Not more than 0.2%, Appendix IX A.<\/p>\n<h2>ASSAY<\/h2>\n<p>Dissolve 0.4 g in 50 mL of acetic anhydride and carry out Method I for non-aqueous titration, Appendix VIII A, using crystal violet solution as indicator. Each mL of 0.1M perchloric acid VS is equivalent to 44.25 mg of C<sub>19<\/sub>H<sub>22<\/sub>N<sub>2<\/sub>OS,C<sub>4<\/sub>H<sub>4<\/sub>O<sub>4<\/sub><\/p>\n","protected":false},"excerpt":{"rendered":"<p>C19H22N2OS,C4H4O4\u00a0 \u00a0 \u00a0 \u00a0442.5\u00a0 \u00a0 \u00a0 \u00a03598-37-6 Action and use Dopamine receptor antagonist; neuroleptic. Preparations Acepromazine Injection Acepromazine Tablets DEFINITION Acepromazine Maleate is 2-acetyl-10-(3-dimethylaminopropyl) phenothiazine hydrogen maleate. It contains not less than 98.5% and not more than 101.0% of C19H22N2OS,C4H4O4\u00a0, calculated with reference to the dried substance. CHARACTERISTICS A yellow, crystalline powder. Soluble in water;&#8230;<\/p>\n","protected":false},"author":2,"featured_media":22393,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[176],"tags":[],"class_list":["post-22391","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-british-pharmacopoeia-veterinary-2020"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22391","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=22391"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22391\/revisions"}],"predecessor-version":[{"id":22395,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22391\/revisions\/22395"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/22393"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=22391"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=22391"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=22391"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}