{"id":22386,"date":"2025-10-30T08:54:53","date_gmt":"2025-10-30T01:54:53","guid":{"rendered":"https:\/\/nhathuocngocanh.com\/bp\/?p=22386"},"modified":"2025-10-30T08:54:53","modified_gmt":"2025-10-30T01:54:53","slug":"acepromazine-injection","status":"publish","type":"post","link":"https:\/\/nhathuocngocanh.com\/bp\/acepromazine-injection\/","title":{"rendered":"Acepromazine Injection"},"content":{"rendered":"<p><strong>Action and use<\/strong><\/p>\n<p>Dopamine receptor antagonist; neuroleptic.<\/p>\n<h2>DEFINITION<\/h2>\n<p>Acepromazine Injection is a sterile solution of Acepromazine Maleate in Water for Injections. The pH of the solution is adjusted to about 5 by the addition of Sodium Hydroxide.<\/p>\n<p>The injection complies with the requirements stated under Parenteral Preparations and with the following requirements.<\/p>\n<h3>Content of acepromazine, C<sub>19<\/sub>H<sub>22<\/sub>N<sub>2<\/sub>OS<\/h3>\n<p>92.5 to 107.5% of the stated amount.<\/p>\n<h2>IDENTIFICATION<\/h2>\n<p>A. To a volume containing the equivalent of 20 mg of acepromazine add 2 mL of water and 3 mL of 2M sodium hydroxide, extract with two 5 mL quantities of cyclohexane and evaporate to dryness under reduced pressure. The infrared absorption spectrum of the residue, Appendix II A, is concordant with the reference spectrum of acepromazine (RSV 01).<\/p>\n<p>B. Complies with the test for identification of phenothiazines, Appendix III A, applying to the plate 1 \u03bcL of each of the following solutions. For solution (1) extract a volume containing the equivalent of 20 mg of acepromazine with two 5 mL quantities of chloroform and use the combined extracts. Solution (2) is a solution of acepromazine maleate BPCRS in chloroform containing the equivalent of 0.2% w\/v of acepromazine.<\/p>\n<p>C. To 5 mg of the residue obtained in test A add 2 mL of sulfuric acid. A yellow colour is produced which becomes deep orange on warming for 2 minutes.<\/p>\n<p>D. To a volume of the injection containing the equivalent of 25 mg of acepromazine add 2 mL of 5M sodium hydroxide and shake with three 3 mL quantities of ether. Add 2 mL of bromine solution to the aqueous solution, warm in a water bath for 10 minutes, heat to boiling and cool. Add\u00a0 0.25 mL to a solution of 10 mg of resorcinol in 3 mL of sulfuric acid and heat for 15 minutes in a water bath. A bluish black colour develops.<\/p>\n<h2>TESTS<\/h2>\n<h3>Acidity<\/h3>\n<p>pH, 4.5 to 5.5, Appendix V L.<\/p>\n<h2>ASSAY<\/h2>\n<p>To a volume containing the equivalent of 40 mg of acepromazine add 5 mL of 1M sodium hydroxide and extract with 50 mL quantities of chloroform until the chloroform extract is colourless. Wash the extracts with the same 10 mL of water and filter through a plug of absorbent cotton previously moistened with chloroform. Evaporate the combined extracts to dryness and dissolve the residue in 15 mL of acetic anhydride. Carry out Method I for non-aqueous titration,<br \/>\nAppendix VIII A, using 0.02M perchloric acid VS as titrant and crystal violet solution as indicator. Each mL of 0.02M perchloric acid VS is equivalent to 6.529 mg of C<sub>19<\/sub>H<sub>22<\/sub>N<sub>2<\/sub>OS.<\/p>\n<h2>STORAGE<\/h2>\n<p>Acepromazine Injection should be protected from light.<\/p>\n<h2>LABELLING<\/h2>\n<p>The strength is stated as the equivalent amount of acepromazine in a suitable dose-volume.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Action and use Dopamine receptor antagonist; neuroleptic. DEFINITION Acepromazine Injection is a sterile solution of Acepromazine Maleate in Water for Injections. The pH of the solution is adjusted to about 5 by the addition of Sodium Hydroxide. The injection complies with the requirements stated under Parenteral Preparations and with the following requirements. Content of acepromazine,&#8230;<\/p>\n","protected":false},"author":2,"featured_media":22388,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[176],"tags":[],"class_list":["post-22386","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-british-pharmacopoeia-veterinary-2020"],"acf":[],"_links":{"self":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22386","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/comments?post=22386"}],"version-history":[{"count":2,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22386\/revisions"}],"predecessor-version":[{"id":22390,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/posts\/22386\/revisions\/22390"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media\/22388"}],"wp:attachment":[{"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/media?parent=22386"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/categories?post=22386"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nhathuocngocanh.com\/bp\/wp-json\/wp\/v2\/tags?post=22386"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}